scholarly journals Rat Cranial Bone-Derived Mesenchymal Stem Cell Transplantation Promotes Functional Recovery in Ischemic Stroke Model Rats

2018 ◽  
Vol 27 (15) ◽  
pp. 1053-1061 ◽  
Author(s):  
Masaru Abiko ◽  
Takafumi Mitsuhara ◽  
Takahito Okazaki ◽  
Takeshi Imura ◽  
Kei Nakagawa ◽  
...  
Keyword(s):  
Stem Cell ◽  
Ischemic Stroke ◽  
Mesenchymal Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Functional Recovery ◽  
Cranial Bone ◽  
Stroke Model ◽  
Mesenchymal Stem Cell Transplantation

scholarly journals Mitochondrial Transfer through Pericardium Contributes to Functional Recovery in Ischemic Cardiomyopathy

2020 ◽  
Author(s):  
Daisuke MORI ◽  
Shigeru MIYAGAWA ◽  
Takuji KAWAMURA ◽  
Daisuke YOSHIOKA ◽  
Hiroki HATA ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Functional Recovery ◽  
Ischemic Cardiomyopathy ◽  
Rat Cardiomyocytes ◽  
Mesenchymal Stem Cell Transplantation ◽  
Mitochondrial Transfer

Abstract Although mesenchymal stem cell transplantation has been efficacious in the treatment of ischemic cardiomyopathy, the underlying mechanisms remain unclear. Herein, we investigated whether mitochondrial transfer could explain the success of cell therapy in ischemic cardiomyopathy. Mitochondrial transfer was examined in co-cultures of human adipose-derived mesenchymal stem cells and rat cardiomyocytes under hypoxic conditions. Functional recovery was monitored in a rat model of myocardial infarction following human adipose-derived mesenchymal stem cell transplantation. In vitro, we observed mitochondrial transfer, which required formation of cell-to-cell contacts and synergistically enhanced energy metabolism. Rat cexhibited mitochondrial transfer three days following human adipose-derived mesenchymal stem cell transplantation to the ischemic heart surface post myocardial infarction. We detected donor mitochondrial DNA in the recipient myocardium concomitant with a significant improvement in cardiac function. In conclusion, mitochondrial transfer is vital for successful cell transplantation therapies and promotes improved treatment outcomes in ischemic cardiomyopathy.

scholarly journals The Effect of CXCR4 Overexpression on Mesenchymal Stem Cell Transplantation in Ischemic Stroke

Cell Medicine ◽  
2012 ◽  
Vol 4 (2) ◽  
pp. 65-76 ◽  
Author(s):  
Oh Young Bang ◽  
Kyung Sil Jin ◽  
Mi Na Hwang ◽  
Ho Young Kang ◽  
Byoung Joon Kim ◽  
...  
Keyword(s):  
Stem Cell ◽  
Ischemic Stroke ◽  
Mesenchymal Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Mesenchymal Stem Cell Transplantation
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