scholarly journals Human Cerebrospinal Fluid Regulates Proliferation and Migration of Stem Cells Through Insulin-Like Growth Factor-1

2015 ◽  
Vol 24 (2) ◽  
pp. 160-171 ◽  
Author(s):  
Mingxin Zhu ◽  
Yun Feng ◽  
Sean Dangelmajer ◽  
Hugo Guerrero-Cázares ◽  
Kaisorn L. Chaichana ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cerebrospinal Fluid ◽  
Growth Factor ◽  
Insulin Like Growth Factor ◽  
Human Cerebrospinal Fluid ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals Isolation from human cerebrospinal fluid of a new insulin-like growth factor-binding protein with a selective affinity for IGF-II

FEBS Letters ◽  
1989 ◽  
Vol 255 (2) ◽  
pp. 253-258 ◽  
Author(s):  
Monireh Roghani ◽  
Paul Hossenlopp ◽  
Pierre Lepage ◽  
Alain Balland ◽  
Michel Binoux
Keyword(s):  
Cerebrospinal Fluid ◽  
Growth Factor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Binding ◽  
Human Cerebrospinal Fluid

scholarly journals Up-Regulation of Insulin-Like Growth Factor-2 Promotes Cell Proliferation and Migration and is Associated with Bone Metastasis in Non Small Cell Lung Cancer.

2021 ◽  
Author(s):  
Shuai Han ◽  
Zhenhua Wang ◽  
Guangjian Bai ◽  
Zhitao Han ◽  
Yunpeng Bai ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Growth Factor ◽  
Bone Metastasis ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Insulin Like Growth Factor ◽  
Small Cell Lung ◽  
And Migration ◽  
Proliferation And Migration

Abstract Background:Non-small cell lung cancer (NSCLC) is a malignant tumor with high morbidity and mortality. About 40% NSCLC patients develop bone metastasis. The aberrant expression of IGF2 (insulin-like growth factor-2) is known to be linked with many malignancies, but it has not been reported in NSCLC. Methods and Results:We first used the GEO database for differential gene analysis and showed a correlation between IGF2 and bone metastasis in NSCLC. IGF2 was highly expressed in primary NSCLC and even more highly expressed in bone metastases. Our in vivo experiment also showed that IGF2 promoted lung cancer proliferation and migration. In addition, IGF2 overexpression activated AKT/NF-κB pathway by promoting IGF1R and INSR phosphorylation, and enhanced osteolytic lesions in lung cancer.Conclusions：Up-regulation of insulin-like growth factor-2 can promote the proliferation and migration of non-small cell lung cancer cells, and is related to bone metastasis.

scholarly journals The Influence of Curcumin on the Downregulation of MYC, Insulin and IGF-1 Receptors: A possible Mechanism Underlying the Anti-Growth and Anti-Migration in Chemoresistant Colorectal Cancer Cells

Medicina ◽  
2019 ◽  
Vol 55 (4) ◽  
pp. 90 ◽  
Author(s):  
Seyed Ahmad Hosseini ◽  
Hamid Zand ◽  
Makan Cheraghpour
Keyword(s):  
Colorectal Cancer ◽  
Growth Factor ◽  
Cancer Cells ◽  
Insulin Like Growth Factor ◽  
Anticancer Properties ◽  
Colorectal Cancer Cells ◽  
Cellular Homolog ◽  
And Migration ◽  
Migration Capacity ◽  
Proliferation And Migration

Background and objectives: Mounting evidence shows that curcumin, a bioactive substance originating from turmeric root, has anticancer properties. Additionally, curcumin prevents the migration and metastasis of tumor cells. However, the molecular mechanism involved in the anti-metastatic action of curcumin is not clear. Most studies have suggested that migration inhibition is related to curcumin’s anti-inflammatory properties. Curcumin possesses a regulatory effect on insulin and insulin-like growth factor-1 (IGF-1) receptors and signaling. Insulin signaling is one of the important pathways involved in tumor initiation and progression; therefore, we proposed that the anti-metastatic effect of curcumin may mediate the downregulation of insulin and insulin-like growth factor-1 receptors. Materials and Methods: Viable resistant cells resulting from treating SW480 cells with 5-fluorouracil (5-FU) were subjected to curcumin treatment to analyze the proliferation and migration capacity in comparison to the untreated counterparts. To test the proliferation and migration potential, MTT, colony formation, and wound healing assays were performed. Real-time polymerase chain reaction (RT-PCR) was performed to measure the mRNA expression of insulin-like growth factor-1R (IGF-1R), insulin receptor (IR), and avian myelocytomatosis virus oncogene cellular homolog (MYC). Results: Our findings showed that curcumin significantly decreased insulin and IGF-1 receptors in addition to MYC expression. Additionally, the downregulation of the insulin and insulin-like growth factor-1 receptors was correlated to a greater decrease in the proliferation and migration of chemoresistant colorectal cancer cells. Conclusions: These results suggest the possible therapeutic effectiveness of curcumin in adjuvant therapy in metastatic colorectal cancer.

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