Conservatively Treated Ossification of the Posterior Longitudinal Ligament Increases the Risk of Spinal Cord Injury: A Nationwide Cohort Study

2012 ◽  
Vol 29 (3) ◽  
pp. 462-468 ◽  
Author(s):  
Jau-Ching Wu ◽  
Yu-Chun Chen ◽  
Laura Liu ◽  
Wen-Cheng Huang ◽  
Tzeng-Ji Chen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cohort Study ◽  
Posterior Longitudinal Ligament ◽  
Cord Injury

scholarly journals Risk of spinal cord injury in patients with cervical spondylotic myelopathy and ossification of posterior longitudinal ligament: a national cohort study

2016 ◽  
Vol 40 (6) ◽  
pp. E4 ◽  
Author(s):  
Li-Fu Chen ◽  
Tsung-Hsi Tu ◽  
Yu-Chun Chen ◽  
Jau-Ching Wu ◽  
Peng-Yuan Chang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cohort Study ◽  
Lower Incidence ◽  
Cervical Spondylotic Myelopathy ◽  
Cox Regression ◽  
Posterior Longitudinal Ligament ◽  
Incidence Rates ◽  
Cord Injury ◽  
Male Patients

OBJECTIVE This study aimed to estimate the risk of spinal cord injury (SCI) in patients with cervical spondylotic myelopathy (CSM) with and without ossification of posterior longitudinal ligament (OPLL). Also, the study compared the incidence rates of SCI in patients who were managed surgically and conservatively. METHODS This retrospective cohort study covering 15 years analyzed the incidence of SCI in patients with CSM. All patients, identified from the National Health Insurance Research Database, were hospitalized with the diagnosis of CSM and followed up during the study period. These patients with CSM were categorized into 4 groups according to whether they had OPLL or not and whether they received surgery or not: 1) surgically managed CSM without OPLL; 2) conservatively managed CSM without OPLL; 3) surgically managed CSM with OPLL; and 4) conservatively managed CSM with OPLL. The incidence rates of subsequent SCI in each group during follow-up were then compared. Kaplan-Meier and Cox regression analyses were performed to compare the risk of SCI between the groups. RESULTS Between January 1, 1999, and December 31, 2013, there were 17,258 patients with CSM who were followed up for 89,003.78 person-years. The overall incidence of SCI in these patients with CSM was 2.022 per 1000 person-years. Patients who had CSM with OPLL and were conservatively managed had the highest incidence of SCI, at 4.11 per 1000 person-years. Patients who had CSM with OPLL and were surgically managed had a lower incidence of SCI, at 3.69 per 1000 person-years. Patients who had CSM without OPLL and were conservatively managed had an even lower incidence of SCI, at 2.41 per 1000 person-years. Patients who had CSM without OPLL and were surgically managed had the lowest incidence of SCI, at 1.31 per 1000 person-years. The Cox regression model demonstrated that SCIs are significantly more likely to happen in male patients and in those with OPLL (HR 2.00 and 2.24, p < 0.001 and p = 0.007, respectively). Surgery could significantly lower the risk for approximately 50% of patients (HR 0.52, p < 0.001). CONCLUSIONS Patients with CSM had an overall incidence rate of SCI at approximately 0.2% per year. Male sex, the coexistence of OPLL, and conservative management are twice as likely to be associated with subsequent SCI. Surgery is therefore suggested for male patients with CSM who also have OPLL.

scholarly journals Investigation of bias due to loss of participants in a Dutch multicentre prospective spinal cord injury cohort study

2009 ◽  
Vol 41 (5) ◽  
pp. 382-389 ◽  
Author(s):  
S de Groot ◽  
JA Haisma ◽  
MWM Post ◽  
FWA van Asbeck ◽  
LHV van der Woude
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cohort Study ◽  
Cord Injury

Employment Trajectories After Spinal Cord Injury: Results From a 5-Year Prospective Cohort Study

2014 ◽  
Vol 95 (11) ◽  
pp. 2040-2046 ◽  
Author(s):  
Astri Ferdiana ◽  
Marcel W. Post ◽  
Trynke Hoekstra ◽  
Luccas H. van der Woude ◽  
Jac J. van der Klink ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Employment Trajectories ◽  
Cord Injury

scholarly journals Treatment patterns of in-patient spasticity medication use after traumatic spinal cord injury: a prospective cohort study

Spinal Cord ◽  
2018 ◽  
Vol 56 (12) ◽  
pp. 1176-1183 ◽  
Author(s):  
Kaila A. Holtz ◽  
Elena Szefer ◽  
Vanessa K Noonan ◽  
Brian K. Kwon ◽  
Patricia B. Mills
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Medication Use ◽  
Treatment Patterns ◽  
Traumatic Spinal Cord Injury ◽  
Cord Injury
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