Daily Coffee Intake Inhibits Pancreatic Beta Cell Damage and Nonalcoholic Steatohepatitis in a Mouse Model of Spontaneous Metabolic Syndrome, Tsumura-Suzuki Obese Diabetic Mice

2017 ◽  
Vol 15 (4) ◽  
pp. 170-177 ◽  
Author(s):  
Syunsuke Watanabe ◽  
Tetsuyuki Takahashi ◽  
Hirohisa Ogawa ◽  
Hisanori Uehara ◽  
Takaaki Tsunematsu ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Mouse Model ◽  
Beta Cell ◽  
Nonalcoholic Steatohepatitis ◽  
Cell Damage ◽  
Pancreatic Beta Cell ◽  
Diabetic Mice ◽  
Coffee Intake ◽  
Beta Cell Damage

scholarly journals Psoralea corylifoliaL. Seed Extract Ameliorates Streptozotocin-Induced Diabetes in Mice by Inhibition of Oxidative Stress

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Eunhui Seo ◽  
Eun-Kyu Lee ◽  
Cheol Soon Lee ◽  
Kwang-Hoon Chun ◽  
Mi-Young Lee ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Beta Cell ◽  
Cell Damage ◽  
Serum Insulin ◽  
Pancreatic Beta Cell ◽  
Beta Cell Death ◽  
Streptozotocin Induced Diabetes ◽  
Induced Apoptosis ◽  
Beta Cell Damage

Pancreatic beta-cell death is known to be the cause of deficient insulin production in diabetes mellitus. Oxidative stress is one of the major causes of beta-cell death. In this study, we investigated the effects ofPsoralea corylifoliaL. seed (PCS) extract on beta-cell death. Oral administration of PCS extract resulted in a significant improvement of hyperglycemia in streptozotocin-induced diabetic mice. PCS extract treatment improved glucose tolerance and increased serum insulin levels. To study the mechanisms involved, we investigated the effects of PCS extract on H2O2-induced apoptosis in INS-1 cells. Treatment with PCS extract inhibited cell death. PCS extract treatment decreased reactive oxygen species level and activated antioxidative enzymes. Among the major components of PCS extract, psoralen and isopsoralen (coumarins), but not bakuchiol, showed preventive effects against H2O2-induced beta-cell death. These findings indicate that PCS extract may be a potential pharmacological agent to protect against pancreatic beta-cell damage caused by oxidative stress associated with diabetes.

EX4 stabilizes and activates Nrf2 via PKCδ, contributing to the prevention of oxidative stress-induced pancreatic beta cell damage

2017 ◽  
Vol 315 ◽  
pp. 60-69 ◽  
Author(s):  
Mi-Hwi Kim ◽  
Eung-Hwi Kim ◽  
Hye Seung Jung ◽  
Dongki Yang ◽  
Eun-Young Park ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Beta Cell ◽  
Cell Damage ◽  
Pancreatic Beta Cell ◽  
Beta Cell Damage

scholarly journals Protection of silver nanoparticles using Eysenhardtia polystachya in peroxide-induced pancreatic β-Cell damage and their antidiabetic properties in zebrafish

2018 ◽  
Vol Volume 13 ◽  
pp. 2601-2612 ◽  
Author(s):  
Abraham Heriberto Garcia Campoy ◽  
Rosa Martha Pérez Gutiérrez ◽  
Gabriela Manriquez-Alvirde ◽  
Alethia Muñiz Ramirez
Keyword(s):  
Silver Nanoparticles ◽  
Beta Cell ◽  
Cell Damage ◽  
Pancreatic Beta Cell ◽  
Beta Cell Damage

780-P: Improved Mitochondrial Function by Luseogliflozin Prevents Pancreatic Beta-Cell Damage

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 780-P
Author(s):  
YUKI YAMAUCHI ◽  
AKINOBU NAKAMURA ◽  
TAKASHI YOKOTA ◽  
KIYOHIKO TAKAHASHI ◽  
SHINICHIRO KAWATA ◽  
...  
Keyword(s):  
Beta Cell ◽  
Mitochondrial Function ◽  
Cell Damage ◽  
Pancreatic Beta Cell ◽  
Beta Cell Damage

scholarly journals ZnT8 antibodies in patients with cystic fibrosis: An expression of secondary beta-cell damage?

2013 ◽  
Vol 12 (6) ◽  
pp. 803-805 ◽  
Author(s):  
Carla Bizzarri ◽  
Germana Giannone ◽  
Danila Benevento ◽  
Enza Montemitro ◽  
Federico Alghisi ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Beta Cell ◽  
Cell Damage ◽  
Beta Cell Damage
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