scholarly journals Effects of Veliparib on Microglial Activation and Functional Outcomes after Traumatic Brain Injury in the Rat and Pig

2018 ◽  
Vol 35 (7) ◽  
pp. 918-929 ◽  
Author(s):  
Karen-Amanda Irvine ◽  
Robin K. Bishop ◽  
Seok Joon Won ◽  
Jianguo Xu ◽  
Katherine A. Hamel ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Functional Outcomes ◽  
Microglial Activation

scholarly journals Microglia: A Potential Drug Target for Traumatic Axonal Injury

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Xin Huang ◽  
Wendong You ◽  
Yuanrun Zhu ◽  
Kangli Xu ◽  
Xiaofeng Yang ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Drug Target ◽  
Microglial Activation ◽  
Axonal Injury ◽  
Traumatic Axonal Injury ◽  
Potential Drug Target ◽  
Potential Drug ◽  
Microglial Phenotype ◽  
M2 Phenotype

Traumatic axonal injury (TAI) is a major cause of death and disability among patients with severe traumatic brain injury (TBI); however, no effective therapies have been developed to treat this disorder. Neuroinflammation accompanying microglial activation after TBI is likely to be an important factor in TAI. In this review, we summarize the current research in this field, and recent studies suggest that microglial activation plays an important role in TAI development. We discuss several drugs and therapies that may aid TAI recovery by modulating the microglial phenotype following TBI. Based on the findings of recent studies, we conclude that the promotion of active microglia to the M2 phenotype is a potential drug target for the treatment of TAI.

scholarly journals Neuroglobin Genetic Polymorphisms and Their Relationship to Functional Outcomes after Traumatic Brain Injury

2010 ◽  
Vol 27 (6) ◽  
pp. 999-1006 ◽  
Author(s):  
Pei-Ying Chuang ◽  
Yvette P. Conley ◽  
Samuel M. Poloyac ◽  
David O. Okonkwo ◽  
Dianxu Ren ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Genetic Polymorphisms ◽  
Functional Outcomes
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