scholarly journals Consensus Genome-Wide Expression Quantitative Trait Loci and Their Relationship with Human Complex Trait Disease

2016 ◽  
Vol 20 (7) ◽  
pp. 400-414 ◽  
Author(s):  
Chen-Hsin Yu ◽  
Lipika R. Pal ◽  
John Moult
Keyword(s):  
Quantitative Trait Loci ◽  
Quantitative Trait ◽  
Complex Trait ◽  
Expression Quantitative Trait Loci ◽  
Genome Wide ◽  
Trait Loci ◽  
Human Complex Trait ◽  
Genome Wide Expression ◽  
Human Complex

scholarly journals Genome-wide expression quantitative trait loci (eQTL) analysis in maize

BMC Genomics ◽  
2011 ◽  
Vol 12 (1) ◽  
Author(s):  
Beth Holloway ◽  
Stanley Luck ◽  
Mary Beatty ◽  
J-Antoni Rafalski ◽  
Bailin Li
Keyword(s):  
Quantitative Trait Loci ◽  
Quantitative Trait ◽  
Eqtl Analysis ◽  
Expression Quantitative Trait Loci ◽  
Genome Wide ◽  
Trait Loci ◽  
Genome Wide Expression

scholarly journals Genome-Wide Haplotype Analysis of Cis Expression Quantitative Trait Loci in Monocytes

PLoS Genetics ◽  
2013 ◽  
Vol 9 (1) ◽  
pp. e1003240 ◽  
Author(s):  
Sophie Garnier ◽  
Vinh Truong ◽  
Jessy Brocheton ◽  
Tanja Zeller ◽  
Maxime Rovital ◽  
...  
Keyword(s):  
Quantitative Trait Loci ◽  
Quantitative Trait ◽  
Haplotype Analysis ◽  
Expression Quantitative Trait Loci ◽  
Genome Wide ◽  
Trait Loci

scholarly journals Characterization of expression quantitative trait loci in extensively phenotyped pedigrees ascertained for bipolar disorder

2015 ◽  
Author(s):  
Christine Peterson ◽  
Susan Service ◽  
Anna Jasinska ◽  
Fuying Gao ◽  
Ivette Zelaya ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bipolar Disorder ◽  
Quantitative Trait Loci ◽  
Quantitative Trait ◽  
Complex Traits ◽  
Expression Quantitative Trait Loci ◽  
Genome Wide ◽  
Wide Range ◽  
Trait Loci

The observation that variants regulating gene expression (expression quantitative trait loci, eQTL) are at a high frequency among SNPs associated with complex traits has made the genome-wide characterization of gene expression an important tool in genetic mapping studies of such traits. As part of a study to identify genetic loci contributing to bipolar disorder and a wide range of BP-related quantitative traits in members of 26 pedigrees from Costa Rica and Colombia, we measured gene expression in lymphoblastoid cell lines derived from 786 pedigree members. The study design enabled us to comprehensively reconstruct the genetic regulatory network in these families, provide estimates of heritability, identify eQTL, evaluate missing heritability for the eQTL, and quantify the number of different alleles contributing to any given locus.

scholarly journals Integrated Genome-Wide Analysis of MicroRNA Expression Quantitative Trait Loci in Pig Longissimus Dorsi Muscle

2021 ◽  
Vol 12 ◽  
Author(s):  
Kaitlyn R. Daza ◽  
Deborah Velez-Irizarry ◽  
Sebastian Casiró ◽  
Juan P. Steibel ◽  
Nancy E. Raney ◽  
...  
Keyword(s):  
Gene Expression ◽  
Quantitative Trait Loci ◽  
Mirna Expression ◽  
Quantitative Trait ◽  
Complex Traits ◽  
Carcass Composition ◽  
Longissimus Dorsi ◽  
Expression Quantitative Trait Loci ◽  
Genome Wide ◽  
Trait Loci

Determining mechanisms regulating complex traits in pigs is essential to improve the production efficiency of this globally important protein source. MicroRNAs (miRNAs) are a class of non-coding RNAs known to post-transcriptionally regulate gene expression affecting numerous phenotypes, including those important to the pig industry. To facilitate a more comprehensive understanding of the regulatory mechanisms controlling growth, carcass composition, and meat quality phenotypes in pigs, we integrated miRNA and gene expression data from longissimus dorsi muscle samples with genotypic and phenotypic data from the same animals. We identified 23 miRNA expression Quantitative Trait Loci (miR-eQTL) at the genome-wide level and examined their potential effects on these important production phenotypes through miRNA target prediction, correlation, and colocalization analyses. One miR-eQTL miRNA, miR-874, has target genes that colocalize with phenotypic QTL for 12 production traits across the genome including backfat thickness, dressing percentage, muscle pH at 24 h post-mortem, and cook yield. The results of our study reveal genomic regions underlying variation in miRNA expression and identify miRNAs and genes for future validation of their regulatory effects on traits of economic importance to the global pig industry.

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