Current Considerations for Low-Level Laser Therapy/Photobiomodulation Therapy in the Management of Side Effects of Chemoradiation Therapy for Cancer

2017 ◽  
Vol 35 (9) ◽  
pp. 457-458
Author(s):  
Kenji Yoshida
2018 ◽  
Vol 9 (3) ◽  
pp. 207-211
Author(s):  
Roya Safdari ◽  
Narges Pouremadi ◽  
Ehsan Talebzadeh ◽  
Arash Mottaghi ◽  
Shahram Amini ◽  
...  

2017 ◽  
Vol 20 (2) ◽  
pp. 117-122 ◽  
Author(s):  
Wilfredo Alejandro González-Arriagada ◽  
Lara Maria Alencar Ramos ◽  
Marco Aurélio Carvalho Andrade ◽  
Marcio Ajudarte Lopes

2021 ◽  
Vol 17 (2) ◽  
pp. 33-46
Author(s):  
Guilherme Henrique Salarolli ◽  
Kiani dos Santos de Paula ◽  
Sara Bacelar Miranda ◽  
Lucas Fernandes Leal

Cancer is a genetic disease, and one of the main public health problems. Cancer treatments (chemotherapy and radiotherapy) have some side effects, such as mucositis, which is the inflammation of the oral mucosa, and which generates a series of discomforts, sometimes milder, sometimes more severe. One of the treatments indicated for mucositis is low-level laser therapy, which acts to reduce symptoms. The purpose of this article is to describe four protocols of laser therapy, which were applied at Hospital Santa Rita de Cássia — Vitória, and also to discuss the results that were satisfactory.


2020 ◽  
Vol 15 (5) ◽  
pp. 400-413 ◽  
Author(s):  
Khatereh Khorsandi ◽  
Reza Hosseinzadeh ◽  
Heidi Abrahamse ◽  
Reza Fekrazad

Background: Stem cells have attracted the researchers interest, due to their applications in regenerative medicine. Their self-renewal capacity for multipotent differentiation, and immunomodulatory properties make them unique to significantly contribute to tissue repair and regeneration applications. Recently, stem cells have shown increased proliferation when irradiated with low-level laser therapy or Photobiomodulation Therapy (PBMT), which induces the activation of intracellular and extracellular chromophores and the initiation of cellular signaling. The purpose of this study was to evaluate this phenomenon in the literature. Methods: The literature investigated the articles written in English in four electronic databases of PubMed, Scopus, Google Scholar and Cochrane up to April 2019. Stem cell was searched by combining the search keyword of "low-level laser therapy" OR "low power laser therapy" OR "low-intensity laser therapy" OR "photobiomodulation therapy" OR "photo biostimulation therapy" OR "LED". In total, 46 articles were eligible for evaluation. Results: Studies demonstrated that red to near-infrared light is absorbed by the mitochondrial respiratory chain. Mitochondria are significant sources of reactive oxygen species (ROS). Mitochondria play an important role in metabolism, energy generation, and are also involved in mediating the effects induced by PBMT. PBMT may result in the increased production of (ROS), nitric oxide (NO), adenosine triphosphate (ATP), and cyclic adenosine monophosphate (cAMP). These changes, in turn, initiate cell proliferation and induce the signal cascade effect. Conclusion: The findings of this review suggest that PBMT-based regenerative medicine could be a useful tool for future advances in tissue engineering and cell therapy.


Materials ◽  
2019 ◽  
Vol 12 (24) ◽  
pp. 4051 ◽  
Author(s):  
Marcelie Priscila de Oliveira Rosso ◽  
Daniela Vieira Buchaim ◽  
Karina Torres Pomini ◽  
Bruna Botteon Della Coletta ◽  
Carlos Henrique Bertoni Reis ◽  
...  

The use of low-level laser therapy (LLLT) with biomodulatory effects on biological tissues, currently called photobiomodulation therapy (PBMT), assists in healing and reduces inflammation. The application of biomaterials has emerged in bone reconstructive surgery, especially the use of bovine bone due to its biocompatibility. Due to the many benefits related to the use of PBMT and bovine bones, the aim of this research was to review the literature to verify the relationship between PBMT and the application of bovine bone in bone reconstruction surgeries. We chose the PubMed/MEDLINE, Web of Science, and Scopus databases for the search by matching the keywords: “Bovine bone AND low-level laser therapy”, “Bovine bone AND photobiomodulation therapy”, “Xenograft AND low-level laser therapy”, and “Xenograft AND photobiomodulation therapy”. The initial search of the three databases retrieved 240 articles, 18 of which met all inclusion criteria. In the studies concerning animals (17 in total), there was evidence of PBMT assisting in biomaterial-related conduction, formation of new bone, bone healing, immunomarker expression, increasing collagen fibers, and local inflammation reduction. However, the results disagreed with regard to the resorption of biomaterial particles. The only human study showed that PBMT with bovine bone was effective for periodontal regeneration. It was concluded that PBMT assists the process in bone reconstruction when associated with bovine bone, despite divergences between applied protocols.


2021 ◽  
Vol 10 (1) ◽  
pp. e59410112072
Author(s):  
Yuri Victor Barbosa Silva ◽  
Thiago Correia da Silva Rezzo ◽  
Carla Roberta Tim ◽  
Patrícia Gabrielli Vassão ◽  
Thalita Páez ◽  
...  

A osteoartrite do joelho (OAJ) é uma das doenças articulares degenerativa progressiva mais comuns em todo o mundo e também uma das principais causas de incapacidade e danos à qualidade de vida. A terapia de fotobiomodulação (PBMT, do inglês Photobiomodulation Therapy) através de laser de baixa intensidade (LLLT, do inglês Low Level Laser Therapy) tem mostrado ser um tratamento promissora e com bons resultados para diversas doenças crônicas, incluindo as alterações que acometem o sistema articular. Dentro deste contexto, o objetivo deste estudo é proporcionar, por meio de uma revisão narrativa, uma compreensão das evidências atuais disponíveis sobre o mecanismo de ação e importância clínica da PBMT a laser no tratamento da OAJ. As buscas foram realizadas nas bases de dados bibliográficas do PubMed/MEDLINE, Biblioteca virtual da saúde (BVS), Web of Science e SciELO. Com base nos estudos revisados ​​por pares, os dados laboratoriais em modelos animais experimentais e estudos clínicos mostram que a PBM é capaz de reduzir a morte de condrócitos, estimular a síntese de componentes da matriz extracelular (MEC), atenuar a liberação de mediadores inflamatórios e proteolíticos presente em doenças articulares crônicas, prevenindo assim a degradação do tecido articular e periarticulares. Consequentemente, clinicamente, pode ser observado melhora da dor, funcionalidade e qualidade de vida do indivíduo acometido com OAJ e tratados com a PBMT a laser. Assim, podemos concluir que a PBMT a laser pode constituir um excelente coadjuvante no tratamento da OAJ, uma vez que é um método não invasivo e também apresenta custos relativamente baixos.


BMC Cancer ◽  
2017 ◽  
Vol 17 (1) ◽  
Author(s):  
G. David Baxter ◽  
Lizhou Liu ◽  
Simone Petrich ◽  
Angela Spontelli Gisselman ◽  
Cathy Chapple ◽  
...  

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