Novel MicroRNA Sponges to Specifically Modulate Gene Expression in Colon Cancer Cells

2020 ◽  
Vol 30 (5) ◽  
pp. 325-334
Author(s):  
Ana R. Rama ◽  
Gloria Perazzoli ◽  
Laura Cabeza ◽  
Cristina Mesas ◽  
Francisco Quiñonero ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colon Cancer ◽  
Cancer Cells ◽  
Colon Cancer Cells ◽  
Microrna Sponges

scholarly journals AS601245, an Anti-Inflammatory JNK Inhibitor, and Clofibrate Have a Synergistic Effect in Inducing Cell Responses and in Affecting the Gene Expression Profile in CaCo-2 Colon Cancer Cells

PPAR Research ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-16 ◽  
Author(s):  
Angelo Cerbone ◽  
Cristina Toaldo ◽  
Stefania Pizzimenti ◽  
Piergiorgio Pettazzoni ◽  
Chiara Dianzani ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colon Cancer ◽  
Cell Proliferation ◽  
Cancer Cells ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Combined Treatment ◽  
Colon Cancer Cells ◽  
Positive Interaction ◽  
Anti Inflammatory

PPARαs are nuclear receptors highly expressed in colon cells. They can be activated by the fibrates (clofibrate, ciprofibrate etc.) used to treat hyperlipidemia. Since PPARαtranscriptional activity can be negatively regulated by JNK, the inhibition of JNK activity could increase the effectiveness of PPARαligands. We analysed the effects of AS601245 (a JNK inhibitor) and clofibrate alone or in association, on proliferation, apoptosis, differentiation and the gene expression profile of CaCo-2 human colon cancer cells. Proliferation was inhibited in a dose-dependent way by clofibrate and AS601245. Combined treatment synergistically reduced cell proliferation, cyclin D1 and PCNA expression and induced apoptosis and differentiation. Reduction of cell proliferation, accompanied by the modulation of p21 expression was observed in HepG2 cells, also. Gene expression analysis revealed that some genes were highly modulated by the combined treatment and 28 genes containing PPRE were up-regulated, while clofibrate alone was ineffective. Moreover, STAT3 signalling was strongly reduced by combined treatment. After combined treatment, the binding of PPARαto PPRE increased and paralleled with the expression of the PPAR coactivator MED1. Results demonstrate that combined treatment increases the effectiveness of both compounds and suggest a positive interaction between PPARαligands and anti-inflammatory agents in humans.

Gene expression profiles of folate deficient colon cancer cells

2003 ◽  
Vol 124 (4) ◽  
pp. A239
Author(s):  
Petar Novakovic ◽  
Kyoung-Jin Sohn ◽  
Young-In J. Kim
Keyword(s):  
Gene Expression ◽  
Colon Cancer ◽  
Cancer Cells ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Colon Cancer Cells

scholarly journals Dendrosomal Curcumin Inhibits Metastatic Potential of Human SW480 Colon Cancer Cells through Down-regulation of Claudin1, Zeb1 and Hef1-1 Gene Expression

2015 ◽  
Vol 16 (6) ◽  
pp. 2473-2481 ◽  
Author(s):  
Mohammad Javad Dehghan Esmatabadi ◽  
Baharak Farhangi ◽  
Zahra Safari ◽  
Hanif Kazerooni ◽  
Hadi Shirzad ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colon Cancer ◽  
Cancer Cells ◽  
Metastatic Potential ◽  
Colon Cancer Cells ◽  
Down Regulation

scholarly journals Interaction of colon cancer cells with glycoconjugates triggers complex changes in gene expression, glucose transporters and cell invasion

2018 ◽  
Author(s):  
Romana Křivohlav� ◽  
Valika Grob�rov� ◽  
Eva Neuh�ferov� ◽  
Anna Fišerov� ◽  
Veronika Benson
Keyword(s):  
Gene Expression ◽  
Colon Cancer ◽  
Cancer Cells ◽  
Cell Invasion ◽  
Glucose Transporters ◽  
Colon Cancer Cells
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