scholarly journals Relationship of Circulating miRNAs with Insulin Sensitivity and Associated Metabolic Risk Factors in Humans

2018 ◽  
Vol 16 (2) ◽  
pp. 82-89 ◽  
Author(s):  
Elizabeth Ma ◽  
Yuchang Fu ◽  
W. Timothy Garvey
2010 ◽  
Vol 40 (6) ◽  
pp. 527-533 ◽  
Author(s):  
Akiko Tamakoshi ◽  
Koji Suzuki ◽  
Yingsong Lin ◽  
Yoshinori Ito ◽  
Kiyoko Yagyu ◽  
...  

2013 ◽  
Vol 9 (1) ◽  
pp. 43-52 ◽  
Author(s):  
J. Warolin ◽  
K. R. Coenen ◽  
J. L. Kantor ◽  
L. E. Whitaker ◽  
L. Wang ◽  
...  

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e108421 ◽  
Author(s):  
Ved Prakash Meena ◽  
V. Seenu ◽  
M. C. Sharma ◽  
Saumya Ranjan Mallick ◽  
Ashu Seith Bhalla ◽  
...  

2008 ◽  
Vol 101 (6) ◽  
pp. 886-894 ◽  
Author(s):  
A. Louise Brown ◽  
Joan Lane ◽  
Jacqueline Coverly ◽  
Janice Stocks ◽  
Sarah Jackson ◽  
...  

Animal evidence indicates that green tea may modulate insulin sensitivity, with epigallocatechin-3-gallate (EGCG) proposed as a likely health-promoting component. The purpose of this study was to investigate the effect of dietary supplementation with EGCG on insulin resistance and associated metabolic risk factors in man. Overweight or obese male subjects, aged 40–65 years, were randomly assigned to take 400 mg capsules of EGCG (n 46) or the placebo lactose (n 42), twice daily for 8 weeks. Oral glucose tolerance testing and measurement of metabolic risk factors (BMI, waist circumference, percentage body fat, blood pressure, total cholesterol, LDL-cholesterol, HDL-cholesterol, TAG) was conducted pre- and post-intervention. Mood was evaluated weekly using the University of Wales Institute of Science and Technology mood adjective checklist. EGCG treatment had no effect on insulin sensitivity, insulin secretion or glucose tolerance but did reduce diastolic blood pressure (mean change: placebo − 0·058 (se 0·75) mmHg; EGCG − 2·68 (se 0·72) mmHg; P = 0·014). No significant change in the other metabolic risk factors was observed. The EGCG group also reported feeling in a more positive mood than the placebo group across the intervention period (mean score for hedonic tone: EGCG, 29·11 (se 0·44); placebo, 27·84 (se 0·46); P = 0·048). In conclusion, regular intake of EGCG had no effect on insulin resistance but did result in a modest reduction in diastolic blood pressure. This antihypertensive effect may contribute to some of the cardiovascular benefits associated with habitual green tea consumption. EGCG treatment also had a positive effect on mood. Further studies are needed to confirm the findings and investigate their mechanistic basis.


Work ◽  
2021 ◽  
pp. 1-9
Author(s):  
Michael K. Lemke ◽  
Douglas J Oberlin ◽  
Yorghos Apostolopoulos ◽  
Adam Hege ◽  
Sevil Sönmez ◽  
...  

BACKGROUND: Long-haul truck drivers are disproportionately exposed to metabolic risk; however, little is known about their metabolic health and the role of physical activity and other risk factors in metabolic outcomes. OBJECTIVE: This study compares truck drivers’ insulin sensitivity, and associations between metabolic risk factors and insulin sensitivity, with those of the general population. METHODS: Survey, anthropometric, and biometric data were collected from 115 long-haul truckers, which were then compared to the general population data using the National Health and Nutrition Examination Survey (NHANES) dataset. The quantitative insulin sensitivity check index (QUICKI) was used to estimate insulin sensitivity. RESULTS: Truck drivers had lower QUICKI scores than the general population cohort. Sagittal abdominal diameter and exercise were predictive for QUICKI among combined cohorts. Waist circumference and perceived health were more predictive for QUICKI among truck drivers, and sagittal abdominal diameter and income were more predictive for QUICKI among the general population. CONCLUSIONS: Long-haul truckers appear to represent a subset of the general population regarding the impact of physical activity and other metabolic risk factors on QUICKI. Accordingly, comprehensive efforts which target these factors are needed to improve truckers’ physical activity levels and other metabolic risks.


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