Functional Drink Containing the Extracts of Purple Corn Cob and Pandan Leaves, the Novel Cognitive Enhancer, Increases Spatial Memory and Hippocampal Neuron Density Through the Improvement of Extracellular Signal Regulated Protein Kinase Expression, Cholinergic Function, and Oxidative Status in Ovariectomized Rats

2018 ◽  
Vol 21 (5) ◽  
pp. 431-441 ◽  
Author(s):  
Jintanaporn Wattanathorn ◽  
Woranan Kirisattayakul ◽  
Bhalang Suriharn ◽  
Kamol Lertrat
Keyword(s):  
Hippocampal Neuron ◽  
Oxidative Status ◽  
Ovariectomized Rats ◽  
The Novel ◽  
Cognitive Enhancer ◽  
Corn Cob ◽  
Neuron Density ◽  
Extracellular Signal ◽  
Functional Drink ◽  
Kinase Expression

scholarly journals Neuroprotective and Memory-Enhancing Effect of the Combined Extract of Purple Waxy Corn Cob and Pandan in Ovariectomized Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Woranan Kirisattayakul ◽  
Jintanaporn Wattanathorn ◽  
Sittichai Iamsaard ◽  
Jinatta Jittiwat ◽  
Bhalang Suriharn ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Object Recognition ◽  
Hormone Replacement ◽  
Ovariectomized Rats ◽  
Acetylcholinesterase Inhibition ◽  
Corn Cob ◽  
Neuron Density ◽  
Oxidative Stress Status ◽  
Waxy Corn ◽  
Memory Enhancing

The neuroprotectant and memory enhancer supplement for menopause is required due to the side effects of hormone replacement therapy. Since purple waxy corn cob and pandan leaves exert antioxidant and acetylcholinesterase inhibition (AChEI) effects, we hypothesized that the combined extract of both plants (PCP) might provide synergistic effect leading to the improved brain damage and memory impairment in experimental menopause. To test this hypothesis, female Wistar rats were ovariectomized bilaterally and orally given various doses of the functional drink at doses of 20, 40, and 80 mg/kg for 28 days. The animals were assessed nonspatial memory using object recognition test every 7 days throughout the study period. At the end of study, they were assessed with oxidative stress status, AChEI, neuron density, and ERK1/2 signal in the prefrontal cortex (PFC). Interestingly, all doses of PCP increased object recognition memory and neuron density but decreased oxidative stress status in PFC. Low dose of PCP also decreased AChE activity while medium dose of PCP increased phosphorylation of ERK1/2 in PFC. Therefore, the improved oxidative stress status and cholinergic function together with signal transduction via ERK in PFC might be responsible for the neuroprotective and memory-enhancing effects of PCP.

scholarly journals Memory-Enhancing Effect of a Phytosome Containing the Combined Extract of Mulberry Fruit and Ginger in an Animal Model of Ischemic Stroke with Metabolic Syndrome

2020 ◽  
Vol 2020 ◽  
pp. 1-19
Author(s):  
Jintanaporn Wattanathorn ◽  
Nut Palachai ◽  
Wipawee Thukham-mee ◽  
Supaporn Muchimapura
Keyword(s):  
Metabolic Syndrome ◽  
Ischemic Stroke ◽  
Erk Pathway ◽  
Enhancing Effect ◽  
Neuron Density ◽  
Mulberry Fruit ◽  
Extracellular Signal ◽  
Male Wistar Rats ◽  
Underlying Mechanisms ◽  
The Right

The prevalence of dementia following cerebral ischemia in metabolic syndrome (MetS) condition is increasing, and most of the cases are often severe. Unfortunately, no effective strategy for treating this condition is available. Based on the positive modulation effect of a polyphenol-rich substance on dementia and the improvement in bioavailability and stability of polyphenols induced by the phytosome technique together with the use of the synergistic concept, we hypothesized that a phytosome containing the combined extract of mulberry fruit and ginger (PMG) should mitigate dementia and memory impairment following ischemic stroke in MetS. MetS was induced in male Wistar rats weighing 180-200 g by exposure to a 16-week feeding period of high-carbohydrate high-fat (HCHF) diet. MetS rats were orally given PMG at doses of 50, 100, and 200 mg·kg-1 BW 21 days before and 21 days after the occlusion of the right middle cerebral artery (Rt. MCAO). Then, their spatial memory was determined and the possible underlying mechanisms explored via the alterations of acetylcholinesterase (AChE), neuron density, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), interleukin-6 (IL-6), and signal transduction via extracellular signal-regulated kinase (ERK) pathway in both the cerebral cortex and the hippocampus. It was found that PMG significantly enhanced memory. It also decreased AChE, IL-6, and MDA but increased SOD, CAT, GSH-Px, neuron density, and phosphorylation of ERK. These data suggested the cognitive enhancing effect of PMG. The possible underlying mechanisms might occur partly via the improvement of cholinergic function via the ERK pathway together with the decrease in neurodegeneration induced by the reduction of oxidative stress and inflammation. However, a subchronic toxicity study is also required to assure the safety of PMG consumption before moving forward to a clinical trial study.

Effects of the loss and reconstruction of molar occlusal support on memory retrieval and hippocampal neuron density in rats

2019 ◽  
Vol 63 (3) ◽  
pp. 283-287 ◽  
Author(s):  
Akimasa Kurozumi ◽  
Tetsuya Hara ◽  
Shunichi Sakamoto ◽  
Daisuke Araki ◽  
Sachiyo Iida-Tamada ◽  
...  
Keyword(s):  
Memory Retrieval ◽  
Hippocampal Neuron ◽  
Neuron Density
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