Immunomodulatory Properties of Mesenchymal Stem Cells Derived from Dental Pulp and Dental Follicle are Susceptible to Activation by Toll-Like Receptor Agonists

2011 ◽  
Vol 20 (4) ◽  
pp. 695-708 ◽  
Author(s):  
Sergej Tomic ◽  
Jelena Djokic ◽  
Sasa Vasilijic ◽  
Dragana Vucevic ◽  
Vera Todorovic ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Dental Pulp ◽  
Dental Follicle ◽  
Toll Like Receptor ◽  
Receptor Agonists ◽  
Immunomodulatory Properties

Melatonin Treatment Alters Biological and Immunomodulatory Properties of Human Dental Pulp Mesenchymal Stem Cells Via Augmented TGFβ Secretion.

2020 ◽  
Author(s):  
David García-Bernal ◽  
Sergio López-García ◽  
José L. Sanz ◽  
Julia Guerrero-Gironés ◽  
Esther M. García-Navarro ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Dental Pulp ◽  
Melatonin Treatment ◽  
Human Dental Pulp ◽  
Immunomodulatory Properties

scholarly journals Characterization of mesenchymal stem cells under the stimulation of Toll‐like receptor agonists

2014 ◽  
Vol 56 (3) ◽  
pp. 233-244 ◽  
Author(s):  
Xi Chen ◽  
Zheng‐Yun Zhang ◽  
Hao Zhou ◽  
Guang‐Wen Zhou
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Toll Like Receptor ◽  
Receptor Agonists ◽  
Stimulation Of

Comparative analysis of the immunomodulatory properties of equine adult-derived mesenchymal stem cells

Cell Medicine ◽  
2012 ◽  
Author(s):  
Danielle D. Carrade ◽  
Michael W. Lame ◽  
Michael S. Kent ◽  
Kaitlin C. Clark ◽  
Naomi J. Walker ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Comparative Analysis ◽  
Immunomodulatory Properties

Comparing the osteogenic potential of schneiderian membrane and dental pulp mesenchymal stem cells: an in vitro study

2021 ◽  
Author(s):  
Antoine Berbéri ◽  
Joseph Sabbagh ◽  
Rita Bou Assaf ◽  
Michella Ghassibe-Sabbagh ◽  
Fatima Al-Nemer ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Dental Pulp ◽  
In Vitro Study ◽  
Vitro Study ◽  
Osteogenic Potential ◽  
Schneiderian Membrane

scholarly journals Dental Pulp-Derived Mesenchymal Stem Cells for Modeling Genetic Disorders

2021 ◽  
Vol 22 (5) ◽  
pp. 2269
Author(s):  
Keiji Masuda ◽  
Xu Han ◽  
Hiroki Kato ◽  
Hiroshi Sato ◽  
Yu Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Dental Pulp ◽  
Genetic Disorders ◽  
In Vitro Models ◽  
High Plasticity ◽  
Human Teeth ◽  
Clinical Diagnoses ◽  
Models Of Disease

A subpopulation of mesenchymal stem cells, developmentally derived from multipotent neural crest cells that form multiple facial tissues, resides within the dental pulp of human teeth. These stem cells show high proliferative capacity in vitro and are multipotent, including adipogenic, myogenic, osteogenic, chondrogenic, and neurogenic potential. Teeth containing viable cells are harvested via minimally invasive procedures, based on various clinical diagnoses, but then usually discarded as medical waste, indicating the relatively low ethical considerations to reuse these cells for medical applications. Previous studies have demonstrated that stem cells derived from healthy subjects are an excellent source for cell-based medicine, tissue regeneration, and bioengineering. Furthermore, stem cells donated by patients affected by genetic disorders can serve as in vitro models of disease-specific genetic variants, indicating additional applications of these stem cells with high plasticity. This review discusses the benefits, limitations, and perspectives of patient-derived dental pulp stem cells as alternatives that may complement other excellent, yet incomplete stem cell models, such as induced pluripotent stem cells, together with our recent data.

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