Role of Prophylactic Antibiotics in Laparoscopic Cholecystectomy and Risk Factors for Surgical Site Infection: A Randomized Controlled Trial

2010 ◽  
Vol 11 (4) ◽  
pp. 367-370 ◽  
Author(s):  
Navneet Sharma ◽  
Pankaj Kumar Garg ◽  
Niladhar S. Hadke ◽  
Deepti Choudhary
Keyword(s):  
Risk Factors ◽  
Randomized Controlled Trial ◽  
Laparoscopic Cholecystectomy ◽  
Surgical Site Infection ◽  
Controlled Trial ◽  
Prophylactic Antibiotics ◽  
Site Infection ◽  
Randomized Controlled

scholarly journals Randomized controlled trial comparing cefazolin with ceftriaxone in perioperative prophylaxis in orthopaedic surgeries

2018 ◽  
Vol 1 (1) ◽  
pp. 36-43
Author(s):  
Rosan Prasad Shah Kalawar ◽  
BP Shrestha ◽  
GP Khanal ◽  
P Chaudhary ◽  
R Rijal ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Surgical Site Infection ◽  
Controlled Trial ◽  
Health Sciences ◽  
Prophylactic Antibiotics ◽  
The Other ◽  
Site Infection ◽  
Perioperative Prophylaxis ◽  
Randomized Controlled ◽  
Significant Difference

Background: Surgical site infection is one of the most dreaded complications faced by an orthopaedic surgeon. In spite of cefazolin being recommended as perioperative antibiotic, many orthopaedic surgeons continue to use ceftriaxone as perioperative antibiotic.Objective: To compare the effectiveness of cefazolin and ceftriaxone as perioperative prophylactic antibiotics in the prevention of surgical site infection in clean elective orthopaedic surgeries.Methods: We conducted a randomized controlled trial in 197 patients undergoing clean elective orthopaedic surgeries. The patients were divided into two groups. One group received intravenous prophylactic antibiotics cefazolin and gentamicin and the other group received ceftriaxone and gentamicin in standard doses for 48 hours. Both groups were followed by oral Cephadroxyl for 7 days. The patients were followed up for three months.Results: There was no significant difference in the rate of surgical site infection among the two groups.Conclusion: We conclude that there is no difference in the effectiveness of prevention of surgical site infection between cefazolin and ceftriaxone.Journal of BP Koirala Institute of Health Sciences, Vol. 1, No. 1, 2018, page: 36-43

Circular pOlyethylene drape in preVEntion of suRgical site infection (COVER Trial): Study protocol of a randomized controlled trial

2018 ◽  
Author(s):  
Ri Na Yoo ◽  
Hyung Jin Kim ◽  
Jae Im Lee ◽  
Won-Kyung Kang ◽  
Bong-Hyeon Kye ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Abdominal Surgery ◽  
Surgical Site Infection ◽  
Controlled Trial ◽  
Dropout Rate ◽  
Site Infection ◽  
Gi Tract ◽  
Randomized Controlled ◽  
Wound Protector ◽  
Open Abdominal Surgery

Abstract Background: Surgical site infection (SSI) after abdominal surgery is still a significant morbidity associated with an increased socioeconomic burden and poor quality of life. SSI prevalence rates as high as 40% in cases of fecal contamination have been reported; however, current methods to reduce SSI are limited to elective abdominal surgery. Further evaluation of preventive measures for reducing SSI is necessary. Methods/design: The COVER trial investigates whether the application of a dual-ring circular plastic wound protector reduces the rate of SSI in patients undergoing open abdominal surgery related to the gastrointestinal (GI) tract, regardless of the type of wound classified by the Center for Disease Control (CDC). The COVER trial is a multicenter, randomized controlled clinical trial with two parallel arms – one using a wound protector and the other using conventional surgical dressing gauze. The primary outcome will measure the rate of SSI in two groups. Statistical analysis of the primary end point will be based on the intention-to-treat population. The sample size is determined to achieve a study power of 80% at 95% 2-sided confidence limits. Considering a dropout rate of up to 5%, a total of 458 patients, 229 patients in each group, will be enrolled in this study. Discussion: The COVER trial will provide high-quality evidence for using a circular polyethylene drape in open abdominal surgery for the GI tract in all types of wound. The design of the trial will deliver high external validity and clinical significance. Trial registration: The trial protocol was registered at ClinicalTrials.gov (NCT 03170843) on May 31, 2017. https://clinicaltrials.gov/ct2/show/NCT03170843?term=NCT+03170843&rank=1 Keywords: Circular polyethylene drape, Abdominal surgery, Gastrointestinal tract, Surgical site infection, Randomized controlled trial

scholarly journals Perioperative Prophylactic Antibiotics in Orthopaedic Surgery

2013 ◽  
Vol 3 (1) ◽  
pp. 5-10
Author(s):  
Bikram Prasad Shrestha ◽  
Surya Raj Niraula ◽  
Parvin Nepal ◽  
Guru Prasad Khanal ◽  
Navin Karn ◽  
...  
Keyword(s):  
Surgical Site Infection ◽  
Orthopaedic Surgery ◽  
Controlled Trial ◽  
Prophylactic Antibiotics ◽  
Drug Resistant ◽  
Site Infection ◽  
Oral Antibiotics ◽  
Randomized Controlled ◽  
Orthopaedic Patients ◽  
Significant Difference

Introduction: In our country, various institutes have different protocols for postoperative antibiotics. Many western literature have mentioned that administration of prophylactic antibiotics for longer than 24 hours has no advantage and may actually lead to superinfection with drug-resistant organisms. Because of environmental and theater condition most of the surgeon here are very reluctant to use prophylactic antibiotics for only 24 hours. The objective of the study was to find out the effect of duration of prophylactic antibiotics on the rate of surgical site infection in clean elective orthopaedic surgeries. Methods: This was a randomized controlled trial involving 207 clean elective orthopaedic patients undergoing surgery. The patients were divided into three groups which received intravenous prophylactic antibiotics for 24 hours, 48 hours and 48 hours followed by 7 days of oral antibiotics respectively. The patients were followed up for three months postoperatively. Result: There was no significant difference in the rate of surgical site infection among the three groups. Conclusion: We conclude that there is no benefit in prolonging prophylactic antibiotics beyond 24 hours. DOI: http://dx.doi.org/10.3126/noaj.v3i1.9318   Nepal Orthopedic Association Journal 2013 Vol.3(1): 5-10

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