Functional Outcome Prediction after Traumatic Spinal Cord Injury Based on Acute Clinical Factors

2017 ◽  
Vol 34 (12) ◽  
pp. 2027-2033 ◽  
Author(s):  
Ludovic Kaminski ◽  
Virginie Cordemans ◽  
Eduard Cernat ◽  
Kouamé Innocent M'Bra ◽  
Jean-Marc Mac-Thiong
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Outcome ◽  
Outcome Prediction ◽  
Traumatic Spinal Cord Injury ◽  
Clinical Factors ◽  
Cord Injury

scholarly journals A Clinical Prediction Model for Long-Term Functional Outcome after Traumatic Spinal Cord Injury Based on Acute Clinical and Imaging Factors

2012 ◽  
Vol 29 (13) ◽  
pp. 2263-2271 ◽  
Author(s):  
Jefferson R. Wilson ◽  
Robert G. Grossman ◽  
Ralph F. Frankowski ◽  
Alexander Kiss ◽  
Aileen M. Davis ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Prediction Model ◽  
Functional Outcome ◽  
Traumatic Spinal Cord Injury ◽  
Clinical Prediction ◽  
Clinical Prediction Model ◽  
Cord Injury

A prediction model of functional outcome at 6 months using clinical findings of a person with traumatic spinal cord injury at 1 month after injury

Spinal Cord ◽  
2020 ◽  
Vol 58 (11) ◽  
pp. 1158-1165
Author(s):  
Yuto Ariji ◽  
Tetsuo Hayashi ◽  
Ryosuke Ideta ◽  
Ryuichiro Koga ◽  
Satoshi Murai ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Prediction Model ◽  
Functional Outcome ◽  
Clinical Findings ◽  
Traumatic Spinal Cord Injury ◽  
Cord Injury

scholarly journals Effects of Growth Hormone Treatment and Rehabilitation in Incomplete Chronic Traumatic Spinal Cord Injury: Insight from Proteome Analysis

2020 ◽  
Vol 10 (4) ◽  
pp. 183
Author(s):  
Tatiana Martin-Rojas ◽  
Tamara Sastre-Oliva ◽  
Ana Esclarín-Ruz ◽  
Felix Gil-Dones ◽  
Laura Mourino-Alvarez ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Growth Hormone ◽  
Spinal Cord Injury ◽  
Functional Outcome ◽  
Combined Treatment ◽  
Traumatic Spinal Cord Injury ◽  
Motor Score ◽  
Gh Treatment ◽  
Rehabilitation Treatment ◽  
Cord Injury

Despite promising advances in the medical management of spinal cord injury (SCI), there is still no available effective therapy to repair the neurological damage in patients who experience this life-transforming condition. Recently, we performed a phase II/III placebo-controlled randomized trial of safety and efficacy of growth hormone (GH) treatment in incomplete chronic traumatic spinal cord injury. The main findings were that the combined treatment of GH plus rehabilitation treatment is feasible and safe, and that GH but not placebo slightly improves the SCI individual motor score. Moreover, we found that an intensive and long-lasting rehabilitation program per se increases the functional outcome of SCI individuals. To understand the possible mechanisms of the improvement due to GH treatment (motor score) and due to rehabilitation (functional outcome), we used a proteomic approach. Here, we used a multiple proteomic strategy to search for recovery biomarkers in blood plasma with the potential to predict response to somatropin treatment and to delayed intensive rehabilitation. Forty-six patients were recruited and followed for a minimum period of 1 year. Patients were classified into two groups based on their treatment: recombinant somatropin (0.4 mg) or placebo. Both groups received rehabilitation treatment. Our strategy allowed us to perform one of the deepest plasma proteomic analyses thus far, which revealed two proteomic signatures with predictive value: (i) response to recombinant somatropin treatment and (ii) response to rehabilitation. The proteins implicated in these signatures are related to homeostasis, inflammation, and coagulation functions. These findings open novel possibilities to assess and therapeutically manage patients with SCI, which could have a positive impact on their clinical response.

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