scholarly journals Differentiation of Neural Crest Stem Cells in Response to Matrix Stiffness and TGF-β1 in Vascular Regeneration

2020 ◽  
Vol 29 (4) ◽  
pp. 249-256 ◽  
Author(s):  
Xian Li ◽  
Rong Xu ◽  
Xiaolin Tu ◽  
Randall Raphael R. Janairo ◽  
George Kwong ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Crest ◽  
Matrix Stiffness ◽  
Neural Crest Stem Cells ◽  
Vascular Regeneration ◽  
Tgf Β1

scholarly journals Calcineurin initiates smooth muscle differentiation in neural crest stem cells

2004 ◽  
Vol 165 (4) ◽  
pp. 483-491 ◽  
Author(s):  
Kris M. Mann ◽  
Jenna Lynn Ray ◽  
Edward S. Moon ◽  
Kristin M. Sass ◽  
Mark R. Benson
Keyword(s):  
Stem Cells ◽  
Smooth Muscle ◽  
Neural Crest ◽  
Gene Disruption ◽  
Transforming Growth Factor ◽  
Gene Products ◽  
Loss Of Function ◽  
Neural Crest Stem Cells ◽  
Tgf Β1 ◽  
Calcineurin Signaling

The process of vascular smooth muscle cell (vSMC) differentiation is critical to embryonic angiogenesis. However, despite its importance, the vSMC differentiation program remains largely undefined. Murine gene disruption studies have identified several gene products that are necessary for vSMC differentiation, but these methodologies cannot establish whether or not a factor is sufficient to initiate the differentiation program. A gain-of-function system consisting of normal vSMC progenitor cells would serve as a useful complement to whole animal loss-of-function studies. We use such a system here, namely freshly isolated rat neural crest stem cells (NCSCs), to show that activation of the calcineurin signaling pathway is sufficient to drive these cells toward a smooth muscle fate. In addition, we present data suggesting that transforming growth factor (TGF)-β1, which also causes NCSCs to differentiate into smooth muscle, activates calcineurin signaling in NCSCs, leading to a model in which activation of calcineurin signaling is the mechanism by which TGF-β1 causes SMC differentiation in these cells.

scholarly journals Matrix stiffness modulates the differentiation of neural crest stem cells in vivo

2018 ◽  
Vol 234 (5) ◽  
pp. 7569-7578 ◽  
Author(s):  
Yiqian Zhu ◽  
Xian Li ◽  
Randall Raphael R. Janairo ◽  
George Kwong ◽  
Anchi D. Tsou ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Crest ◽  
Matrix Stiffness ◽  
Neural Crest Stem Cells

scholarly journals Derivation of neural crest stem cells from human epidermal keratinocytes requires FGF-2, IGF-1, and inhibition of TGF-β1

2018 ◽  
Vol 3 (3) ◽  
pp. 256-264 ◽  
Author(s):  
Georgios Tseropoulos ◽  
Samaneh Moghadasi Boroujeni ◽  
Vivek K. Bajpai ◽  
Pedro Lei ◽  
Stelios T. Andreadis
Keyword(s):  
Stem Cells ◽  
Neural Crest ◽  
Epidermal Keratinocytes ◽  
Human Epidermal Keratinocytes ◽  
Neural Crest Stem Cells ◽  
Tgf Β1

scholarly journals Neural Crest Stem Cells Persist in the Adult Gut but Undergo Changes in Self-Renewal, Neuronal Subtype Potential, and Factor Responsiveness

Neuron ◽  
2002 ◽  
Vol 35 (4) ◽  
pp. 657-669 ◽  
Author(s):  
Genevieve M. Kruger ◽  
Jack T. Mosher ◽  
Suzanne Bixby ◽  
Nancy Joseph ◽  
Toshihide Iwashita ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Crest ◽  
Self Renewal ◽  
Neural Crest Stem Cells ◽  
Neuronal Subtype

scholarly journals Human iPSC-derived Neural Crest Stem Cells can produce EPO and induce erythropoiesis in anemic mice

2021 ◽  
pp. 102476
Author(s):  
Valerio Brizi ◽  
Sara Buttò ◽  
Domenico Cerullo ◽  
Angelo Michele Lavecchia ◽  
Raquel Rodrigues-Diez ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Crest ◽  
Neural Crest Stem Cells ◽  
Human Ipsc

scholarly journals Is There a Role for Neural Crest Stem Cells in Periodontal Regeneration?

2015 ◽  
Vol 2 (4) ◽  
pp. 275-281 ◽  
Author(s):  
Atsushi Tomokiyo ◽  
Kim Hynes ◽  
Stan Gronthos ◽  
Naohisa Wada ◽  
P. Mark Bartold
Keyword(s):  
Stem Cells ◽  
Neural Crest ◽  
Periodontal Regeneration ◽  
Neural Crest Stem Cells
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