scholarly journals Persons with Chronic Spinal Cord Injury Have Decreased Natural Killer Cell and Increased Toll-Like Receptor/Inflammatory Gene Expression

2018 ◽  
Vol 35 (15) ◽  
pp. 1819-1829 ◽  
Author(s):  
Paige Herman ◽  
Adam Stein ◽  
Katie Gibbs ◽  
Ilya Korsunsky ◽  
Peter Gregersen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Natural Killer Cell ◽  
Natural Killer ◽  
Killer Cell ◽  
Toll Like Receptor ◽  
Chronic Spinal Cord Injury ◽  
Inflammatory Gene Expression ◽  
Cord Injury

scholarly journals Characterization of inflammatory gene expression and galectin-3 function after spinal cord injury in mice

2012 ◽  
Vol 1475 ◽  
pp. 96-105 ◽  
Author(s):  
Ahdeah Pajoohesh-Ganji ◽  
Susan M. Knoblach ◽  
Alan I. Faden ◽  
Kimberly R. Byrnes
Keyword(s):  
Gene Expression ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Inflammatory Gene Expression ◽  
Inflammatory Gene ◽  
Cord Injury ◽  
Galectin 3

scholarly journals Combinatorial small molecule-mediated activation of CBP/p300 with environmental enrichment in chronic severe experimental spinal cord injury to enable axon regeneration and sprouting for functional recovery

2021 ◽  
Author(s):  
Franziska Mueller ◽  
Francesco De Virgiliis ◽  
Guiping Kong ◽  
Luming Zhou ◽  
Elisabeth Serger ◽  
...  
Keyword(s):  
Gene Expression ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Synaptic Plasticity ◽  
Small Molecule ◽  
Functional Recovery ◽  
Neural Activity ◽  
Environmental Enrichment ◽  
Chronic Spinal Cord Injury ◽  
Cord Injury

The interruption of spinal circuitry following spinal cord injury disrupts neural activity and is followed by a failure to mount an effective regenerative gene expression response resulting in permanent neurological disability. Functional recovery requires the enhancement of axonal and synaptic plasticity of spared as well as injured fibres, which need to sprout and/or regenerate to form new connections. Here we will investigate whether the combined epigenetic stimulation of the regenerative gene expression program with neuronal activity-dependent enhancement of neuroplasticity and guidance can overcome the current inability to promote neurological recovery in severe and chronic spinal cord injury. This will be carried out by delivering the small molecule CBP/p300 activator CSP-TTK21 in combination with environmental enrichment. We will deliver the CBP/p300 activator CSP-TTK21 weekly between week twelve and twenty following a severe transection model of spinal cord injury in the mouse. Data analysis will assess modifications in regenerative signalling, in motor and sensory axon sprouting and regeneration, in synaptic plasticity as well as in neurological sensorimotor recovery. This approach will advance our mechanistic understanding of regenerative failure and provide insight of whether combining growth promoting strategies with enhancement of neural activity is an effective therapeutic strategy in chronic spinal cord injury.

The Severity of Spinal Cord Injury Determines the Inflammatory Gene Expression Pattern after Immunization with Neural-Derived Peptides

2018 ◽  
Vol 65 (2) ◽  
pp. 190-195 ◽  
Author(s):  
Elisa García ◽  
Raúl Silva-García ◽  
Adrian Flores-Romero ◽  
Liliana Blancas-Espinoza ◽  
Roxana Rodríguez-Barrera ◽  
...  
Keyword(s):  
Gene Expression ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Expression Pattern ◽  
Gene Expression Pattern ◽  
Inflammatory Gene Expression ◽  
Inflammatory Gene ◽  
Cord Injury

Upregulation of Kv 1.4 protein and gene expression after chronic spinal cord injury

2002 ◽  
Vol 443 (2) ◽  
pp. 154-167 ◽  
Author(s):  
Lori Edwards ◽  
Raad Nashmi ◽  
Owen Jones ◽  
Peter Backx ◽  
Cameron Ackerley ◽  
...  
Keyword(s):  
Gene Expression ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Chronic Spinal Cord Injury ◽  
Cord Injury

233-LB: Spinal Cord Injury Inhibited-FGF21 Signaling Is Associated with Dysregulation of Metabolic Gene Expression in Mouse Liver and Adipose Tissue

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 233-LB
Author(s):  
XIN-HUA LIU ◽  
LAUREN HARLOW ◽  
ZACHARY GRAHAM ◽  
JOSHUA F. YARROW ◽  
KENNETH CUSI ◽  
...  
Keyword(s):  
Gene Expression ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Adipose Tissue ◽  
Mouse Liver ◽  
Metabolic Gene ◽  
Metabolic Gene Expression ◽  
Cord Injury
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