scholarly journals Differentiation of Bone Marrow Mesenchymal Stem Cells into the Smooth Muscle Lineage by Blocking ERK/MAPK Signaling Pathway

2008 ◽  
Vol 17 (5) ◽  
pp. 897-908 ◽  
Author(s):  
Kenichi Tamama ◽  
Chandan K. Sen ◽  
Alan Wells
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Smooth Muscle ◽  
Signaling Pathway ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Erk Mapk ◽  
Marrow Mesenchymal Stem Cells

CKIP-1 contributes to osteogenic differentiation of mouse bone marrow mesenchymal stem cells

2021 ◽  
Vol 16 (9) ◽  
pp. 847-859
Author(s):  
Qiannan Niu ◽  
Shuning Shen ◽  
Jiaojiao He ◽  
Lei Wang
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Mouse Model ◽  
Signaling Pathway ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Negative Regulator ◽  
Mouse Bone Marrow ◽  
Marrow Mesenchymal Stem Cells

Background: Osteogenesis greatly depends on the differentiation of bone marrow mesenchymal stem cells (BMSCs). CKIP-1 is considered to be a negative regulator of BMSCs. Methods: We established a  CKIP-1 knockout mouse model, then isolated and cultured BMSCs from wild-type and knockout groups. Results: Our data demonstrated that CKIP-1 knockout significantly increased bone structure in the experimental mouse model and enhanced BMSC proliferation. CKIP-1 knockout contributed to osteoblastic and adipogenic differentiation. Furthermore, CKIP-1 regulated osteogenesis in BMSCs via the MAPK signaling pathway, and BMSCs from the  CKIP-1 knockout mice were effective in repairing the skull defect null mice. Conclusion: Our results concluded that silencing of CKIP-1 promoted osteogenesis in experimental mice and increased BMSCs differentiation via upregulation of the MAPK signaling pathway.

scholarly journals Strontium Promotes Osteogenic Differentiation of Mesenchymal Stem Cells Through the Ras/MAPK Signaling Pathway

2009 ◽  
Vol 23 (1-3) ◽  
pp. 165-174 ◽  
Author(s):  
Songlin Peng ◽  
Guangqian Zhou ◽  
Keith D.K. Luk ◽  
Kenneth M.C. Cheung ◽  
Zhaoyang Li ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Osteogenic Differentiation ◽  
Signaling Pathway ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway
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