scholarly journals Structural Insights on the Potential Significance of the Twin Asn-Residue Found at the Base of the Hemagglutinin 2 Stalk in All Influenza A H1N1 Strains: A Computational Study with Clinical Implications

2013 ◽  
Vol 17 (6) ◽  
pp. 297-301 ◽  
Author(s):  
Marni E. Cueno ◽  
Kenichi Imai ◽  
Kuniyasu Ochiai
Keyword(s):  
Influenza A ◽  
Computational Study ◽  
Clinical Implications ◽  
Potential Significance ◽  
Influenza A H1n1 ◽  
Structural Insights

scholarly journals Influenza co-infection associated with severity and mortality in COVID-19 patients

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Bandar Alosaimi ◽  
Asif Naeem ◽  
Maaweya E. Hamed ◽  
Haitham S. Alkadi ◽  
Thamer Alanazi ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Influenza A ◽  
Direct Relationship ◽  
Chlamydia Pneumoniae ◽  
Human Adenovirus ◽  
Clinical Implications ◽  
Respiratory Pathogens ◽  
Flu Vaccination ◽  
Influenza A H1n1 ◽  
High Prevalence

Abstract Background In COVID-19 patients, undetected co-infections may have severe clinical implications associated with increased hospitalization, varied treatment approaches and mortality. Therefore, we investigated the implications of viral and bacterial co-infection in COVID-19 clinical outcomes. Methods Nasopharyngeal samples were obtained from 48 COVID-19 patients (29% ICU and 71% non-ICU) and screened for the presence of 24 respiratory pathogens using six multiplex PCR panels. Results We found evidence of co-infection in 34 COVID-19 patients (71%). Influenza A H1N1 (n = 17), Chlamydia pneumoniae (n = 13) and human adenovirus (n = 10) were the most commonly detected pathogens. Viral co-infection was associated with increased ICU admission (r = 0.1) and higher mortality (OR 1.78, CI = 0.38–8.28) compared to bacterial co-infections (OR 0.44, CI = 0.08–2.45). Two thirds of COVID-19 critically ill patients who died, had a co-infection; and Influenza A H1N1 was the only pathogen for which a direct relationship with mortality was seen (r = 0.2). Conclusions Our study highlights the importance of screening for co-infecting viruses in COVID-19 patients, that could be the leading cause of disease severity and death. Given the high prevalence of Influenza co-infection in our study, increased coverage of flu vaccination is encouraged to mitigate the transmission of influenza virus during the on-going COVID-19 pandemic and reduce the risk of severe outcome and mortality.

Nachweis bakterieller Superinfektionen bei Patienten mit Influenza A H1N1 mithilfe kultur-unabhängiger molekulargenetischer Typisierung

2010 ◽  
Vol 222 (S 01) ◽  
Author(s):  
M Schiller ◽  
S Eva ◽  
A Halfmann ◽  
HJ Schäfers ◽  
B Gärtner ◽  
...  
Keyword(s):  
Influenza A ◽  
Influenza A H1n1

Narkolepsie nach Impfung gegen die pandemische Influenza A/H1N1/v?

Schlaf ◽  
2013 ◽  
Vol 2 (03) ◽  
pp. 154-160
Author(s):  
Geert Mayer ◽  
Brigitte Keller-Stanislawski ◽  
Doris Oberle
Keyword(s):  
Influenza A ◽  
Influenza A H1n1

Im Herbst/Winter 2009/2010 wurden etwa 30,8 Mio. Menschen in der Europäischen Union mit Pandemrix® gegen die pandemische Influenza A/H1N1/v geimpft. Der von GlaxoSmithKline produzierte Impfstoff war im September 2009 von der Europäischen Kommission als Pandemieimpfstoff zugelassen worden. Im Sommer 2010 wurde erstmals über Fälle einer Narkolepsie bei Kindern und Jugendlichen nach Impfung mit Pandemrix® in Schweden und Finnland berichtet.

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