scholarly journals Systemic Administration of Connexin43 Mimetic Peptide Improves Functional Recovery after Traumatic Spinal Cord Injury in Adult Rats

2017 ◽  
Vol 34 (3) ◽  
pp. 707-719 ◽  
Author(s):  
Yilin Mao ◽  
Ryan S. Tonkin ◽  
Tara Nguyen ◽  
Simon J. O'Carroll ◽  
Louise F. B. Nicholson ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Systemic Administration ◽  
Traumatic Spinal Cord Injury ◽  
Adult Rats ◽  
Mimetic Peptide ◽  
Cord Injury

scholarly journals Systemic Administration of Fibroblast Growth Factor 21 Improves the Recovery of Spinal Cord Injury (SCI) in Rats and Attenuates SCI-Induced Autophagy

2021 ◽  
Vol 11 ◽  
Author(s):  
Sipin Zhu ◽  
Yibo Ying ◽  
Lin Ye ◽  
Weiyang Ying ◽  
Jiahui Ye ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Functional Recovery ◽  
Nerve Cells ◽  
Systemic Administration ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Cord Injury

Protecting the death of nerve cells is an essential tactic for spinal cord injury (SCI) repair. Recent studies show that nerve growth factors can reduce the death of nerve cells and promote the healing of nerve injury. To investigate the conducive effect of fibroblast growth factor 21 (FGF21) on SCI repair. FGF21 proteins were systemically delivered into rat model of SCI via tail vein injection. We found that administration of FGF21 significantly promoted the functional recovery of SCI as assessed by BBB scale and inclined plane test, and attenuated cell death in the injured area by histopathological examination with Nissl staining. This was accompanied with increased expression of NeuN, GAP43 and NF200, and deceased expression of GFAP. Interestingly, FGF21 was found to attenuate the elevated expression level of the autophagy marker LC3-II (microtubules associated protein 1 light chain 3-II) induced by SCI in a dose-dependent manner. These data show that FGF21 promotes the functional recovery of SCI via restraining injury-induced cell autophagy, suggesting that systemic administration of FGF21 could have a therapeutic potential for SCI repair.

DNA vaccine against NgR promotes functional recovery after spinal cord injury in adult rats

2007 ◽  
Vol 1147 ◽  
pp. 66-76 ◽  
Author(s):  
Panpan Yu ◽  
Lidong Huang ◽  
Jian Zou ◽  
Huiqing Zhu ◽  
Xiaofei Wang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Dna Vaccine ◽  
Functional Recovery ◽  
Adult Rats ◽  
Cord Injury

MIC-1/GDF15 Overexpression Is Associated with Increased Functional Recovery in Traumatic Spinal Cord Injury

2019 ◽  
Vol 36 (24) ◽  
pp. 3410-3421 ◽  
Author(s):  
Masoud Hassanpour Golakani ◽  
Mohammad G. Mohammad ◽  
Hui Li ◽  
Joanne Gamble ◽  
Samuel N. Breit ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Traumatic Spinal Cord Injury ◽  
Cord Injury

DHAM-BMSC Matrix Promotes Axonal Regeneration and Functional Recovery After Spinal Cord Injury in Adult Rats

2009 ◽  
pp. 110306202455053
Author(s):  
Hongsheng Liang ◽  
Peng Liang ◽  
Ye Xu ◽  
Jianing Wu ◽  
Tao Liang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Axonal Regeneration ◽  
Adult Rats ◽  
Cord Injury

Upregulation of type I interleukin−1 receptor after traumatic spinal cord injury in adult rats

2006 ◽  
Vol 111 (3) ◽  
pp. 220-228 ◽  
Author(s):  
Xiao-Fei Wang ◽  
Li-Dong Huang ◽  
Pan-Pan Yu ◽  
Jian-Guo Hu ◽  
Lan Yin ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Interleukin 1 ◽  
Traumatic Spinal Cord Injury ◽  
Type I ◽  
Adult Rats ◽  
Cord Injury
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