scholarly journals Dietary Docosahexaenoic Acid Improves Cognitive Function, Tissue Sparing, and Magnetic Resonance Imaging Indices of Edema and White Matter Injury in the Immature Rat after Traumatic Brain Injury

2016 ◽  
Vol 33 (4) ◽  
pp. 390-402 ◽  
Author(s):  
Michelle E. Schober ◽  
Daniela F. Requena ◽  
Osama M. Abdullah ◽  
T. Charles Casper ◽  
Joanna Beachy ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Traumatic Brain Injury ◽  
Cognitive Function ◽  
White Matter ◽  
Magnetic Resonance ◽  
White Matter Injury ◽  
Resonance Imaging ◽  
Immature Rat ◽  
Dietary Docosahexaenoic Acid ◽  
Tissue Sparing

Adverse effects of erenumab on cerebral proliferative angiopathy: A case report

Cephalalgia ◽  
2020 ◽  
pp. 033310242095048
Author(s):  
Laura L Lehman ◽  
Rebecca Bruccoleri ◽  
Amy Danehy ◽  
Julie Swanson ◽  
Christine Mrakotsky ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
Blood Brain Barrier ◽  
Vascular Malformations ◽  
Hippocampal Sclerosis ◽  
White Matter Injury ◽  
Brain Barrier ◽  
Resonance Imaging ◽  
Blood Brain

Background Cerebral proliferative angiopathy is a vascular malformation associated with compromised blood-brain barrier and with migraine-like headache. Treating blood-brain barrier-compromised patients with erenumab, an anti-calcitonin gene-related peptide receptor monoclonal antibody, may be risky. Case We describe a case of a 22-year-old chronic migraine patient with cerebral proliferative angiopathy who presented to our hospital in status epilepticus 2 d after his first dose of erenumab. Serial magnetic resonance imaging (MRI) studies demonstrated progressive areas of diffusion restriction including the brain tissue adjacent to the cerebral proliferative angiopathy, bilateral white matter and hippocampi. His 6-month post-presentation magnetic resonance imaging was notable for white matter injury, encephalomalacia surrounding cerebral proliferative angiopathy and bilateral hippocampal sclerosis. He remains clinically affected with residual symptoms, including refractory epilepsy and cognitive deficits. Conclusion The evidence presented in this case supports further investigation into potential deleterious side effects of erenumab in patients with compromised blood-brain barrier, such as individuals with intracranial vascular malformations.

scholarly journals Cognitive Function and 3-Tesla Magnetic Resonance Imaging Tractography of White Matter Hyperintensities in Elderly Persons

2015 ◽  
Vol 5 (3) ◽  
pp. 387-394 ◽  
Author(s):  
William Reginold ◽  
Angela C. Luedke ◽  
Angela Tam ◽  
Justine Itorralba ◽  
Juan Fernandez-Ruiz ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cognitive Function ◽  
White Matter ◽  
Magnetic Resonance ◽  
Fractional Anisotropy ◽  
White Matter Hyperintensities ◽  
Mean Diffusivity ◽  
Elderly Persons ◽  
Resonance Imaging ◽  
Wechsler Memory Scale

Background/Aims: This study used 3-Tesla magnetic resonance imaging (MRI) tractography to determine if there was an association between tracts crossing white matter hyperintensities (WMH) and cognitive function in elderly persons. Methods: Brain T2-weighted fluid-attenuated inversion recovery (FLAIR) and diffusion tensor MRI scans were acquired in participants above the age of 60 years. Twenty-six persons had WMH identified on T2 FLAIR scans. They completed a battery of neuropsychological tests and were classified as normal controls (n = 15) or with Alzheimer's dementia (n = 11). Tractography was generated by the Fiber Assignment by Continuous Tracking method. All tracts that crossed WMH were segmented. The average fractional anisotropy and average mean diffusivity of these tracts were quantified. We studied the association between cognitive test scores with the average mean diffusivity and average fractional anisotropy of tracts while controlling for age, total WMH volume and diagnosis. Results: An increased mean diffusivity of tracts crossing WMH was associated with worse performance on the Wechsler Memory Scale-III Longest Span Forward (p = 0.02). There was no association between the fractional anisotropy of tracts and performance on cognitive testing. Conclusion: The mean diffusivity of tracts crossing WMH measured by tractography is a novel correlate of performance on the Wechsler Memory Scale-III Longest Span Forward in elderly persons.

Differentiation between peritrigonal terminal zones and hypoxic-ischemic white matter injury on magnetic resonance imaging

2008 ◽  
Vol 32 (5) ◽  
pp. 415
Author(s):  
L. Liauw ◽  
J. van der Grand ◽  
V. Slooff ◽  
F. Wiggers-de-Bruine ◽  
L. Laan ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
White Matter Injury ◽  
Resonance Imaging

Postoperative Increase in Cerebral White Matter Fractional Anisotropy on Diffusion Tensor Magnetic Resonance Imaging Is Associated With Cognitive Improvement After Uncomplicated Carotid Endarterectomy

Neurosurgery ◽  
2013 ◽  
Vol 73 (4) ◽  
pp. 592-599 ◽  
Author(s):  
Yuiko Sato ◽  
Kenji Ito ◽  
Kuniaki Ogasawara ◽  
Makoto Sasaki ◽  
Kohsuke Kudo ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cognitive Function ◽  
White Matter ◽  
Magnetic Resonance ◽  
Spatial Statistics ◽  
Cerebral Hemisphere ◽  
Diffusion Tensor ◽  
Cerebral White Matter ◽  
Resonance Imaging ◽  
Cognitive Improvement

Abstract BACKGROUND: Carotid endarterectomy (CEA) might improve cognitive function. Fractional anisotropy (FA) values in the cerebral white matter derived from diffusion tensor magnetic resonance imaging (DTI) correlate with cognitive function in patients with various central nervous system diseases. OBJECTIVE: To use tract-based spatial statistics to determine whether postoperative changes of FA values in the cerebral white matter derived from DTI are associated with cognitive improvement after uncomplicated CEA. METHODS: In 80 patients undergoing CEA for ipsilateral internal carotid artery stenosis (≥70%), FA values in the cerebral white matter were derived from DTI before and 1 month after surgery and were analyzed by using tract-based spatial statistics. Neuropsychological testing, consisting of the Wechsler Adult Intelligence Scale Revised, the Wechsler Memory Scale and the Rey-Osterreith Complex Figure test, was also performed preoperatively and after the first postoperative month. RESULTS: Based on the neuropsychological assessments, 11 (14%) patients were defined as having postoperatively improved cognition. The difference between the 2 mean FA values (postoperative values minus preoperative values) in the cerebral hemisphere ipsilateral to surgery was significantly associated with postoperative cognitive improvement (95% confidence intervals, 2.632-9.877; P = .008). White matter FA values in patients with postoperative cognitive improvement were significantly increased after surgery in the whole ipsilateral cerebral hemisphere, in the contralateral anterior cerebral artery territory, and in the watershed zone between the contralateral anterior and middle cerebral arteries. CONCLUSION: Postoperative increase in cerebral white matter FA on DTI is associated with cognitive improvement after uncomplicated CEA.

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