scholarly journals Early and Sustained Alterations in Cerebral Metabolism after Traumatic Brain Injury in Immature Rats

2008 ◽  
Vol 25 (6) ◽  
pp. 603-614 ◽  
Author(s):  
Paula A. Casey ◽  
Mary C. McKenna ◽  
Gary Fiskum ◽  
Manda Saraswati ◽  
Courtney L. Robertson
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cerebral Metabolism ◽  
Immature Rats

TRAUMATIC BRAIN INJURY IN IMMATURE RATS CAUSES EARLY AND SUSTAINED ALTERATIONS IN CEREBRAL METABOLISM.

2006 ◽  
Vol 34 ◽  
pp. A17 ◽  
Author(s):  
Paula Casey ◽  
Mary McKenna ◽  
Manda Saraswati ◽  
Courtney Robertson ◽  
Gary Fiskum
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cerebral Metabolism ◽  
Immature Rats

Cerebral Metabolism and Blood Flow Following Traumatic Brain Injury

2018 ◽  
Author(s):  
Ryan Martin ◽  
Lara Zimmermann ◽  
Marike Zwienenberg ◽  
Kee D Kim ◽  
Kiarash Shahlaie
Keyword(s):  
Traumatic Brain Injury ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Brain Injury ◽  
Intracranial Pressure ◽  
Cerebral Autoregulation ◽  
Cerebral Metabolism ◽  
Elevated Intracranial Pressure ◽  
Metabolic Demand ◽  
Cerebral Metabolic Rate

The management of traumatic brain injury focuses on the prevention of second insults, which most often occur because of a supply/demand mismatch of the cerebral metabolism. The healthy brain has mechanisms of autoregulation to match the cerebral blood flow to the cerebral metabolic demand. After trauma, these mechanisms are disrupted, leaving the patient susceptible to episodes of hypotension, hypoxemia, and elevated intracranial pressure. Understanding the normal and pathologic states of the cerebral blood flow is critical for understanding the treatment choices for a patient with traumatic brain injury. In this chapter, we discuss the underlying physiologic principles that govern our approach to the treatment of traumatic brain injury. This review contains 3 figures, 1 table and 12 references Key Words: cerebral autoregulation, cerebral blood flow, cerebral metabolic rate, intracranial pressure, ischemia, reactivity, vasoconstriction, vasodilation, viscosity

Pathophysiology of traumatic brain injury

2019 ◽  
pp. 483-496
Author(s):  
Geoffrey T. Manley ◽  
John K. Yue ◽  
Hansen Deng ◽  
Ethan A. Winkler ◽  
John F. Burke ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Injury Severity ◽  
Cerebral Metabolism ◽  
Classification Systems ◽  
Reactivity Index ◽  
Management Options ◽  
Diagnosis And Prognosis ◽  
Flow Disturbances

This chapter provides summative information on the biomechanics, classification, and metabolism of traumatic brain injury (TBI). Impact, impulse, static/quasistatic loading, and related biomechanical sequelae following rotational shear and strain are discussed. Morphological classifications across extradural, acute/chronic subdural, subarachnoid, and intraventricular haemorrhages, as well as cerebral contusions and axonal injuries, are characterized and correlated with injury severity. Management options and implications for penetrating TBI and mild TBI/concussion are described. Cerebral metabolism including pressure/viscosity, CO2 reactivity, and autoregulation are explained in detail to provide for in-depth exploration of a spectrum of secondary injury cascades, encompassing glutamatergic excitotoxicity, autoregulatory loss, and the pressure reactivity index, flow disturbances, elevated intracranial pressure, cortical spreading depression and seizures/epilepsy. Beta-amyloid deposition in response to TBI, and genetic susceptibilities to poor recovery are covered. Current developments to standardize TBI classification systems, establish evidentiary benchmarks for quality of care, and accelerate advances in diagnosis and prognosis are highlighted.

scholarly journals Post-traumatic hypoxia exacerbates neurological deficit, neuroinflammation and cerebral metabolism in rats with diffuse traumatic brain injury

2011 ◽  
Vol 8 (1) ◽  
pp. 147 ◽  
Author(s):  
Edwin B Yan ◽  
Sarah C Hellewell ◽  
Bo-Michael Bellander ◽  
Doreen A Agyapomaa ◽  
M Cristina Morganti-Kossmann
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Neurological Deficit ◽  
Cerebral Metabolism ◽  
Post Traumatic

HYPOTHERMIA FAILS TO REDUCE LESION VOLUME AFTER TRAUMATIC BRAIN INJURY IN IMMATURE RATS

1994 ◽  
Vol 22 (1) ◽  
pp. A171
Author(s):  
Robert Mansfield ◽  
Joanne Schiding ◽  
Ron Hamilton ◽  
Patrick Kochanek
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Lesion Volume ◽  
Immature Rats

The effects of α-lipoic acid on immature rats with traumatic brain injury

2014 ◽  
Vol 90 (3) ◽  
pp. 206-215 ◽  
Author(s):  
S Ozbal ◽  
U Cankurt ◽  
K Tugyan ◽  
C Pekcetin ◽  
Ar Sisman ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Lipoic Acid ◽  
Immature Rats

Neuroprotective effects of MK-801 against traumatic brain injury in immature rats

2015 ◽  
Vol 597 ◽  
pp. 137-142 ◽  
Author(s):  
Ataç Sönmez ◽  
Oya Sayın ◽  
Seren Gülşen Gürgen ◽  
Meryem Çalişir
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Neuroprotective Effects ◽  
Mk 801 ◽  
Immature Rats
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