Zinc Finger DHHC-Type Containing 13 Regulates Fate Specification of Ectoderm and Mesoderm Cell Lineages by Modulating Smad6 Activity

2014 ◽  
Vol 23 (16) ◽  
pp. 1899-1909 ◽  
Author(s):  
Xueran Chen ◽  
Wei Shi ◽  
Fen Wang ◽  
Zhaoxia Du ◽  
Yang Yang ◽  
...  
Keyword(s):  
Zinc Finger ◽  
Mesoderm Cell ◽  
Fate Specification ◽  
Cell Lineages

ming is expressed in neuroblast sublineages and regulates gene expression in the Drosophila central nervous system

Development ◽  
1992 ◽  
Vol 116 (4) ◽  
pp. 943-952 ◽  
Author(s):  
X. Cui ◽  
C.Q. Doe
Keyword(s):  
Gene Expression ◽  
Central Nervous System ◽  
Nervous System ◽  
Cell Fate ◽  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Cell Lineage ◽  
Cell Lineages ◽  
Finger Protein ◽  
Cell Diversity

Cell diversity in the Drosophila central nervous system (CNS) is primarily generated by the invariant lineage of neural precursors called neuroblasts. We used an enhancer trap screen to identify the ming gene, which is transiently expressed in a subset of neuroblasts at reproducible points in their cell lineage (i.e. in neuroblast ‘sublineages’), suggesting that neuroblast identity can be altered during its cell lineage. ming encodes a predicted zinc finger protein and loss of ming function results in precise alterations in CNS gene expression, defects in axonogenesis and embryonic lethality. We propose that ming controls cell fate within neuroblast cell lineages.

scholarly journals Shaping of Drosophila Neural Cell Lineages Through Coordination of Cell Proliferation and Cell Fate by the BTB-ZF Transcription Factor Tramtrack-69

Genetics ◽  
2019 ◽  
Vol 212 (3) ◽  
pp. 773-788
Author(s):  
Françoise Simon ◽  
Anne Ramat ◽  
Sophie Louvet-Vallée ◽  
Jérôme Lacoste ◽  
Angélique Burg ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
Transcription Factor ◽  
Cell Fate ◽  
Zinc Finger ◽  
Molecular Mechanisms ◽  
Neural Cell ◽  
Cell Cycle Exit ◽  
Cell Lineages ◽  
Accessory Cells

Cell diversity in multicellular organisms relies on coordination between cell proliferation and the acquisition of cell identity. The equilibrium between these two processes is essential to assure the correct number of determined cells at a given time at a given place. Using genetic approaches and correlative microscopy, we show that Tramtrack-69 (Ttk69, a Broad-complex, Tramtrack and Bric-à-brac - Zinc Finger (BTB-ZF) transcription factor ortholog of the human promyelocytic leukemia zinc finger factor) plays an essential role in controlling this balance. In the Drosophila bristle cell lineage, which produces the external sensory organs composed by a neuron and accessory cells, we show that ttk69 loss-of-function leads to supplementary neural-type cells at the expense of accessory cells. Our data indicate that Ttk69 (1) promotes cell cycle exit of newborn terminal cells by downregulating CycE, the principal cyclin involved in S-phase entry, and (2) regulates cell-fate acquisition and terminal differentiation, by downregulating the expression of hamlet and upregulating that of Suppressor of Hairless, two transcription factors involved in neural-fate acquisition and accessory cell differentiation, respectively. Thus, Ttk69 plays a central role in shaping neural cell lineages by integrating molecular mechanisms that regulate progenitor cell cycle exit and cell-fate commitment.

scholarly journals Arabidopsis BIRD Zinc Finger Proteins Jointly Stabilize Tissue Boundaries by Confining the Cell Fate Regulator SHORT-ROOT and Contributing to Fate Specification

2015 ◽  
Vol 27 (4) ◽  
pp. 1185-1199 ◽  
Author(s):  
Yuchen Long ◽  
Wouter Smet ◽  
Alfredo Cruz-Ramírez ◽  
Bas Castelijns ◽  
Wim de Jonge ◽  
...  
Keyword(s):  
Cell Fate ◽  
Zinc Finger ◽  
Zinc Finger Proteins ◽  
Short Root ◽  
Fate Specification

scholarly journals Divergent mechanisms regulate conserved cardiopharyngeal development and gene expression in distantly related ascidians

eLife ◽  
2014 ◽  
Vol 3 ◽  
Author(s):  
Alberto Stolfi ◽  
Elijah K Lowe ◽  
Claudia Racioppi ◽  
Filomena Ristoratore ◽  
C Titus Brown ◽  
...  
Keyword(s):  
Gene Expression ◽  
Expression Patterns ◽  
Embryonic Cell ◽  
Regulatory Mechanisms ◽  
Regulatory Sequences ◽  
Pharyngeal Muscle ◽  
Fate Specification ◽  
Cell Lineages ◽  
Identical Cell ◽  
Cis And Trans

Ascidians present a striking dichotomy between conserved phenotypes and divergent genomes: embryonic cell lineages and gene expression patterns are conserved between distantly related species. Much research has focused on Ciona or Halocynthia spp. but development in other ascidians remains poorly characterized. In this study, we surveyed the multipotent myogenic B7.5 lineage in Molgula spp. Comparisons to the homologous lineage in Ciona revealed identical cell division and fate specification events that result in segregation of larval, cardiac, and pharyngeal muscle progenitors. Moreover, the expression patterns of key regulators are conserved, but cross-species transgenic assays uncovered incompatibility, or ‘unintelligibility’, of orthologous cis-regulatory sequences between Molgula and Ciona. These sequences drive identical expression patterns that are not recapitulated in cross-species assays. We show that this unintelligibility is likely due to changes in both cis- and trans-acting elements, hinting at widespread and frequent turnover of regulatory mechanisms underlying otherwise conserved aspects of ascidian embryogenesis.

scholarly journals Contact-dependent cell-cell communications drive morphological invariance during ascidian embryogenesis

2017 ◽  
Author(s):  
Léo Guignard ◽  
Ulla-Maj Fiuza ◽  
Bruno Leggio ◽  
Emmanuel Faure ◽  
Julien Laussu ◽  
...  
Keyword(s):  
Individual Cell ◽  
Inverse Correlation ◽  
Light Sheet ◽  
Embryonic Cell ◽  
Cell Behaviors ◽  
Fate Specification ◽  
Cell Lineages ◽  
Genomic Divergence ◽  
Dependent Cell ◽  
Local Cell

ABSTRACTCanalization of developmental processes ensures the reproducibility and robustness of embryogenesis within each species. In its extreme form, found in ascidians, early embryonic cell lineages are invariant between embryos within and between species, despite rapid genomic divergence. To resolve this paradox, we used live light-sheet imaging to quantify individual cell behaviors in digitalized embryos and explore the forces that canalize their development. This quantitative approach revealed that individual cell geometries and cell contacts are strongly constrained, and that these constraints are tightly linked to the control of fate specification by local cell inductions. While in vertebrates ligand concentration usually controls cell inductions, we found that this role is fulfilled in ascidians by the area of contacts between signaling and responding cells. We propose that the duality between geometric and genetic control of inductions contributes to the counterintuitive inverse correlation between geometric and genetic variability during embryogenesis.

scholarly journals Polycomb Regulates Mesoderm Cell Fate-Specification in Embryonic Stem Cells through Activation and Repression Mechanisms

2015 ◽  
Vol 17 (3) ◽  
pp. 300-315 ◽  
Author(s):  
Lluis Morey ◽  
Alexandra Santanach ◽  
Enrique Blanco ◽  
Luigi Aloia ◽  
Elphège P. Nora ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Cell Fate ◽  
Embryonic Stem ◽  
Cell Fate Specification ◽  
Mesoderm Cell ◽  
Fate Specification

scholarly journals FOG-2, a Heart- and Brain-Enriched Cofactor for GATA Transcription Factors

1999 ◽  
Vol 19 (6) ◽  
pp. 4495-4502 ◽  
Author(s):  
Jian-rong Lu ◽  
Timothy A. McKinsey ◽  
Hongtao Xu ◽  
Da-zhi Wang ◽  
James A. Richardson ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcription Factors ◽  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Cell Types ◽  
Hematopoietic Cell ◽  
Related Factor ◽  
Control Of Gene Expression ◽  
Cell Lineages ◽  
Gata Transcription Factors

ABSTRACT Members of the GATA family of zinc finger transcription factors have been shown to play important roles in the control of gene expression in a variety of cell types. GATA-1, -2, and -3 are expressed primarily in hematopoietic cell lineages and are required for proliferation and differentiation of multiple hematopoietic cell types, whereas GATA-4, -5, and -6 are expressed in the heart, where they activate cardiac muscle structural genes. Friend of GATA-1 (FOG) is a multitype zinc finger protein that interacts with GATA-1 and serves as a cofactor for GATA-1-mediated transcription. FOG is coexpressed with GATA-1 in developing erythroid and megakaryocyte cell lineages and cooperates with GATA-1 to control erythropoiesis. We describe a novel FOG-related factor, FOG-2, that is expressed predominantly in the developing and adult heart, brain, and testis. FOG-2 interacts with GATA factors, and interaction of GATA-4 and FOG-2 results in either synergistic activation or repression of GATA-dependent cardiac promoters, depending on the specific promoter and the cell type in which they are tested. The properties of FOG-2 suggest its involvement in the control of cardiac and neural gene expression by GATA transcription factors.

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