Irradiation of Adult Human Dental Pulp Stem Cells Provokes Activation of p53, Cell Cycle Arrest, and Senescence but Not Apoptosis

2010 ◽  
Vol 19 (12) ◽  
pp. 1855-1862 ◽  
Author(s):  
Darina Muthna ◽  
Tomas Soukup ◽  
Jirina Vavrova ◽  
Jaroslav Mokry ◽  
Jana Cmielova ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Cell Cycle Arrest ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Adult Human ◽  
Cycle Arrest ◽  
Human Dental Pulp

Pharmacological Notch pathway inhibition leads to cell cycle arrest and stimulates ascl1 and neurogenin2 genes expression in dental pulp stem cells-derived neurospheres

2019 ◽  
Vol 41 (6-7) ◽  
pp. 873-887 ◽  
Author(s):  
Ali Niapour ◽  
Hatef Ghasemi Hamidabadi ◽  
Nazila Niapour ◽  
Perham Mohammadi ◽  
Marzieh Sharifi Pasandi ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Cell Cycle Arrest ◽  
Dental Pulp ◽  
Notch Pathway ◽  
Dental Pulp Stem Cells ◽  
Cycle Arrest ◽  
Genes Expression ◽  
Pathway Inhibition

scholarly journals Efficient immortalization of human dental pulp stem cells with expression of cell cycle regulators with the intact chromosomal condition

PLoS ONE ◽  
2020 ◽  
Vol 15 (3) ◽  
pp. e0229996 ◽  
Author(s):  
Ai Orimoto ◽  
Seiko Kyakumoto ◽  
Takahiro Eitsuka ◽  
Kiyotaka Nakagawa ◽  
Tohru Kiyono ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Cell Cycle Regulators ◽  
Human Dental Pulp

scholarly journals The Protective Effect of Indole-3-Acetic Acid (IAA) on H2O2-Damaged Human Dental Pulp Stem Cells Is Mediated by the AKT Pathway and Involves Increased Expression of the Transcription Factor Nuclear Factor-Erythroid 2-Related Factor 2 (Nrf2) and Its Downstream Target Heme Oxygenase 1 (HO-1)

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Daehwan Kim ◽  
Hyewon Kim ◽  
Kichul Kim ◽  
Sangho Roh
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Acetic Acid ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Akt Pathway ◽  
Heme Oxygenase 1 ◽  
Related Factor ◽  
Human Dental Pulp ◽  
Indole 3 Acetic Acid

Indole-3-acetic acid (IAA) is the most common plant hormone of the auxin class and is known to have many effects including cell proliferation enhancement and antioxidant property. However, no study has revealed its defensive effects against oxidative toxicity in human dental pulp stem cells (hDPSCs). In this study, we investigated the effects of IAA on hydrogen peroxide- (H2O2-) induced oxidative toxicity in hDPSCs. H2O2-induced cytotoxicity was attenuated after IAA treatment. Cell cycle analysis using FACS showed that the damaged cell cycle and increased number of apoptotic cells by H2O2 treatment were recovered after the treatment of IAA. The H2O2-mediated increased expression of the proapoptotic genes, BAX and p53, was attenuated by IAA treatment, while IAA treatment increased antiapoptotic genes, BCL-2 and ATF5 expression. The increases of cleaved caspase-3 and ROS by H2O2 were also decreased after treatment of IAA. To further investigate the mechanism of IAA, Nrf2-related antioxidant pathway was examined and the results showed that the level of Nrf2 and HO-1 expressions, stimulated by H2O2, decreased after treatment of IAA. Moreover, IAA treatment protected hDPSCs against H2O2-induced oxidative stress via increased expression of Nrf2 and HO-1, mediated by the AKT pathway.

scholarly journals Implanted Adult Human Dental Pulp Stem Cells Induce Endogenous Axon Guidance

Stem Cells ◽  
2009 ◽  
Vol 27 (9) ◽  
pp. 2229-2237 ◽  
Author(s):  
Agnieszka Arthur ◽  
Songtao Shi ◽  
Andrew C. W. Zannettino ◽  
Nobutaka Fujii ◽  
Stan Gronthos ◽  
...  
Keyword(s):  
Stem Cells ◽  
Axon Guidance ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Adult Human ◽  
Human Dental Pulp

Adult Human Dental Pulp Stem Cells Differentiate Toward Functionally Active Neurons Under Appropriate Environmental Cues

Stem Cells ◽  
2008 ◽  
Vol 26 (7) ◽  
pp. 1787-1795 ◽  
Author(s):  
Agnes Arthur ◽  
Grigori Rychkov ◽  
Songtao Shi ◽  
Simon Andrea Koblar ◽  
Stan Gronthos
Keyword(s):  
Stem Cells ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Environmental Cues ◽  
Adult Human ◽  
Human Dental Pulp

Chrysin induces osteogenic differentiation of human dental pulp stem cells

2021 ◽  
Vol 400 (2) ◽  
pp. 112466
Author(s):  
J.F. Huo ◽  
M.L. Zhang ◽  
X.X. Wang ◽  
D.H. Zou
Keyword(s):  
Stem Cells ◽  
Osteogenic Differentiation ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Human Dental Pulp
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