Gene Therapy for Traumatic Central Nervous System Injury and Stroke Using an Engineered Zinc Finger Protein that Upregulates VEGF-A

2011 ◽  
Vol 28 (9) ◽  
pp. 1863-1879 ◽  
Author(s):  
Philippe M. D'Onofrio ◽  
Mahinthan Thayapararajah ◽  
Meghan D. Lysko ◽  
Mark Magharious ◽  
S. Kaye Spratt ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Central Nervous System ◽  
Nervous System ◽  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Central Nervous System Injury ◽  
Finger Protein

ming is expressed in neuroblast sublineages and regulates gene expression in the Drosophila central nervous system

Development ◽  
1992 ◽  
Vol 116 (4) ◽  
pp. 943-952 ◽  
Author(s):  
X. Cui ◽  
C.Q. Doe
Keyword(s):  
Gene Expression ◽  
Central Nervous System ◽  
Nervous System ◽  
Cell Fate ◽  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Cell Lineage ◽  
Cell Lineages ◽  
Finger Protein ◽  
Cell Diversity

Cell diversity in the Drosophila central nervous system (CNS) is primarily generated by the invariant lineage of neural precursors called neuroblasts. We used an enhancer trap screen to identify the ming gene, which is transiently expressed in a subset of neuroblasts at reproducible points in their cell lineage (i.e. in neuroblast ‘sublineages’), suggesting that neuroblast identity can be altered during its cell lineage. ming encodes a predicted zinc finger protein and loss of ming function results in precise alterations in CNS gene expression, defects in axonogenesis and embryonic lethality. We propose that ming controls cell fate within neuroblast cell lineages.

Treatment of Traumatic Brain Injury Using Zinc-Finger Protein Gene Therapy Targeting VEGF-A

2012 ◽  
Vol 29 (17) ◽  
pp. 2647-2659 ◽  
Author(s):  
Ishita Siddiq ◽  
Eugene Park ◽  
Elaine Liu ◽  
S. Kaye Spratt ◽  
Richard Surosky ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Gene Therapy ◽  
Brain Injury ◽  
Zinc Finger ◽  
Protein Gene ◽  
Zinc Finger Protein ◽  
Zinc Finger Protein Gene ◽  
Finger Protein

Expression of theKrüppel-type zinc finger protein rKr2 in the developing nervous system†

Glia ◽  
2001 ◽  
Vol 34 (2) ◽  
pp. 110-120 ◽  
Author(s):  
Gabor Lovas ◽  
Wen Li ◽  
Uwe Pott ◽  
Trevor Verga ◽  
Lynn D. Hudson
Keyword(s):  
Nervous System ◽  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Finger Protein ◽  
Developing Nervous System

Stimulus-Transcription Coupling in the Nervous System: The Zinc Finger Protein Egr-1

2006 ◽  
pp. 379-395 ◽  
Author(s):  
Oliver G. Rössler ◽  
Luisa Stefano ◽  
Inge Bauer ◽  
Gerald Thiel
Keyword(s):  
Nervous System ◽  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Finger Protein
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