scholarly journals Fetal Cells in the Murine Maternal Lung Have Well-Defined Characteristics and Are Preferentially Located in Alveolar Septum

2012 ◽  
Vol 21 (1) ◽  
pp. 158-165 ◽  
Author(s):  
Kirby L. Johnson ◽  
Helene Stroh ◽  
Serkalem Tadesse ◽  
Errol R. Norwitz ◽  
Lauren Richey ◽  
...  
Keyword(s):  
Fetal Cells ◽  
Alveolar Septum

scholarly journals SARS-CoV-2 colonization of maternal and fetal cells of the human placenta promotes alteration of local renin-angiotensin system

Med ◽  
2021 ◽  
Author(s):  
Sonam Verma ◽  
Chetanchandra S. Joshi ◽  
Rachel B. Silverstein ◽  
Mai He ◽  
Ebony B. Carter ◽  
...  
Keyword(s):  
Human Placenta ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Fetal Cells

scholarly journals Development of a Specific Monoclonal Antibody to Detect Male Cells Expressing the RPS4Y1 Protein

2021 ◽  
Vol 22 (4) ◽  
pp. 2001
Author(s):  
Silvia Spena ◽  
Chiara Cordiglieri ◽  
Isabella Garagiola ◽  
Flora Peyvandi
Keyword(s):  
Monoclonal Antibody ◽  
Prenatal Diagnosis ◽  
Maternal Blood ◽  
Limiting Factors ◽  
Inherited Disease ◽  
Specific Monoclonal Antibody ◽  
Native Form ◽  
Fetal Cells ◽  
Non Invasive ◽  
Reliable Isolation

Hemophilia is an X-linked recessive bleeding disorder. In pregnant women carrier of hemophilia, the fetal sex can be determined by non-invasive analysis of fetal DNA circulating in the maternal blood. However, in case of a male fetus, conventional invasive procedures are required for the diagnosis of hemophilia. Fetal cells, circulating in the maternal bloodstream, are an ideal target for a safe non-invasive prenatal diagnosis. Nevertheless, the small number of cells and the lack of specific fetal markers have been the most limiting factors for their isolation. We aimed to develop monoclonal antibodies (mAbs) against the ribosomal protein RPS4Y1 expressed in male cells. By Western blotting, immunoprecipitation and immunofluorescence analyses performed on cell lysates from male human hepatoma (HepG2) and female human embryonic kidney (HEK293) we developed and characterized a specific monoclonal antibody against the native form of the male RPS4Y1 protein that can distinguish male from female cells. The availability of the RPS4Y1-targeting monoclonal antibody should facilitate the development of novel methods for the reliable isolation of male fetal cells from the maternal blood and their future use for non-invasive prenatal diagnosis of X-linked inherited disease such as hemophilia.

Trophic influences of human and rat amniotic fluid on neural tube-derived rat fetal cells

1993 ◽  
Vol 11 (3) ◽  
pp. 347-355 ◽  
Author(s):  
Jorge A. Colombo ◽  
Mónica Napp ◽  
Juan R. Depaoli ◽  
Virginia Puissant
Keyword(s):  
Amniotic Fluid ◽  
Neural Tube ◽  
Fetal Cells

Ganciclovir Transfer by Human Placenta and Its Effects on Rat Fetal Cells

1993 ◽  
Vol 306 (3) ◽  
pp. 151-156 ◽  
Author(s):  
George I. Henderson ◽  
Zhie Q. Hu ◽  
Y. Yang ◽  
Tony B. Perez ◽  
Bheemappa G. Devi ◽  
...  
Keyword(s):  
Human Placenta ◽  
Fetal Cells

scholarly journals 805: Senescent fetal cells signal human parturition

2016 ◽  
Vol 214 (1) ◽  
pp. S420
Author(s):  
Faranak Behnia ◽  
George Saade ◽  
Ramkumar Menon
Keyword(s):  
Fetal Cells ◽  
Human Parturition
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