Derivation of Cloned Human Blastocysts by Histone Deacetylase Inhibitor Treatment After Somatic Cell Nuclear Transfer with β-Thalassemia Fibroblasts

2011 ◽  
Vol 20 (11) ◽  
pp. 1951-1959 ◽  
Author(s):  
Yong Fan ◽  
Yonghua Jiang ◽  
Xinjie Chen ◽  
Zhanhui Ou ◽  
Yifei Yin ◽  
...  
Keyword(s):  
Somatic Cell ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Somatic Cell Nuclear Transfer ◽  
Nuclear Transfer ◽  
Deacetylase Inhibitor ◽  
Inhibitor Treatment

scholarly journals Effects of Histone Deacetylase Inhibitor Oxamflatin onIn VitroPorcine Somatic Cell Nuclear Transfer Embryos

2014 ◽  
Vol 16 (4) ◽  
pp. 253-265 ◽  
Author(s):  
Liming Hou ◽  
Fanhua Ma ◽  
Jinzeng Yang ◽  
Hasan Riaz ◽  
Yongliang Wang ◽  
...  
Keyword(s):  
Somatic Cell ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Somatic Cell Nuclear Transfer ◽  
Nuclear Transfer ◽  
Deacetylase Inhibitor

Production of somatic cell nuclear transfer embryos using in vitro-grown and in vitro-matured oocytes in rabbits

Zygote ◽  
2014 ◽  
Vol 23 (4) ◽  
pp. 494-500 ◽  
Author(s):  
Hironobu Sugimoto ◽  
Yuta Kida ◽  
Noriyoshi Oh ◽  
Kensaku Kitada ◽  
Kazuya Matsumoto ◽  
...  
Keyword(s):  
Somatic Cell ◽  
Histone Deacetylase Inhibitor ◽  
Somatic Cell Nuclear Transfer ◽  
Nuclear Transfer ◽  
Trichostatin A ◽  
Blastocyst Stage ◽  
Developmental Competence ◽  
Deacetylase Inhibitor ◽  
Number Of Cells

SummaryWe examined growing oocytes collected from follicles remaining in superovulated rabbit ovaries, that were grown (in vitro growth, IVG) and matured (in vitro maturation, IVM) in vitro. We produced somatic cell nuclear transfer (SCNT) embryos using the mature oocytes and examined whether these embryos have the ability to develop to the blastocyst stage. In addition, we examined the effects of trichostatin A (TSA), a histone deacetylase inhibitor (HDACi), on the developmental competence of SCNT embryos derived from IVG–IVM oocytes. After growth for 7 days and maturation for 14–16 h in vitro, the growing oocytes reached the metaphase II stage (51.4%). After SCNT, these reconstructed embryos reached the blastocyst stage (20%). Furthermore, the rate of development to the blastocyst stage and the number of cells in the blastocysts in SCNT embryos derived from IVG–IVM oocytes were significantly higher for TSA-treated embryos compared with TSA-untreated embryos (40.6 versus 21.4% and 353.1 ± 59.1 versus 202.5 ± 54.6, P < 0.05). These results indicate that rabbit SCNT embryos using IVG–IVM oocytes have the developmental competence to reach the blastocyst stage.

scholarly journals Low-Dose Histone Deacetylase Inhibitor Treatment Leads to Tumor Growth Arrest and Multi-Lineage Differentiation of Malignant Rhabdoid Tumors

2016 ◽  
Vol 22 (14) ◽  
pp. 3560-3570 ◽  
Author(s):  
Andrea Muscat ◽  
Dean Popovski ◽  
W. Samantha N. Jayasekara ◽  
Fernando J. Rossello ◽  
Melissa Ferguson ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Low Dose ◽  
Growth Arrest ◽  
Lineage Differentiation ◽  
Deacetylase Inhibitor ◽  
Rhabdoid Tumors ◽  
Inhibitor Treatment

scholarly journals Histone deacetylase inhibitor treatment attenuates coagulation imbalance in a lethal murine model of sepsis

Surgery ◽  
2014 ◽  
Vol 156 (2) ◽  
pp. 214-220 ◽  
Author(s):  
Ting Zhao ◽  
Yongqing Li ◽  
Baoling Liu ◽  
Erxi Wu ◽  
Martin Sillesen ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Murine Model ◽  
Histone Deacetylase Inhibitor ◽  
Deacetylase Inhibitor ◽  
Inhibitor Treatment
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