scholarly journals Hepatic and Skeletal Muscle Adiposity Are Associated with Diabetes Independent of Visceral Adiposity in Nonobese African-Caribbean Men

2020 ◽  
Vol 18 (6) ◽  
pp. 275-283
Author(s):  
Iva Miljkovic ◽  
Allison L. Kuipers ◽  
Ryan K. Cvejkus ◽  
J. Jeffrey Carr ◽  
James G. Terry ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Visceral Adiposity ◽  
African Caribbean ◽  
Muscle Adiposity

Abstract P070: Longer Sleep Duration Is Associated With Less Myosteatosis In African Caribbean Adults

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Adrianna I Acevedo-Fontanez ◽  
Ryan Cvejkus ◽  
Allison L Kuipers ◽  
Joseph Zmuda ◽  
Victor Wheeler ◽  
...  
Keyword(s):  
Physical Activity ◽  
Skeletal Muscle ◽  
Sleep Duration ◽  
Vigorous Physical Activity ◽  
Health Study ◽  
Muscle Area ◽  
Subjective Data ◽  
Muscle Density ◽  
Intermuscular Adipose Tissue ◽  
African Caribbean

Introduction: Skeletal muscle is the largest organ in the human body and vital to maintaining metabolic homeostasis. Increased skeletal muscle fat infiltration (i.e. myosteatosis) is now recognized as a major risk factor for cardio-metabolic diseases, independent of general obesity. Modifications in lifestyle, such as sleep, to reduce myosteatosis would be of great public health importance. However, studies of this relationship often use subjective data and are lacking in minority populations. The aim of this study was to examine the relation between objectively measured sleep duration and myosteatosis at the calf among African Caribbeans. Methods: Data were collected on men (n=393) and women (n=438) from the Tobago Health Study. Sleep duration and physical activity was collected using a SenseWear Pro Armband (BodyMedia, Inc.). Participants were instructed to wear the armband at all times, except in water, for 4-7 days. Measures of muscle density, intermuscular adipose tissue (IMAT), and area were obtained by peripheral QCT scans of the calf (Stratec XCT-2000). Model covariates included age, sex, BMI, diabetes, alcohol intake, smoking, and moderate to vigorous physical activity (MVPA). Linear regression was used to assess the relationship of sleep duration on skeletal muscle. Results: Mean sleep duration was 5.5 hours/day (Min 2.2, Max 11.6). Overall, participants were aged 58.7 years, had a BMI of 30.2 kg/m 2 , spent an average of 42 min/day in MVPA, and 18% were diabetic. In fully adjusted models, longer sleep duration was associated with smaller muscle area, but greater muscle density and less IMAT (all P<0.03). There was no interaction of sleep and sex on muscle density, area and IMAT (p-value=0.5184; 0.2730; 0.0954). Conclusions: In African Caribbean men and women, longer sleep duration was associated with less myosteatosis, as well as, less muscle area at the calf. Further research is warranted to understand this relationship longitudinally in order to determine how it may inform lifestyle guidelines in the Caribbean.

scholarly journals Markers of Inflammation Are Heritable and Associated with Subcutaneous and Ectopic Skeletal Muscle Adiposity in African Ancestry Families

2011 ◽  
Vol 9 (4) ◽  
pp. 319-326 ◽  
Author(s):  
Iva Miljkovic ◽  
Allison L. Kuipers ◽  
Candace M. Kammerer ◽  
Xiaojing Wang ◽  
Clareann H. Bunker ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
African Ancestry ◽  
Markers Of Inflammation ◽  
Muscle Adiposity

Impact of Skeletal Muscle Mass, Muscle Quality, and Visceral Adiposity on Outcomes Following Resection of Intrahepatic Cholangiocarcinoma

2016 ◽  
Vol 24 (4) ◽  
pp. 1037-1045 ◽  
Author(s):  
Shinya Okumura ◽  
Toshimi Kaido ◽  
Yuhei Hamaguchi ◽  
Atsushi Kobayashi ◽  
Hisaya Shirai ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Intrahepatic Cholangiocarcinoma ◽  
Skeletal Muscle Mass ◽  
Visceral Adiposity ◽  
Muscle Quality

scholarly journals Skeletal muscle adiposity is associated with serum lipid and lipoprotein levels in Afro-Caribbean men

Obesity ◽  
2013 ◽  
Vol 21 (9) ◽  
pp. 1900-1907 ◽  
Author(s):  
I. Miljkovic ◽  
A.L. Kuipers ◽  
L.H. Kuller ◽  
Y. Sheu ◽  
C.H. Bunker ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Serum Lipid ◽  
Muscle Adiposity

Wnt Pathway Inhibitor DKK1—A Potential Novel Biomarker for Ectopic Skeletal Muscle Adiposity

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2100-P
Author(s):  
HIRA ALI ◽  
JOSEPH M. ZMUDA ◽  
RYAN CVEJKUS ◽  
ERIN E. KERSHAW ◽  
ALLISON L. KUIPERS ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Wnt Pathway ◽  
Muscle Adiposity

scholarly journals Skeletal muscle adiposity is associated with physical activity, exercise capacity and fibre shift in COPD

2014 ◽  
Vol 44 (5) ◽  
pp. 1188-1198 ◽  
Author(s):  
Matthew Maddocks ◽  
Dinesh Shrikrishna ◽  
Simone Vitoriano ◽  
Samantha A. Natanek ◽  
Rebecca J. Tanner ◽  
...  
Keyword(s):  
Physical Activity ◽  
Computed Tomography ◽  
Skeletal Muscle ◽  
Exercise Capacity ◽  
Intramuscular Fat ◽  
Cross Sectional Area ◽  
Sectional Area ◽  
Cross Sectional ◽  
Muscle Attenuation ◽  
Muscle Adiposity

Quadriceps muscle phenotype varies widely between patients with chronic obstructive pulmonary disease (COPD) and cannot be determined without muscle biopsy. We hypothesised that measures of skeletal muscle adiposity could provide noninvasive biomarkers of muscle quality in this population.In 101 patients and 10 age-matched healthy controls, mid-thigh cross-sectional area, percentage intramuscular fat and skeletal muscle attenuation were calculated using computed tomography images and standard tissue attenuation ranges: fat -190– -30 HU; skeletal muscle -29–150 HU.Mean±sdpercentage intramuscular fat was higher in the patient group (6.7±3.5%versus4.3±1.2%, p = 0.03). Both percentage intramuscular fat and skeletal muscle attenuation were associated with physical activity level, exercise capacity and type I fibre proportion, independent of age, mid-thigh cross-sectional area and quadriceps strength. Combined with transfer factor of the lung for carbon monoxide, these variables could identify >80% of patients with fibre type shift with >65% specificity (area under the curve 0.83, 95% CI 0.72–0.95).Skeletal muscle adiposity assessed by computed tomography reflects multiple aspects of COPD related muscle dysfunction and may help to identify patients for trials of interventions targeted at specific muscle phenotypes.

Abstract MP048: Ectopic Muscle and Liver Adiposity are Independently Associated with Type 2 Diabetes in African Ancestry Men

Circulation ◽  
2017 ◽  
Vol 135 (suppl_1) ◽  
Author(s):  
Iva Miljkovic ◽  
Allison Kuipers ◽  
J Jeffrey Carr ◽  
James Terry ◽  
Sangeeta Nair ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Body Fat ◽  
African Ancestry ◽  
Ectopic Fat ◽  
Fat Depots ◽  
Total Body Fat ◽  
Muscle Adiposity ◽  
Total Body

Although obesity is a major driver of type 2 diabetes (T2D), many obese individuals do not develop T2D. Indeed, fat around and within non-adipose tissue organs (i.e., ectopic fat) is emerging as a strong risk factor for diabetes. The potential differential contribution of ectopic fat depots throughout the body on T2D risk is unclear because studies have mainly focused on visceral and/or liver fat. No study, to our knowledge, has addressed the potential independent association of visceral, liver, and skeletal muscle adiposity with T2D. Such studies are particularly needed among African ancestry populations, as generalized obesity and other risk factors do not appear to explain the high T2D burden in this population segment. To address this knowledge gap, we measured total body fat by DXA, and visceral, liver, and calf skeletal muscle adiposity by computed tomography in 490 Afro-Caribbean men, aged 50-91 years (mean age=64 years, mean BMI=27.5 kg/m 2 ). The prevalence of T2D in this population was 22.3%. We employed multiple logistic regression using total body fat percent and ectopic fat depots as predictors (Table). We found that each 7.9 HU decrease in liver attenuation (indicative of greater liver adiposity) was associated with a 33% increased odds of T2D (p=0.011). Similarly, each 4.2 mg/cm 3 decrease in muscle attenuation (indicative of greater intra-muscular adiposity) was associated with a 31% increased odds of T2D (p=0.04). These associations were independent of total and visceral adiposity. Our results support the “ectopic fat syndrome” theory, as opposed to the “portal theory”, in the pathogenesis of diabetes among African ancestry men. Longitudinal studies are needed to clarify the exact role of specific ectopic fat depots in T2D, particularly in high-risk African ancestry populations.

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