scholarly journals Spinal Interneurons and Forelimb Plasticity after Incomplete Cervical Spinal Cord Injury in Adult Rats

2015 ◽  
Vol 32 (12) ◽  
pp. 893-907 ◽  
Author(s):  
Elisa Janine Gonzalez-Rothi ◽  
Angela M. Rombola ◽  
Celeste A. Rousseau ◽  
Lynne M. Mercier ◽  
Garrett M. Fitzpatrick ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cervical Spinal Cord ◽  
Cervical Spinal Cord Injury ◽  
Adult Rats ◽  
Spinal Interneurons ◽  
Cord Injury

scholarly journals Neuronal progenitor transplantation and respiratory outcomes following upper cervical spinal cord injury in adult rats

2010 ◽  
Vol 225 (1) ◽  
pp. 231-236 ◽  
Author(s):  
Todd E. White ◽  
Michael A. Lane ◽  
Milapjit S. Sandhu ◽  
Barbara E. O'Steen ◽  
David D. Fuller ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cervical Spinal Cord ◽  
Cervical Spinal Cord Injury ◽  
Adult Rats ◽  
Neuronal Progenitor ◽  
Cord Injury ◽  
Upper Cervical ◽  
Respiratory Outcomes

scholarly journals Cervical Spinal Cord Injury Leads to Injury and Metabolic Dysfunction of the Lung

2021 ◽  
Author(s):  
Emily E Huffman ◽  
Brittany E Dong ◽  
Harrison A Clarke ◽  
Lyndsay EA Young ◽  
Derek B Allison ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Lung Injury ◽  
Cervical Spinal Cord ◽  
Cervical Spinal Cord Injury ◽  
Lung Damage ◽  
Ionization Mass ◽  
Metabolic Dysfunction ◽  
Adult Rats ◽  
Cord Injury

High-cervical spinal cord injury (SCI) often disrupts respiratory motor pathways and disables breathing in the affected population. Moreover, cervically injured individuals are at risk for developing acute lung injury (ALI), which predicts substantial mortality rates. While the correlation between ALI and SCI has been found in the clinical setting, the field lacks an animal model to interrogate the fundamental biology of this relationship. To begin to address this gap, we performed an experimental cervical SCI and assessed lung injury in adult rats. We demonstrate that animals display signs of ALI two weeks post-SCI. We also observed aberrant N-glycan metabolism determined by matrix-assisted laser desorption/ionization mass spectrometry imaging. Collectively, we establish for the first time a model of ALI after SCI at an acute time point that can be used to monitor the progression of lung damage, as well as identify potential targets to ameliorate ALI.

Delayed Intervention with Transplants and Neurotrophic Factors Supports Recovery of Forelimb Function after Cervical Spinal Cord Injury in Adult Rats

2006 ◽  
Vol 23 (5) ◽  
pp. 617-634 ◽  
Author(s):  
James V. Lynskey ◽  
Faheem A. Sandhu ◽  
Hai-Ning Dai ◽  
Marietta McAtee ◽  
Jonathan R. Slotkin ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neurotrophic Factors ◽  
Cervical Spinal Cord ◽  
Cervical Spinal Cord Injury ◽  
Adult Rats ◽  
Cord Injury ◽  
Delayed Intervention
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