Time-Dependent Changes in Serum Biomarker Levels after Blast Traumatic Brain Injury

2011 ◽  
Vol 28 (6) ◽  
pp. 1121-1126 ◽  
Author(s):  
Andrea Gyorgy ◽  
Geoffrey Ling ◽  
Daniel Wingo ◽  
John Walker ◽  
Lawrence Tong ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Time Dependent ◽  
Serum Biomarker ◽  
Blast Traumatic Brain Injury

Time-dependent changes of protein biomarker levels in the cerebrospinal fluid after blast traumatic brain injury

2012 ◽  
Vol 33 (24) ◽  
pp. 3705-3711 ◽  
Author(s):  
Farid Ahmed ◽  
Andrea Gyorgy ◽  
Alaa Kamnaksh ◽  
Geoffrey Ling ◽  
Lawrence Tong ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Cerebrospinal Fluid ◽  
Brain Injury ◽  
Time Dependent ◽  
Protein Biomarker ◽  
Blast Traumatic Brain Injury

scholarly journals Allocation of funding into blast injury-related research and blast traumatic brain injury between 2000 and 2019: analysis of global investments from public and philanthropic funders

2020 ◽  
pp. bmjmilitary-2020-001655
Author(s):  
J W Denny ◽  
R J Brown ◽  
M G Head ◽  
J Batchelor ◽  
A S Dickinson
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Open Data ◽  
Blast Injury ◽  
Included Study ◽  
Related Research ◽  
Blast Traumatic Brain Injury ◽  
Research Investment ◽  
Ear Injury ◽  
Injury Research

IntroductionThere is little systematic tracking or detailed analysis of investments in research and development for blast injury to support decision-making around research future funding.MethodsThis study examined global investments into blast injury-related research from public and philanthropic funders across 2000–2019. Research databases were searched using keywords, and open data were extracted from funder websites. Data collected included study title, abstract, award amount, funder and year. Individual awards were categorised to compare amounts invested into different blast injuries, the scientific approaches taken and analysis of research investment into blast traumatic brain injury (TBI).ResultsA total of 806 awards were identified into blast injury-related research globally, equating to US$902.1 million (m, £565.9m GBP). There was a general increase in year-on-year investment between 2003 and 2009 followed by a consistent decline in annual funding since 2010. Pre-clinical research received $671.3 m (74.4%) of investment. Brain-related injury research received $427.7 m (47.4%), orthopaedic injury $138.6 m (15.4%), eye injury $63.7 m (7.0%) and ear injury $60.5m (6.7%). Blast TBI research received a total investment of $384.3 m, representing 42.6% of all blast injury-related research. The U.S. Department of Defense funded $719.3 m (80%).ConclusionsInvestment data suggest that blast TBI research has received greater funding than other blast injury health areas. The funding pattern observed can be seen as reactive, driven by the response to the War on Terror, the rising profile of blast TBI and congressionally mandated research.

scholarly journals Time-Dependent Changes in Microglia Transcriptional Networks Following Traumatic Brain Injury

2019 ◽  
Vol 13 ◽  
Author(s):  
Saef Izzy ◽  
Qiong Liu ◽  
Zhou Fang ◽  
Sevda Lule ◽  
Limin Wu ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Time Dependent ◽  
Transcriptional Networks

The Prognostic Significance of the Serum Biomarker Heart-Fatty Acidic Binding Protein in Comparison with S100b in Severe Traumatic Brain Injury

2013 ◽  
Vol 30 (19) ◽  
pp. 1631-1637 ◽  
Author(s):  
Bernhard Walder ◽  
Xavier Robin ◽  
Marie My Lien Rebetez ◽  
Jean-Christophe Copin ◽  
Yvan Gasche ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Severe Traumatic Brain Injury ◽  
Binding Protein ◽  
Prognostic Significance ◽  
Serum Biomarker

Severe Traumatic Brain Injury

2018 ◽  
Author(s):  
Ryan Martin ◽  
Lara Zimmermann ◽  
Kee D. Kim ◽  
Marike Zwienenberg ◽  
Kiarash Shahlaie
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Intracranial Pressure ◽  
Severe Traumatic Brain Injury ◽  
Neurocritical Care ◽  
Secondary Brain Injury ◽  
Brain Oxygenation ◽  
Barbiturate Coma ◽  
Blast Traumatic Brain Injury ◽  
Penetrating Traumatic Brain Injury

Traumatic brain injury remains a leading cause of death and disability worldwide. Patients with severe traumatic brain injury are best treated with a multidisciplinary, evidence-based, protocol-directed approach, which has been shown to decrease mortality and improve functional outcomes. Therapy is directed at the prevention of secondary brain injury through optimizing cerebral blood flow and the delivery of metabolic fuel (ie, oxygen and glucose). This is accomplished through the measurement and treatment of elevated intracranial pressure (ICP), the strict avoidance of hypotension and hypoxemia, and in some instances, surgical management. The treatment of elevated ICP is approached in a protocolized, tiered manner, with escalation of care occurring in the setting of refractory intracranial hypertension, culminating in either decompressive surgery or barbiturate coma. With such an approach, the rates of mortality secondary to traumatic brain injury are declining despite an increasing incidence of traumatic brain injury. This review contains 3 figures, 5 tables and 69 reference Key Words: blast traumatic brain injury, brain oxygenation, cerebral perfusion pressure, decompressive craniectomy, hyperosmolar therapy, intracranial pressure, neurocritical care, penetrating traumatic brain injury, severe traumatic brain injury

scholarly journals SUN-477 Chronic Variable Stress Worsens Effects of Mild Blast Traumatic Brain Injury on the Stress Response

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Mario Oyola ◽  
Ashley Russell ◽  
Lauren Miller ◽  
Robert Handa ◽  
Tao-Yiao Wu
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Stress Response ◽  
Blast Traumatic Brain Injury ◽  
Chronic Variable Stress

scholarly journals Time-dependent differences in cortical measures and their associations with behavioral measures following mild traumatic brain injury

2018 ◽  
Vol 39 (5) ◽  
pp. 1886-1897 ◽  
Author(s):  
Sahil Bajaj ◽  
Natalie S. Dailey ◽  
Isabelle M. Rosso ◽  
Scott L. Rauch ◽  
William D. S. Killgore
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Time Dependent ◽  
Behavioral Measures

Blast Traumatic Brain Injury Mechanisms

Neurotrauma ◽  
2018 ◽  
pp. 111-122
Author(s):  
Elizabeth McNeil ◽  
Zachary Bailey ◽  
Allison Guettler ◽  
Pamela VandeVord
Keyword(s):  
Traumatic Brain Injury ◽  
Finite Element ◽  
Brain Injury ◽  
Head Injury ◽  
Mechanism Of Injury ◽  
Primary Blast ◽  
Blast Traumatic Brain Injury ◽  
Injury Mechanisms ◽  
Biomechanical Investigation

Blast traumatic brain injury (bTBI) is a leading cause of head injury in soldiers returning from the battlefield. Primary blast brain injury remains controversial with little evidence to support a primary mechanism of injury. The four main theories described herein include blast wave transmission through skull orifices, direct cranial transmission, thoracic surge, and skull flexure dynamics. It is possible that these mechanisms do not occur exclusively from each other, but rather that several of them lead to primary blast brain injury. Biomechanical investigation with in-vivo, cadaver, and finite element models would greatly increase our understanding of bTBI mechanisms.

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