Reversal of Aged Muscle Stem Cell Dysfunction

2016 ◽  
Vol 19 (5) ◽  
pp. 423-429 ◽  
Author(s):  
James W. Larrick ◽  
Jasmine W. Larrick ◽  
Andrew R. Mendelsohn
Keyword(s):  
Stem Cell ◽  
Muscle Stem Cell ◽  
Cell Dysfunction

Myostatin is associated with age‐related human muscle stem cell dysfunction

2012 ◽  
Vol 26 (6) ◽  
pp. 2509-2521 ◽  
Author(s):  
Bryon R. McKay ◽  
Daniel I. Ogborn ◽  
Leeann M. Bellamy ◽  
Mark A. Tarnopolsky ◽  
Gianni Parise
Keyword(s):  
Stem Cell ◽  
Human Muscle ◽  
Muscle Stem Cell ◽  
Cell Dysfunction ◽  
Age Related

scholarly journals Muscle stem cell dysfunction impairs muscle regeneration in a mouse model of Down syndrome

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Bradley Pawlikowski ◽  
Nicole Dalla Betta ◽  
Tiffany Elston ◽  
Darian A. Williams ◽  
Bradley B. Olwin
Keyword(s):  
Down Syndrome ◽  
Stem Cell ◽  
Mouse Model ◽  
Muscle Regeneration ◽  
Muscle Stem Cell ◽  
Cell Dysfunction

scholarly journals Elevated SOCS3 and altered IL-6 signaling is associated with age-related human muscle stem cell dysfunction

2013 ◽  
Vol 304 (8) ◽  
pp. C717-C728 ◽  
Author(s):  
Bryon R. McKay ◽  
Daniel I. Ogborn ◽  
Jeff M. Baker ◽  
Kyle G. Toth ◽  
Mark A. Tarnopolsky ◽  
...  
Keyword(s):  
Stem Cell ◽  
Young Male ◽  
The Elderly ◽  
Knee Extension ◽  
Cytokine Signaling ◽  
Muscle Stem Cell ◽  
Adult Men ◽  
Cell Dysfunction ◽  
Age Related ◽  
Socs3 Protein

Aging is associated with increased circulating interleukin-6 (IL-6) and a reduced myogenic capacity, marked by reduced muscle stem cell [satellite cell (SC)] activity. Although IL-6 is important for normal SC function, it is unclear whether elevated IL-6 associated with aging alters SC function. We hypothesized that mild chronically elevated IL-6 would be associated with a blunted SC response through altered IL-6 signaling and elevated suppressor of cytokine signaling-3 (SOCS3) in the elderly. Nine healthy older adult men (OA; 69.6 ± 3.9 yr) and 9 young male controls (YC; 21. 3 ± 3.1 yr) completed 4 sets of 10 repetitions of unilateral leg press and knee extension (75% of 1-RM). Muscle biopsies and blood were obtained before and 3, 24, and 48 h after exercise. Basal SC number was 33% lower in OA vs. YC, and the response was blunted in OA. IL-6+/Pax7+ cells demonstrated a divergent response in OA, with YC increasing to 69% at 3 h and peaking at 24 h (72%), while IL-6+/Pax7+ cells were not increased until 48 h in OA (61%). Type II fiber-associated phosphorylated signal transducer and activator of transcription (pSTAT3)+/Pax7+ cells demonstrated a similar delay in OA, not increasing until 48 h (vs. 3 h in YC). SOCS3 protein was 86% higher in OA. These data demonstrate an age-related impairment in normal SC function that appears to be influenced by SOCS3 protein and delayed induction of IL-6 and pSTAT3 in the SCs of OA. Collectively, these data suggest dysregulated IL-6 signaling as a consequence of aging contributes to the blunted muscle stem cell response.

Sign in / Sign up

Export Citation Format

Share Document