Approaches for Systemic Delivery of Dystrophin Antisense Peptide Nucleic Acid in the mdx Mouse Model

2020 ◽  
Author(s):  
Camilla Brolin ◽  
Ernest Wee Kiat Lim ◽  
Sylvestre Grizot ◽  
Caroline Holkmann Olsen ◽  
Niloofar Yavari ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Mouse Model ◽  
Peptide Nucleic Acid ◽  
Mdx Mouse ◽  
Systemic Delivery ◽  
Antisense Peptide

Antisense peptide nucleic acid targeting GluR3 delays disease onset and progression in the SOD1 G93A mouse model of familial ALS

2004 ◽  
Vol 77 (4) ◽  
pp. 573-582 ◽  
Author(s):  
Alan Rembach ◽  
Bradley J. Turner ◽  
Stephen Bruce ◽  
Irwin K. Cheah ◽  
Rachel L. Scott ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Mouse Model ◽  
Peptide Nucleic Acid ◽  
Disease Onset ◽  
Familial Als ◽  
Antisense Peptide ◽  
Sod1 G93a Mouse

scholarly journals Optimization of Peptide Nucleic Acid Antisense Oligonucleotides for Local and Systemic Dystrophin Splice Correction in the mdx Mouse

2010 ◽  
Vol 18 (4) ◽  
pp. 819-827 ◽  
Author(s):  
HaiFang Yin ◽  
Corinne Betts ◽  
Amer F Saleh ◽  
Gabriela D Ivanova ◽  
Hyunil Lee ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Antisense Oligonucleotides ◽  
Mdx Mouse

scholarly journals Antimicrobial activity of antisense peptide–peptide nucleic acid conjugates against non-typeableHaemophilus influenzaein planktonic and biofilm forms

2016 ◽  
Vol 72 (1) ◽  
pp. 137-144 ◽  
Author(s):  
Taketo Otsuka ◽  
Aimee L. Brauer ◽  
Charmaine Kirkham ◽  
Erin K. Sully ◽  
Melinda M. Pettigrew ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Antisense Peptide

147: Intra Vesical Admininstration of Antisense Peptide Nucleic Acid Down Regulates Urothelial NGF Expression in Rat Model of Cystitis

2005 ◽  
Vol 173 (4S) ◽  
pp. 40-40
Author(s):  
Pradeep Tyagi ◽  
Michael B. Chancellor ◽  
Naoki Yoshimura ◽  
Leaf Huang
Keyword(s):  
Nucleic Acid ◽  
Rat Model ◽  
Peptide Nucleic Acid ◽  
Antisense Peptide

mazE Antitoxin of Toxin Antitoxin System and fbpA as Reliable Targets to Eradication of Neisseria meningitidis

2018 ◽  
Vol 24 (11) ◽  
pp. 1204-1210 ◽  
Author(s):  
Abbas Maleki ◽  
Sobhan Ghafourian ◽  
Iraj Pakzad ◽  
Behzad Badakhsh ◽  
Nourkhoda Sadeghifard
Keyword(s):  
Nucleic Acid ◽  
Neisseria Meningitidis ◽  
Peptide Nucleic Acid ◽  
Iron Uptake ◽  
Drug Target ◽  
Uptake System ◽  
Bacteriostatic Activity ◽  
In Vivo Analysis ◽  
Antisense Peptide

Background: Neisseria meningitidis is considered as a dangerous pathogen threatening human health. Nowadays, the new drug target is focused. Toxin antitoxin (TA) system is recently identified as an antimicrobial drug target. Also, in N. meningitidis, iron-uptake system could be an interesting target for drug discovery. Methods: In this study, fbpA and mazE genes were chosen as new antimicrobial targets and treated with antisense peptide nucleic acid (PNA). Firstly, they were evaluated by bioinformatics and then analyzed by experimental procedures. Secondly, the functionality was evaluated by stress conditions. Results: Our results interestingly demonstrated that when fbpA and mazE loci of N. meningitidis were targeted by antisense PNA, 8 µM concentration of fbpA-PNA as well as 30 µM concentration of mazE-PNA inhibited the growth of N. meningitides and were found to be bacteriostatic, whereas 10 μM concentration of fbpA-PNA showed bacteriocidal activity. Conclusion: Our findings demonstrated the bactriocidal activity of fbpA-PNA and bacteriostatic activity of mazEPNA. Therefore, mazE and fbpA genes should be potent antimicrobial targets but further analysis including in vivo analysis should be performed.

Structure−Activity Relationship Study on a Simple Cationic Peptide Motif for Cellular Delivery of Antisense Peptide Nucleic Acid

2005 ◽  
Vol 48 (21) ◽  
pp. 6741-6749 ◽  
Author(s):  
Klaus Albertshofer ◽  
Andrew M. Siwkowski ◽  
Edward V. Wancewicz ◽  
Christine C. Esau ◽  
Tanya Watanabe ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Peptide Motif ◽  
Cellular Delivery ◽  
Cationic Peptide ◽  
Structure Activity ◽  
Relationship Study ◽  
Antisense Peptide
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