scholarly journals Hepatocyte Growth Factor Gene-Modified Mesenchymal Stem Cells Augment Sinonasal Wound Healing

2015 ◽  
Vol 24 (15) ◽  
pp. 1817-1830 ◽  
Author(s):  
Jing Li ◽  
Chun-Quan Zheng ◽  
Yong Li ◽  
Chen Yang ◽  
Hai Lin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Mesenchymal Stem Cells ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Factor Gene ◽  
Growth Factor Gene ◽  
Hepatocyte Growth

Hepatocyte Growth Factor Gene-Modified Mesenchymal Stem Cells Reduce Radiation-Induced Lung Injury

2013 ◽  
Vol 24 (3) ◽  
pp. 343-353 ◽  
Author(s):  
Hua Wang ◽  
Yue-Feng Yang ◽  
Li Zhao ◽  
Feng-Jun Xiao ◽  
Qun-Wei Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Growth Factor ◽  
Lung Injury ◽  
Hepatocyte Growth Factor ◽  
Factor Gene ◽  
Growth Factor Gene ◽  
Radiation Induced ◽  
Hepatocyte Growth

scholarly journals Hepatocyte Growth Factor Effects on Mesenchymal Stem Cells Derived from Human Arteries: A Novel Strategy to Accelerate Vascular Ulcer Wound Healing

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Sabrina Valente ◽  
Carmen Ciavarella ◽  
Emanuela Pasanisi ◽  
Francesca Ricci ◽  
Andrea Stella ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Mesenchymal Stem Cells ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Biological Activities ◽  
Healing Process ◽  
Wound Healing Process ◽  
Human Arteries ◽  
Hepatocyte Growth

Vascular ulcers are a serious complication of peripheral vascular disease, especially in diabetics. Several approaches to treat the wounds are proposed but they show poor outcomes and require long healing times. Hepatocyte Growth Factor/Scatter Factor (HGF/SF) is a pleiotropic cytokine exerting many biological activities through the c-Met receptor. This study was aimed at verifying whether HGF/SF influences proliferation, migration, and angiogenesis on mesenchymal stem cells isolated from human arteries (hVW-MSCs). hVW-MSCs were exposed to NIBSC HGF/SF (2.5, 5, 10, and 70 ng/mL) from 6 hrs to 7 days. HGF and c-MET mRNA and protein expression, cell proliferation (Alamar Blue and Ki–67 assay), migration (scratch and transwell assays), and angiogenesis (Matrigel) were investigated. hVW-MSCs displayed stemness features and expressed HGF and c-MET. HGF/SF did not increase hVW-MSC proliferation, whereas it enhanced the cell migration, the formation of capillary-like structures, and the expression of angiogenic markers (vWF, CD31, and KDR). The HGF/SF effects on hVW-MSC migration and angiogenic potential are of great interest to accelerate wound healing process. Local delivery of HGF/SF could therefore improve the healing of unresponsive vascular ulcers.

Sign in / Sign up

Export Citation Format

Share Document