scholarly journals Polycomb Group Protein Bmi1 Promotes Hematopoietic Cell Development from Embryonic Stem Cells

2012 ◽  
Vol 21 (1) ◽  
pp. 121-132 ◽  
Author(s):  
Xiaolei Ding ◽  
Qiong Lin ◽  
Roberto Ensenat-Waser ◽  
Stefan Rose-John ◽  
Martin Zenke
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Cell Development ◽  
Polycomb Group ◽  
Hematopoietic Cell ◽  
Polycomb Group Protein ◽  
Group Protein

scholarly journals The polycomb group protein Yaf2 regulates the pluripotency of embryonic stem cells in a phosphorylation-dependent manner

2018 ◽  
Vol 293 (33) ◽  
pp. 12793-12804 ◽  
Author(s):  
Wukui Zhao ◽  
Mengjie Liu ◽  
Haijing Ji ◽  
Yaru Zhu ◽  
Congcong Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Polycomb Group ◽  
Dependent Manner ◽  
Polycomb Group Protein ◽  
Group Protein

scholarly journals Loss of Polycomb Group Protein Pcgf1 Severely Compromises Proper Differentiation of Embryonic Stem Cells

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Yun Yan ◽  
Wukui Zhao ◽  
Yikai Huang ◽  
Huan Tong ◽  
Yin Xia ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Polycomb Group ◽  
Polycomb Group Protein ◽  
Group Protein

scholarly journals Deletion of the Polycomb-Group Protein EZH2 Leads to Compromised Self-Renewal and Differentiation Defects in Human Embryonic Stem Cells

Cell Reports ◽  
2016 ◽  
Vol 17 (10) ◽  
pp. 2700-2714 ◽  
Author(s):  
Adam Collinson ◽  
Amanda J. Collier ◽  
Natasha P. Morgan ◽  
Arnold R. Sienerth ◽  
Tamir Chandra ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Polycomb Group ◽  
Polycomb Group Protein ◽  
Self Renewal ◽  
Group Protein

scholarly journals A lineage-specific requirement for YY1 Polycomb Group protein function in early T cell development

Development ◽  
2021 ◽  
Vol 148 (7) ◽  
Author(s):  
Anna L. F. V. Assumpção ◽  
Guoping Fu ◽  
Deependra K. Singh ◽  
Zhanping Lu ◽  
Ashley M. Kuehnl ◽  
...  
Keyword(s):  
T Cell ◽  
Protein Function ◽  
Transcriptional Repression ◽  
T Cell Development ◽  
Cell Development ◽  
Polycomb Group ◽  
Conditional Knockout ◽  
Specific Requirement ◽  
Polycomb Group Protein ◽  
Group Protein

ABSTRACT Yin Yang 1 (YY1) is a ubiquitous transcription factor and mammalian Polycomb Group protein (PcG) with important functions for regulating lymphocyte development and stem cell self-renewal. YY1 mediates stable PcG-dependent transcriptional repression via recruitment of PcG proteins that result in histone modifications. Many questions remain unanswered regarding how cell- and tissue-specificity is achieved by PcG proteins. Here, we demonstrate that a conditional knockout of Yy1 in the hematopoietic system results in an early T cell developmental blockage at the double negative (DN) 1 stage with reduced Notch1 signaling. There is a lineage-specific requirement for YY1 PcG function. YY1 PcG domain is required for T and B cell development but not necessary for myeloid cells. YY1 functions in early T cell development are multicomponent and involve both PcG-dependent and -independent regulations. Although YY1 promotes early T cell survival through its PcG function, its function to promote the DN1-to-DN2 transition and Notch1 expression and signaling is independent of its PcG function. Our results reveal how a ubiquitously expressed PcG protein mediates lineage-specific and context-specific functions to control early T cell development.

scholarly journals Differentiation of Neural Stem Cells into Oligodendrocytes: Involvement of the Polycomb Group Protein Ezh2

Stem Cells ◽  
2008 ◽  
Vol 26 (11) ◽  
pp. 2875-2883 ◽  
Author(s):  
Falak Sher ◽  
Reinhard Rößler ◽  
Nieske Brouwer ◽  
Veerakumar Balasubramaniyan ◽  
Erik Boddeke ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Polycomb Group ◽  
Polycomb Group Protein ◽  
Group Protein

scholarly journals Generation of Functional Thymic Epithelium from Human Embryonic Stem Cells that Supports Host T Cell Development

2013 ◽  
Vol 13 (2) ◽  
pp. 219-229 ◽  
Author(s):  
Audrey V. Parent ◽  
Holger A. Russ ◽  
Imran S. Khan ◽  
Taylor N. LaFlam ◽  
Todd C. Metzger ◽  
...  
Keyword(s):  
Stem Cells ◽  
T Cell ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
T Cell Development ◽  
Embryonic Stem ◽  
Cell Development ◽  
Thymic Epithelium

scholarly journals The Polycomb group protein CBX6 is an essential regulator of embryonic stem cell identity

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Alexandra Santanach ◽  
Enrique Blanco ◽  
Hua Jiang ◽  
Kelly R. Molloy ◽  
Miriam Sansó ◽  
...  
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Polycomb Group ◽  
Polycomb Group Protein ◽  
Cell Identity ◽  
Group Protein
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