Human Amniotic Fluid Promotes Retinal Pigmented Epithelial Cells' Trans-Differentiation into Rod Photoreceptors and Retinal Ganglion Cells

2011 ◽  
Vol 20 (9) ◽  
pp. 1615-1625 ◽  
Author(s):  
Shima Ghaderi ◽  
Zahra-Soheila Soheili ◽  
Hamid Ahmadieh ◽  
Maliheh Davari ◽  
Fatemeh Sanie Jahromi ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Amniotic Fluid ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Human Amniotic Fluid ◽  
Rod Photoreceptors ◽  
Retinal Pigmented Epithelial Cells

scholarly journals A feed-forward regulation of endothelin receptors by c-Jun in human non-pigmented ciliary epithelial cells and retinal ganglion cells

PLoS ONE ◽  
2017 ◽  
Vol 12 (9) ◽  
pp. e0185390 ◽  
Author(s):  
Junming Wang ◽  
Hai-Ying Ma ◽  
Raghu R. Krishnamoorthy ◽  
Thomas Yorio ◽  
Shaoqing He
Keyword(s):  
Epithelial Cells ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Endothelin Receptors ◽  
Retinal Ganglion ◽  
Feed Forward

scholarly journals Activation of rod input in a model of retinal degeneration reverses retinal remodeling and induces formation of normal synapses, circuitry and visual signaling in the adult retina

2018 ◽  
Author(s):  
Tian Wang ◽  
Johan Pahlberg ◽  
Jon Cafaro ◽  
Alapakkam P. Sampath ◽  
Greg D. Field ◽  
...  
Keyword(s):  
Synaptic Transmission ◽  
Retinal Ganglion Cells ◽  
Bipolar Cell ◽  
Ganglion Cells ◽  
Bipolar Cells ◽  
Mouse Retina ◽  
Retinal Ganglion ◽  
Rod Photoreceptors ◽  
Retinal Remodeling ◽  
Rod Bipolar Cells

AbstractA major cause of human blindness is the death of rod photoreceptors. As rods degenerate, synaptic structures between rod and rod bipolar cells dissolve and the rod bipolar cells extend their dendrites and occasionally make aberrant contacts. Such changes are broadly observed in blinding disorders caused by photoreceptor cell death and is thought to occur in response to deafferentation. How the remodeled retinal circuit affect visual processing following rod rescue is not known. To address this question, we generated transgenic mice wherein a disrupted cGMP-gated channel (CNG) gene can be repaired at the endogenous locus and at different stages of degeneration by tamoxifen-inducible cre-mediated recombination. In normal rods, light-induced closure of CNG channels leads to hyperpolarization of the cell, reducing neurotransmitter release at the synapse. Similarly, rods lacking CNG channel exhibit a resting membrane potential that was ~10mV hyperpolarized compared to WT rods, indicating diminished glutamate release. Retinas from these mice undergo stereotypic retinal remodeling as a consequence of rod malfunction and degeneration. Upon tamoxifen-induced expression of CNG channels, rods recovered their structure and exhibited normal light responses. Moreover, we show that the adult mouse retina displays a surprising degree of plasticity upon activation of rod input. Wayward bipolar cell dendrites establish contact with rods to support normal synaptic transmission, which is propagated to the retinal ganglion cells. These findings demonstrate remarkable plasticity extending beyond the developmental period and support efforts to repair or replace defective rods in patients blinded by rod degeneration.Significance StatementCurrent strategies for treatment of neurodegenerative disorders are focused on the repair of the primary affected cell type. However, the defective neuron functions within a complex neural circuitry, which also becomes degraded during disease. It is not known whether a rescued neuron and the remodeled circuit will establish communication to regain normal function. We show that the adult mammalian neural retina exhibits a surprising degree of plasticity following rescue of rod photoreceptors. The wayward rod bipolar cell dendrites re-establish contact with rods to support normal synaptic transmission, which is propagated to the retinal ganglion cells. These findings support efforts to repair or replace defective rods in patients blinded by rod cell loss.

Factors secreted by human amniotic epithelial cells promote the survival of rat retinal ganglion cells

2003 ◽  
Vol 341 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Saiko Uchida ◽  
Yasuyuki Suzuki ◽  
Makoto Araie ◽  
Kenji Kashiwagi ◽  
Yasumasa Otori ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Amniotic Epithelial Cells ◽  
Human Amniotic Epithelial Cells

Calcium Signals Induced By Tonic Firing In Rat Retinal Ganglion Cells

2012 ◽  
Vol 3 (1) ◽  
pp. 53-59 ◽  
Author(s):  
Kyril I. Kuznetsov ◽  
Vitaliy Yu. Maslov ◽  
Svetlana A. Fedulova ◽  
Nikolai S. Veselovsky
Keyword(s):  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Calcium Signals ◽  
Tonic Firing
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