Pig Induced Pluripotent Stem Cell-Derived Neural Rosettes Developmentally Mimic Human Pluripotent Stem Cell Neural Differentiation

2015 ◽  
Vol 24 (16) ◽  
pp. 1901-1911 ◽  
Author(s):  
Amalia Gallegos-Cárdenas ◽  
Robin Webb ◽  
Erin Jordan ◽  
Rachel West ◽  
Franklin D. West ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Differentiation ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Human Pluripotent Stem Cell ◽  
Induced Pluripotent

scholarly journals Modeling Neurological Disorders with Human Pluripotent Stem Cell-Derived Astrocytes

2019 ◽  
Vol 20 (16) ◽  
pp. 3862 ◽  
Author(s):  
Mika Suga ◽  
Takayuki Kondo ◽  
Haruhisa Inoue
Keyword(s):  
Stem Cell ◽  
Neurological Disorders ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Human Diseases ◽  
Human Pluripotent Stem Cell ◽  
Human Astrocytes ◽  
Induced Pluripotent ◽  
Human Ipsc

Astrocytes play vital roles in neurological disorders. The use of human induced pluripotent stem cell (iPSC)-derived astrocytes provides a chance to explore the contributions of astrocytes in human diseases. Here we review human iPSC-based models for neurological disorders associated with human astrocytes and discuss the points of each model.

Zinc Promotes Patient-Derived Induced Pluripotent Stem Cell Neural Differentiation via ERK-STAT Signaling

2020 ◽  
Vol 29 (13) ◽  
pp. 863-875
Author(s):  
Meng Yang ◽  
Dongyu Bao ◽  
Anyuan Shi ◽  
Hao Yuan ◽  
Juan Wang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Differentiation ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Stat Signaling ◽  
Induced Pluripotent

Interleukin-6-Mediated Induced Pluripotent Stem Cell (iPSC)-Derived Neural Differentiation

2017 ◽  
Vol 55 (4) ◽  
pp. 3513-3522 ◽  
Author(s):  
Yanuar Alan Sulistio ◽  
Han Kyu Lee ◽  
Sung Jun Jung ◽  
Klaus Heese
Keyword(s):  
Stem Cell ◽  
Interleukin 6 ◽  
Neural Differentiation ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Induced Pluripotent

scholarly journals A Novel Feeder-Free Culture System for Human Pluripotent Stem Cell Culture and Induced Pluripotent Stem Cell Derivation

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e76205 ◽  
Author(s):  
Sanna Vuoristo ◽  
Sanna Toivonen ◽  
Jere Weltner ◽  
Milla Mikkola ◽  
Jarkko Ustinov ◽  
...  
Keyword(s):  
Cell Culture ◽  
Stem Cell ◽  
Culture System ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Human Pluripotent Stem Cell ◽  
Stem Cell Culture ◽  
Stem Cell Derivation ◽  
Induced Pluripotent

scholarly journals Induced pluripotent stem cell-derived enteric neural crest cells repopulate human aganglionic tissue-engineered intestine to form key components of the enteric nervous system

2020 ◽  
Vol 11 ◽  
pp. 204173142090570 ◽  
Author(s):  
David F Chang ◽  
Samuel M Zuber ◽  
Elizabeth A Gilliam ◽  
Laura-Marie A Nucho ◽  
Gabriel Levin ◽  
...  
Keyword(s):  
Nervous System ◽  
Small Intestine ◽  
Stem Cell ◽  
Enteric Nervous System ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Human Pluripotent Stem Cell ◽  
Cell Therapies ◽  
Induced Pluripotent ◽  
Immunocompromised Mice

Models for enteric neuropathies, in which intestinal nerves are absent or injured, are required to evaluate possible cell therapies. However, existing options, including transgenic mice, are variable and fragile. Here immunocompromised mice were implanted with human pluripotent stem cell–derived tissue-engineered small intestine 10 weeks prior to a second survival surgery in which enteric nervous system precursor cells, or saline controls, were injected into the human intestinal organoid–derived tissue-engineered small intestine and analyzed 4 weeks later. Human intestinal organoid–derived tissue-engineered small intestine implants injected with saline as controls illustrated formation of intestinal epithelium and mesenchyme without an enteric nervous system. Second surgical introduction of human pluripotent stem cell–generated enteric nervous system precursors into developing human intestinal organoid–derived tissue-engineered small intestine implants resulted in proliferative migratory neuronal and glial cells, including multiple neuronal subtypes, and demonstrated function in contractility assays.

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