scholarly journals Multi-Drug Resistance ABC Transporter Inhibition Enhances Murine Ventral Prostate Stem/Progenitor Cell Differentiation

2015 ◽  
Vol 24 (10) ◽  
pp. 1236-1251 ◽  
Author(s):  
Mugdha D. Samant ◽  
Courtney M. Jackson ◽  
Carina L. Felix ◽  
Anthony J. Jones ◽  
David W. Goodrich ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Cell Differentiation ◽  
Abc Transporter ◽  
Progenitor Cell ◽  
Ventral Prostate ◽  
Multi Drug Resistance

Mutations of the multi-drug resistance-associated protein ABC transporter gene 5 result in reduction of phytic acid in rice seeds

2009 ◽  
Vol 119 (1) ◽  
pp. 75-83 ◽  
Author(s):  
Xiu-Hong Xu ◽  
Hai-Jun Zhao ◽  
Qing-Long Liu ◽  
Thomas Frank ◽  
Karl-Heinz Engel ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Phytic Acid ◽  
Abc Transporter ◽  
Multi Drug Resistance ◽  
Transporter Gene ◽  
Rice Seeds

scholarly journals Structural basis for the mechanism of ABC transporters

2015 ◽  
Vol 43 (5) ◽  
pp. 889-893 ◽  
Author(s):  
Konstantinos Beis
Keyword(s):  
Drug Resistance ◽  
Binding Site ◽  
Abc Transporter ◽  
Abc Transporters ◽  
Eukaryotic Cells ◽  
Structural Basis ◽  
Multi Drug Resistance ◽  
Hydrolysis Of ◽  
Transport Molecules ◽  
Alternating Access

The ATP-binding cassette (ABC) transporters are primary transporters that couple the energy stored in adenosine triphosphate (ATP) to the movement of molecules across the membrane. ABC transporters can be divided into exporters and importers; importers mediate the uptake of essential nutrients into cells and are found predominantly in prokaryotes whereas exporters transport molecules out of cells or into organelles and are found in all organisms. ABC exporters have been linked with multi-drug resistance in both bacterial and eukaryotic cells. ABC transporters are powered by the hydrolysis of ATP and transport their substrate via the alternating access mechanism, whereby the protein alternates between a conformation in which the substrate-binding site is accessible from the outside of the membrane, outward-facing and one in which it is inward-facing. In this mini-review, the structures of different ABC transporter types in different conformations are presented within the context of the alternating access mechanism and how they have shaped our current understanding of the mechanism of ABC transporters.

Strategies to Overcome Multi-Drug Resistance in Cancer Cells: the Contribution of siRNA and Nanotechnologies

2016 ◽  
Vol 20 (28) ◽  
pp. 2971-2982
Author(s):  
Cristina Mambet ◽  
Mihaela Chivu-Economescu ◽  
Lilia Matei ◽  
Mihai Stoian ◽  
Coralia Bleotu
Keyword(s):  
Drug Resistance ◽  
Cancer Cells ◽  
Multi Drug Resistance
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