Cerebrospinal Fluid Biomarkers To Stratify Injury Severity and Predict Outcome in Human Traumatic Spinal Cord Injury

2017 ◽  
Vol 34 (3) ◽  
pp. 567-580 ◽  
Author(s):  
Brian K. Kwon ◽  
Femke Streijger ◽  
Nader Fallah ◽  
Vanessa K. Noonan ◽  
Lise M. Bélanger ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cerebrospinal Fluid ◽  
Injury Severity ◽  
Traumatic Spinal Cord Injury ◽  
Cerebrospinal Fluid Biomarkers ◽  
Cord Injury

MicroRNA Biomarkers in Cerebrospinal Fluid and Serum Reflect Injury Severity in Human Acute Traumatic Spinal Cord Injury

2019 ◽  
Vol 36 (15) ◽  
pp. 2358-2371 ◽  
Author(s):  
Seth Tigchelaar ◽  
Rishab Gupta ◽  
Casey P. Shannon ◽  
Femke Streijger ◽  
Sunita Sinha ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cerebrospinal Fluid ◽  
Injury Severity ◽  
Traumatic Spinal Cord Injury ◽  
Cord Injury

MR Imaging for Assessing Injury Severity and Prognosis in Acute Traumatic Spinal Cord Injury

2019 ◽  
Vol 57 (2) ◽  
pp. 319-339 ◽  
Author(s):  
Jason F. Talbott ◽  
John Russell Huie ◽  
Adam R. Ferguson ◽  
Jacqueline C. Bresnahan ◽  
Michael S. Beattie ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Mr Imaging ◽  
Injury Severity ◽  
Traumatic Spinal Cord Injury ◽  
Cord Injury

Cerebrospinal Fluid Biomarkers in Human Spinal Cord Injury from a Phase II Minocycline Trial

2018 ◽  
Vol 35 (16) ◽  
pp. 1918-1928 ◽  
Author(s):  
Steve Casha ◽  
Tiffany Rice ◽  
David P. Stirling ◽  
Claudia Silva ◽  
Sharmilee Gnanapavan ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cerebrospinal Fluid ◽  
Phase Ii ◽  
Human Spinal Cord ◽  
Cerebrospinal Fluid Biomarkers ◽  
Cord Injury

scholarly journals Early Surgery for Traumatic Spinal Cord Injury: Where Are We Now?

2020 ◽  
Vol 10 (1_suppl) ◽  
pp. 84S-91S ◽  
Author(s):  
Jefferson R. Wilson ◽  
Christopher D. Witiw ◽  
Jetan Badhiwala ◽  
Brian K. Kwon ◽  
Michael G. Fehlings ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Injury Severity ◽  
Significant Proportion ◽  
Evidence Base ◽  
Narrative Review ◽  
Early Surgery ◽  
Traumatic Spinal Cord Injury ◽  
Cord Injury ◽  
Central Cord Syndrome

Study Design: Narrative review. Objective: There is a strong biological rationale to perform early decompression after traumatic spinal cord injury (SCI). With an enlarging clinical evidence base, most spine surgeons internationally now favor early decompression for the majority of SCI patients; however, a number of pertinent questions remain surrounding this therapy. Methods: A narrative review evaluating the status of early surgery for SCI. In particular, we addressed the following questions: (1) Which patients stand to benefit most from early surgery? 2) What is the most appropriate time threshold defining early surgery? Results: Although heterogeneity exists, the evidence generally seems to support early surgery. While the best evidence exists for cervical SCI, there is insufficient data to support a differential effect for early surgery depending on neurological level or injury severity. When comparing thresholds to define early versus late surgery—including a later threshold (48-72 hours), an earlier threshold (24 hours), and an ultra-early threshold (8-12 hours)—the 2 earlier time points seem to be associated with the greatest potential for improved outcomes. However, existing prehospital and hospital logistics pose barriers to early surgery in a significant proportion of patients. An overview of recommendations from the recent AOSpine guidelines is provided. Conclusion: In spite of increasing acceptance of early surgery post SCI, further research is needed to (1) identify subgroups of patients who stand to derive particular benefit—in particular to develop more evidence-based approaches for central cord syndrome and (2) investigate the efficacy and feasibility of ultra-early surgery targeting more aggressive timelines.

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