scholarly journals Intravenous Human Umbilical Cord-Derived Mesenchymal Stromal Cell Administration in Models of Moderate and Severe Intracerebral Hemorrhage

2020 ◽  
Vol 29 (9) ◽  
pp. 586-598 ◽  
Author(s):  
Tanira Giara Mello ◽  
Paulo Henrique Rosado-de-Castro ◽  
Raquel Maria Pereira Campos ◽  
Juliana Ferreira Vasques ◽  
William Simões Rangel-Junior ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Umbilical Cord ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Human Umbilical Cord

Growth and Differentiation Properties of Mesenchymal Stromal Cell Populations Derived from Whole Human Umbilical Cord

2010 ◽  
Vol 7 (1) ◽  
pp. 17-31 ◽  
Author(s):  
Ingrida Majore ◽  
Pierre Moretti ◽  
Frank Stahl ◽  
Ralf Hass ◽  
Cornelia Kasper
Keyword(s):  
Umbilical Cord ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Cell Populations ◽  
Human Umbilical Cord

scholarly journals Human Umbilical Cord Mesenchymal Stromal Cells Attenuate Systemic Sepsis in Part by Enhancing Peritoneal Macrophage Bacterial Killing via Heme Oxygenase-1 Induction in Rats

2020 ◽  
Vol 132 (1) ◽  
pp. 140-154 ◽  
Author(s):  
Mirjana Jerkic ◽  
Stéphane Gagnon ◽  
Razieh Rabani ◽  
Taylor Ward-Able ◽  
Claire Masterson ◽  
...  
Keyword(s):  
Umbilical Cord ◽  
Heme Oxygenase ◽  
Mesenchymal Stromal Cells ◽  
Dose Response ◽  
Stromal Cells ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Heme Oxygenase 1 ◽  
Human Umbilical Cord ◽  
Bacterial Killing

Abstract Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New Background Mesenchymal stromal cells have therapeutic potential in sepsis, but the mechanism of action is unclear. We tested the effects, dose-response, and mechanisms of action of cryopreserved, xenogeneic-free human umbilical cord mesenchymal stromal cells in a rat model of fecal peritonitis, and examined the role of heme oxygenase-1 in protection. Methods Separate in vivo experiments evaluated mesenchymal stromal cells in fecal sepsis, established dose response (2, 5, and 10 million cells/kg), and the role of heme oxygenase-1 in mediating human umbilical cord–derived mesenchymal stromal/stem cell effects. Ex vivo studies utilized pharmacologic blockers and small inhibitory RNAs to evaluate mechanisms of mesenchymal stromal cell enhanced function in (rodent, healthy and septic human) macrophages. Results Human umbilical cord mesenchymal stromal cells reduced injury and increased survival (from 48%, 12 of 25 to 88%, 14 of 16, P = 0.0033) in fecal sepsis, with dose response studies demonstrating that 10 million cells/kg was the most effective dose. Mesenchymal stromal cells reduced bacterial load and peritoneal leukocyte infiltration (from 9.9 ± 3.1 × 106/ml to 6.2 ± 1.8 × 106/ml, N = 8 to 10 per group, P < 0.0001), and increased heme oxygenase-1 expression in peritoneal macrophages, liver, and spleen. Heme oxygenase-1 blockade abolished the effects of mesenchymal stromal cells (N = 7 or 8 per group). Mesenchymal stromal cells also increased heme oxygenase-1 expression in macrophages from healthy donors and septic patients. Direct ex vivo upregulation of macrophage heme oxygenase-1 enhanced macrophage function (phagocytosis, reactive oxygen species production, bacterial killing). Blockade of lipoxin A4 production in mesenchymal stromal cells, and of prostaglandin E2 synthesis in mesenchymal stromal cell/macrophage cocultures, prevented upregulation of heme oxygenase-1 in macrophages (from 9.6 ± 5.5-fold to 2.3 ± 1.3 and 2.4 ± 2.3 respectively, P = 0.004). Knockdown of heme oxygenase-1 production in macrophages ablated mesenchymal stromal cell enhancement of macrophage phagocytosis. Conclusions Human umbilical cord mesenchymal stromal cells attenuate systemic sepsis by enhancing peritoneal macrophage bacterial killing, mediated partly via upregulation of peritoneal macrophage heme oxygenase-1. Lipoxin A4 and prostaglandin E2 play key roles in the mesenchymal stromal cell and macrophage interaction.

scholarly journals Characterizing the SLC39A14 zinc transporter and collagen products of the chondrocytes from the human umbilical cord-derived mesenchymal stromal cell

2019 ◽  
Vol 8 (2) ◽  
pp. 672
Author(s):  
Ketut Dewi Kumara Wati ◽  
Endah Dianty Pratiwix ◽  
Yanni Dirgantara ◽  
Cynthia Retna Sartika ◽  
Meita Dhamayanti ◽  
...  
Keyword(s):  
Umbilical Cord ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Zinc Transporter ◽  
Human Umbilical Cord

scholarly journals Biodistribution of gadolinium- and near infrared-labeled human umbilical cord mesenchymal stromal cell-derived exosomes in tumor bearing mice

Theranostics ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. 2325-2345 ◽  
Author(s):  
Javier Abello ◽  
Tuyen Duong Thanh Nguyen ◽  
Ramesh Marasini ◽  
Santosh Aryal ◽  
Mark Louis Weiss
Keyword(s):  
Umbilical Cord ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Near Infrared ◽  
Human Umbilical Cord ◽  
Tumor Bearing

Serum- and xeno-free cryopreservation of human umbilical cord tissue as mesenchymal stromal cell source

Cytotherapy ◽  
2015 ◽  
Vol 17 (5) ◽  
pp. 593-600 ◽  
Author(s):  
Takahisa Shimazu ◽  
Yuka Mori ◽  
Atsuko Takahashi ◽  
Hajime Tsunoda ◽  
Arinobu Tojo ◽  
...  
Keyword(s):  
Umbilical Cord ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Human Umbilical Cord ◽  
Cell Source ◽  
Umbilical Cord Tissue

Effect of Storage Conditions on the Integrity of Human Umbilical Cord Mesenchymal Stromal Cell-Derived Microvesicles

2019 ◽  
Vol 167 (1) ◽  
pp. 131-135 ◽  
Author(s):  
Yu. A. Romanov ◽  
N. E. Volgina ◽  
T. N. Dugina ◽  
N. V. Kabaeva ◽  
G. T. Sukhikh
Keyword(s):  
Umbilical Cord ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Storage Conditions ◽  
Human Umbilical Cord
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