Neuroprotective Effects of Gacyclidine After Experimental Photochemical Spinal Cord Lesion in Adult Rats: Dose-Window and Time-Window Effects

2000 ◽  
Vol 17 (1) ◽  
pp. 19-30 ◽  
Author(s):  
MANUEL GAVIRIA ◽  
ALAIN PRIVAT ◽  
PIERRE d'ARBIGNY ◽  
JEAN-MARC KAMENKA ◽  
HENRI HATON ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Time Window ◽  
Spinal Cord Lesion ◽  
Neuroprotective Effects ◽  
Adult Rats ◽  
Window Effects ◽  
Cord Lesion

scholarly journals Distant microglial and astroglial activation secondary to experimental spinal cord lesion

2001 ◽  
Vol 59 (3A) ◽  
pp. 483-492 ◽  
Author(s):  
Ricardo José de Almeida Leme ◽  
Gerson Chadi
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Lesion ◽  
Scar Formation ◽  
Reactive Astrocytes ◽  
Computer Assisted ◽  
Phagocytic Cells ◽  
Adult Rats ◽  
Thoracic Level ◽  
Gray Matters ◽  
Cord Lesion

This paper analysed whether glial responses following a spinal cord lesion is restricted to a scar formation close to the wound or they might be also related to widespread paracrine trophic events in the entire cord. Spinal cord hemitransection was performed in adult rats at the thoracic level. Seven days and three months later the spinal cords were removed and submitted to immunohistochemistry of glial fibrillary acidic protein (GFAP) and OX42, markers for astrocytes and microglia, as well as of basic fibroblast growth factor (bFGF), an astroglial neurotrophic factor. Computer assisted image analysis was employed in the quantification of the immunoreactivity changes. At the lesion site an increased number of GFAP positive astrocytes and OX42 positive phagocytic cells characterized a dense scar formation by seven days, which was further augmented after three months. Morphometric analysis of the area and microdensitometric analysis of the intensity of the GFAP and OX42 immunoreactivities showed reactive astrocytes and microglia in the entire spinal cord white and gray matters 7 days and 3 months after surgery. Double immunofluorescence demonstrated increased bFGF immunostaining in reactive astrocytes. The results indicated that glial reaction close to an injury site of the spinal cord is related to wounding and repair events. Although gliosis constitutes a barrier to axonal regeneration, glial activation far from the lesion may contribute to neuronal trophism and plasticity in the lesioned spinal cord favoring neuronal maintenance and fiber outgrowth.

scholarly journals Anti-amphiphysin antibody-positive paraneoplastic neurological syndrome with a longitudinally extensive spinal cord lesion of the dorsal column

2014 ◽  
Vol 54 (7) ◽  
pp. 572-576 ◽  
Author(s):  
Shuichiro Neshige ◽  
Naoyuki Hara ◽  
Shinichi Takeshima ◽  
Hirotaka Iwaki ◽  
Yutaka Shimoe ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Paraneoplastic Neurological Syndrome ◽  
Dorsal Column ◽  
Spinal Cord Lesion ◽  
Neurological Syndrome ◽  
Cord Lesion

Cross-cultural adaptation of the spinal cord lesion-related coping strategies questionnaire for use in Iran

Injury ◽  
2015 ◽  
Vol 46 (8) ◽  
pp. 1539-1544 ◽  
Author(s):  
Mohsen Saffari ◽  
Amir H. Pakpour ◽  
Mohammad Yaghobidoot ◽  
Faten Al Zaben ◽  
Harold G. Koenige
Keyword(s):  
Spinal Cord ◽  
Coping Strategies ◽  
Cultural Adaptation ◽  
Spinal Cord Lesion ◽  
Cross Cultural ◽  
Cross Cultural Adaptation ◽  
Cord Lesion

Reduction of Common Synaptic Drive to Ankle Dorsiflexor Motoneurons During Walking in Patients With Spinal Cord Lesion

2005 ◽  
Vol 94 (2) ◽  
pp. 934-942 ◽  
Author(s):  
N. L. Hansen ◽  
B. A. Conway ◽  
D. M. Halliday ◽  
S. Hansen ◽  
H. S. Pyndt ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Motor Unit ◽  
Healthy Subjects ◽  
Motor Units ◽  
Central Peak ◽  
Spinal Cord Lesion ◽  
Short Term ◽  
Physiological Markers ◽  
Synaptic Drive ◽  
Cord Lesion

It is possible to obtain information about the synaptic drive to motoneurons during walking by analyzing motor-unit coupling in the time and frequency domains. The purpose of the present study was to compare motor-unit coupling during walking in healthy subjects and patients with incomplete spinal cord lesion to obtain evidence of differences in the motoneuronal drive that result from the lesion. Such information is of importance for development of new strategies for gait restoration. Twenty patients with incomplete spinal cord lesion (SCL) participated in the study. Control experiments were performed in 11 healthy subjects. In all healthy subjects, short-term synchronization was evident in the discharge of tibialis anterior (TA) motor units during the swing phase of treadmill walking. This was identified from the presence of a narrow central peak in cumulant densities constructed from paired EMG recordings and from the presence of significant coherence between these signals in the 10- to 20-Hz band. Such indicators of short-term synchrony were either absent or very small in the patient group. The relationship between the amount of short-term synchrony and the magnitude of the 10- to 20-Hz coherence in the patients is discussed in relation to gait ability. It is suggested that supraspinal drive to the spinal cord is responsible for short-term synchrony and coherence in the 10- to 20-Hz frequency band during walking in healthy subjects. Absence or reduction of these features may serve as physiological markers of impaired supraspinal control of gait in SCL patients. Such markers could have diagnostic and prognostic value in relation to the recovery of locomotion in patients with central motor lesions.

scholarly journals A retrospective study on female urological surgeries over the 10 years following spinal cord lesion

Spinal Cord ◽  
2013 ◽  
Vol 51 (9) ◽  
pp. 688-693 ◽  
Author(s):  
G Lombardi ◽  
S Musco ◽  
M Celso ◽  
A Ierardi ◽  
F Nelli ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Retrospective Study ◽  
Spinal Cord Lesion ◽  
Cord Lesion
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