scholarly journals Hyperbaric Oxygen Therapy in the Treatment of Acute Severe Traumatic Brain Injury: A Systematic Review

2018 ◽  
Vol 35 (4) ◽  
pp. 623-629 ◽  
Author(s):  
Samuel Daly ◽  
Maxwell Thorpe ◽  
Sarah Rockswold ◽  
Molly Hubbard ◽  
Thomas Bergman ◽  
...  
Keyword(s):  
Systematic Review ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Hyperbaric Oxygen ◽  
Severe Traumatic Brain Injury ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy

scholarly journals Hyperbaric oxygen for severe traumatic brain injury: a randomized trial

2020 ◽  
Vol 48 (10) ◽  
pp. 030006052093982
Author(s):  
Xianliang Zhong ◽  
Aijun Shan ◽  
Jianzhong Xu ◽  
Jian Liang ◽  
Ying Long ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Hyperbaric Oxygen ◽  
Severe Traumatic Brain Injury ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Vital Signs ◽  
Neurological Function ◽  
Control Group ◽  
Experimental Group

Objective The present study aimed to explore the effects of hyperbaric oxygen therapy on the prognosis and neurological function of patients with severe traumatic brain injury. Methods A prospective study was carried out in 88 patients diagnosed with severe brain injury at our hospital and they were enrolled as research participants and randomly assigned to control and experimental groups (n = 44 per group) using a random number table method. Both groups underwent routine treatment. Patients in the experimental group were administered hyperbaric oxygen therapy approximately 1 week after admission when their vital signs had stabilized. Results No significant intergroup differences were observed in the Glasgow Coma Scale (GCS) and U.S. National Institutes of Health Stroke Scale (NIHSS) scores before treatment. However, after oxygen treatment, compared with the control group, the experimental group showed higher GCS and lower NIHSS scores. The GCS score at admission, tracheotomy status, and first hyperbaric oxygen therapy duration were independent prognostic factors in patients with severe traumatic brain injury. Conclusion Hyperbaric oxygen therapy may promote recovery of neurological function and improve the cognitive function and prognosis of patients with severe traumatic brain injury.

Evaluation of the hyperbaric oxygen therapy on the flash visual evoked potential P2 in patients with severe traumatic brain injury

2021 ◽  
pp. 1-4
Author(s):  
Lei Duan ◽  
Changbao Wang ◽  
Xia Wang ◽  
Aiping Wang ◽  
Tingting Xu ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Hyperbaric Oxygen ◽  
Severe Traumatic Brain Injury ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Evoked Potential ◽  
Extraction Rate ◽  
Flash Visual Evoked Potential ◽  
Visual Evoked

BACKGROUND: Studies have shown that hyperbaric oxygen therapy (HBOT) can improve the extraction rate and latency of cortical evoked potential N20 in patients with severe traumatic brain injury, but there are only a few studies on the effect of flash visual evoked potential. OBJECTIVE: This study investigated the effect of hyperbaric oxygen therapy on the P2 wave of flash visual evoked potentials in patients with severe traumatic brain injury. METHODS: In total, we examined 40 TBI patients who received HBOT, in combination with medication, and 38 TBI patients who received medication alone. The FVEPs apparatus was used to detect the P2 wave extraction rate and the latency of the elicited waveform before and after treatment in both the medicated-only controls and HBOT-treated cohorts. RESULTS: Compared with the control group, the HBOT treatment group showed a higher P2 wave elicitation rate, and the P2 wave latency of the HBOT treatment group was significantly shortened (p <  0.05, all). CONCLUSIONS: HBOT, in combination with drug therapy, can significantly increase the P2 wave extraction rate and shorten P2 latency in patients with TBI.

A Clinical Study on Hyperbaric Oxygen Therapy to Treat Severe Traumatic Brain Injury Traumatic Brain Injury

2020 ◽  
Author(s):  
lin zhu ◽  
Wen Shi Guo ◽  
Juan Lu
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Scale Score ◽  
Hyperbaric Oxygen ◽  
Severe Traumatic Brain Injury ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Intracerebral Hematoma ◽  
Control Group ◽  
Observation Group

Abstract This clinical research initiates to study the early hyperbaric oxygen therapy applied in Severe Traumatic Brain Injury based on lots of clinical treatment practice for the Severe Craniocerebral Injury patients, whose survival and rehabilitation has drawn great attention among neurosurgeon experts.Background: 1. To investigate the clinical effect of early stage hyperbaric oxygen therapy in the treatment of severe traumatic brain injury; 2. To study the treatment therapy of when to apply hyperbaric oxygen therapy to Severe Craniocerebral Injury patients; 3. To study if combining removal of intracerebral hematoma and craniotomy decompression with early stage hyperbaric oxygen therapy can achieve more effective treatment results.Methodology: 90 cases of severe craniocerebral injury patients admitted to neurosurgery department of 3201 hospital affiliated of Xi’an Jiaotong university were randomly divided into observation group and control group from January 2016 to January 2017, craniotomy for decompression and removal of intracerebral hematoma were performed in both groups. Hyperbaric oxygen therapy was started in the early postoperative period in the observation group and in the late postoperative period in the control group. The Glasgow Coma Scale Score (GCS) of the two groups were compared before and after operation. Patients were followed up for 6 months, the clinical prognosis was assessed by the Glasgow Outcome Scale Score (GOS) and long-term Karnofsky Performance Status Score (KPS). Results: After treatment, GCS (Glasgow Coma Scale Score) scores of observation group was significantly higher than that of control group (P<O.05); After 6 months’ follow-up, the GOS (Glasgow Outcome Scale score) scores of observation group was significantly higher than that of control group (P<0.05), the favorable prognosis rate was significantly higher than that of the control group (P<0.05). The KPS (Karnofsky Performance Status Score) scores of the observation group were significantly better than that of the control group, and the difference was statistically significant (P < 0.05).Conclusion: Combing craniotomy decompression and removal of intracerebral hematoma with early hyperbaric oxygen-assisted therapy can significantly improve the survival rate, recovery rate and clinical prognosis of patients with severe traumatic brain injury.

scholarly journals Effect Sizes for Symptomatic and Cognitive Improvements in Traumatic Brain Injury Following Hyperbaric Oxygen Therapy

2021 ◽  
Author(s):  
Adam Thomas Biggs ◽  
Hugh M. Dainer ◽  
Lanny F Littlejohn
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Brain Injuries ◽  
Statistical Significance ◽  
Traumatic Brain Injuries ◽  
Therapeutic Benefit ◽  
Effect Sizes

Hyperbaric oxygen therapy has been proposed as a method to treat traumatic brain injuries. The combination of pressure and increased oxygen concentration produces a higher content of dissolved oxygen in the bloodstream, which could generate a therapeutic benefit for brain injuries. This dissolved oxygen penetrates deeper into damaged brain tissue than otherwise possible and promotes healing. The result includes improved cognitive functioning and an alleviation of symptoms. However, randomized controlled trials have failed to produce consistent conclusions across multiple studies. There are numerous explanations that might account for the mixed evidence, although one possibility is that prior evidence focuses primarily on statistical significance. The current analyses explored existing evidence by calculating an effect size from each active treatment group and each control group among previous studies. An effect size measure offers several advantages when comparing across studies as it can be used to directly contrast evidence from different scales, and it provides a proximal measure of clinical significance. When exploring the therapeutic benefit through effect sizes, there was a robust and consistent benefit to individuals who underwent hyperbaric oxygen therapy. Placebo effects from the control condition could account for approximately one-third of the observed benefits, but there appeared to be a clinically significant benefit to using hyperbaric oxygen therapy as a treatment intervention for traumatic brain injuries. This evidence highlights the need for design improvements when exploring interventions for traumatic brain injury as well as the importance of focusing on clinical significance in addition to statistical significance.

Effects of Hyperbaric Oxygen Therapy on Inflammasome Signaling after Traumatic Brain Injury

2016 ◽  
Vol 23 (2) ◽  
pp. 122-129 ◽  
Author(s):  
Fengyang Geng ◽  
Yinghua Ma ◽  
Tao Xing ◽  
Xianbo Zhuang ◽  
Jianxin Zhu ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy
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