Rapamycin As an Antiaging Therapeutic?: Targeting Mammalian Target of Rapamycin to Treat Hutchinson–Gilford Progeria and Neurodegenerative Diseases

Andrew R. Mendelsohn; James W. Larrick

doi:10.1089/rej.2011.1238

Rapamycin As an Antiaging Therapeutic?: Targeting Mammalian Target of Rapamycin to Treat Hutchinson–Gilford Progeria and Neurodegenerative Diseases

Rejuvenation Research ◽

10.1089/rej.2011.1238 ◽

2011 ◽

Vol 14 (4) ◽

pp. 437-441 ◽

Cited By ~ 29

Author(s):

Andrew R. Mendelsohn ◽

James W. Larrick

Keyword(s):

Neurodegenerative Diseases ◽

Mammalian Target Of Rapamycin ◽

Target Of Rapamycin ◽

Therapeutic Targeting

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Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin

Progress in Neurobiology ◽

10.1016/j.pneurobio.2012.08.001 ◽

2012 ◽

Vol 99 (2) ◽

pp. 128-148 ◽

Cited By ~ 55

Author(s):

Zhao Zhong Chong ◽

Yan Chen Shang ◽

Shaohui Wang ◽

Kenneth Maiese

Keyword(s):

Neurodegenerative Diseases ◽

Mammalian Target Of Rapamycin ◽

Target Of Rapamycin

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Critical analysis of the potential for therapeutic targeting of mammalian target of rapamycin (mTOR) in gastric cancer

Gastrointestinal Cancer Targets and Therapy ◽

10.2147/gictt.s44255 ◽

2014 ◽

pp. 39

Author(s):

Mikito Inokuchi ◽

Keiji Kato ◽

Kazuyuki Kojima ◽

Kenichi Sugihara

Keyword(s):

Gastric Cancer ◽

Critical Analysis ◽

Mammalian Target Of Rapamycin ◽

Target Of Rapamycin ◽

Therapeutic Targeting

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Conophylline Protects Cells in Cellular Models of Neurodegenerative Diseases by Inducing Mammalian Target of Rapamycin (mTOR)-independent Autophagy

Journal of Biological Chemistry ◽

10.1074/jbc.m114.606293 ◽

2015 ◽

Vol 290 (10) ◽

pp. 6168-6178 ◽

Cited By ~ 27

Author(s):

Yukiko Sasazawa ◽

Natsumi Sato ◽

Kazuo Umezawa ◽

Siro Simizu

Keyword(s):

Neurodegenerative Diseases ◽

Mammalian Target Of Rapamycin ◽

Target Of Rapamycin ◽

Cellular Models

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Faculty Opinions recommendation of Antagonistic roles for CTLA-4 and the mammalian target of rapamycin in the regulation of clonal anergy: enhanced cell cycle progression promotes recall antigen responsiveness.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1002644.29305 ◽

2001 ◽

Author(s):

Ron Schwartz

Keyword(s):

Cell Cycle ◽

Cell Cycle Progression ◽

Mammalian Target Of Rapamycin ◽

Target Of Rapamycin ◽

Cycle Progression ◽

Recall Antigen ◽

Clonal Anergy

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Faculty Opinions recommendation of Multiple site acetylation of Rictor stimulates mammalian target of rapamycin complex 2 (mTORC2)-dependent phosphorylation of Akt protein.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13420972.15108061 ◽

2012 ◽

Author(s):

Rony Seger ◽

Zhong Yao

Keyword(s):

Mammalian Target Of Rapamycin ◽

Target Of Rapamycin ◽

Multiple Site

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Faculty Opinions recommendation of The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.14253971.15768075 ◽

2012 ◽

Author(s):

Joseph Avruch ◽

Angela Papageorgiou

Keyword(s):

Gene Expression ◽

Mammalian Target Of Rapamycin ◽

Transcriptional Profile ◽

Target Of Rapamycin ◽

Biosynthetic Gene ◽

Biosynthetic Gene Expression

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Faculty Opinions recommendation of Loss of the repressor REST in uterine fibroids promotes aberrant G protein-coupled receptor 10 expression and activates mammalian target of rapamycin pathway.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717976173.793470470 ◽

2013 ◽

Author(s):

Phyllis Leppert

Keyword(s):

G Protein ◽

Mammalian Target Of Rapamycin ◽

Uterine Fibroids ◽

Target Of Rapamycin ◽

G Protein Coupled Receptor ◽

G Protein Coupled

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Faculty Opinions recommendation of Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717977210.793470744 ◽

2013 ◽

Author(s):

Matt Kaeberlein

Keyword(s):

Mammalian Target Of Rapamycin ◽

Target Of Rapamycin ◽

Cognitive Components ◽

Components Of Behavior

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Faculty Opinions recommendation of Response of lymphangioleiomyomatosis to a mammalian target of rapamycin inhibitor (temsirolimus) -based treatment.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725237527.793501496 ◽

2014 ◽

Author(s):

Angelo Taveira-DaSilva

Keyword(s):

Mammalian Target Of Rapamycin ◽

Target Of Rapamycin

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Expression of phosphorylated mammalian target of rapamycin in colorectal cancer and its significance

Academic Journal of Second Military Medical University ◽

10.3724/sp.j.1008.2009.00517 ◽

2009 ◽

Vol 29 (5) ◽

pp. 517-520

Author(s):

Hong-gang XIANG ◽

Zhi-qian HU ◽

Wei-jun WANG ◽

Jian XU ◽

Jian ZHANG ◽

...

Keyword(s):

Colorectal Cancer ◽

Mammalian Target Of Rapamycin ◽

Target Of Rapamycin

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