Anti-Androgenic Activity of Nardostachys jatamansi DC and Tribulus terrestris L. and Their Beneficial Effects on Polycystic Ovary Syndrome–Induced Rat Models

2015 ◽  
Vol 13 (6) ◽  
pp. 248-254 ◽  
Author(s):  
Palakkil Mavilavalappil Sandeep ◽  
Toine F.H. Bovee ◽  
Krishnan Sreejith
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Tribulus Terrestris ◽  
Ovary Syndrome ◽  
Rat Models ◽  
Beneficial Effects ◽  
Androgenic Activity ◽  
Nardostachys Jatamansi

scholarly journals Effects of dodder total flavone on polycystic ovary syndrome rat models induced by DHEA combined HCG

2019 ◽  
Vol 26 (4) ◽  
pp. 821-827 ◽  
Author(s):  
Mingsan Miao ◽  
Mengfan Peng ◽  
Zhengwang Zhu ◽  
Xiaoli Yan ◽  
Zhenzhen Wei ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Rat Models

scholarly journals The Effects of Oral Isotretinoin in Women with Acne and Polycystic Ovary Syndrome

2019 ◽  
Vol 2019 ◽  
pp. 1-5 ◽  
Author(s):  
G. Acmaz ◽  
L. Cınar ◽  
B. Acmaz ◽  
H. Aksoy ◽  
Yusuf Taner Kafadar ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Venous Blood ◽  
Insulin Level ◽  
Free Testosterone ◽  
Ovary Syndrome ◽  
Heavy Smoking ◽  
Oral Contraceptive Pills ◽  
Beneficial Effects ◽  
Oral Isotretinoin

Introduction. Many patients who were diagnosed as polycystic ovary syndrome- (PCOS-) related acne were not capable of sustaining or beginning oral contraceptive pills (OCPs) due to pill scaring, contraindications of OCP use, migraine, or smoking. In this situation, oral isotretinoin treatment may become an important option for PCOS-related acne. The aim of the study was to determine the effects of isotretinoin treatment on PCOS patients who were complicated with severe cystic acne. Materials and Methods. This study consisted of 40 female patients diagnosed as PCOS complicated with severe cystic acne. These patients were not eligible candidates for OCP use due to migraine, thrombophilia, heavy smoking, or pill scare. To establish baseline values of hormone levels, on days 2–5 of the menstrual cycle, venous blood samples were obtained. Moreover Modified Ferriman-Gallwey (mFG) score, acne score (AS), follicle count, and bilateral ovarian volumes were evaluated both before and after isotretinoin treatment. Results. Isotretinoin treatment significantly decreased Ferriman-Gallwey score, free testosterone, insulin level, hemoglobin level, acne score, and ovarian volume. Increased triglyceride and cholesterol levels were detected after treatment. Conclusion. Isotretinoin treatment may have beneficial effects on free testosterone, insulin, acne score, and Ferriman-Gallwey score. Solely isotretinoin administration may supply adequate healing in PCOS patients’ symptoms complicated with severe cystic acne who is not eligible candidates for OCP use. This trial is registered with Clinicaltrials.gov NCT02855138.

scholarly journals Effect of Aslagh Capsule, a Traditional Compound Herbal Product on Oligomenorrhea in Patients with Polycystic Ovary Syndrome: A Three-Arm, Open-label, Randomized, Controlled Trial

2019 ◽  
Vol 8 ◽  
pp. 1261
Author(s):  
Maryam Bahman ◽  
Homa Hajimehdipoor ◽  
Soodabeh Bioos ◽  
Fataneh Hashem-Dabaghian ◽  
Maryam Afrakhteh ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Controlled Trial ◽  
Herbal Product ◽  
The Other ◽  
Menstrual Bleeding ◽  
Open Label ◽  
Ovary Syndrome ◽  
Beneficial Effects ◽  
Significant Difference

Background: Oligomenorrhea is a common complaint in patients with polycystic ovary syndrome (PCOS). There are some useful medicinal recommendations such as Aslagh product (include fennel fruits, carrot seeds, chaste tree fruits) in Iranian traditional medicine for the treatment of oligomenorrhea in PCOS. Hence, the present investigation was designed to compare Aslagh capsule with metformin on the oligomenorrhea. Materials and Methods: One hundred fifty women aged between 18-43 years with oligomenorrhea due to PCOS were randomly divided into Aslagh, metformin, and Aslagh + metformin groups. The occurrence of menstrual bleeding was considered as the primary outcome. Menstrual cyclicity, duration, and volume of the bleeding were also evaluated. Results: Occurrence of menstrual bleeding was 87.2% in all patients, with no significant difference between the three groups (P> 0.05). Menstrual cyclicity significantly improved from baseline in Aslagh and Aslagh+ metformin groups (P=0.02). Duration of menstrual bleeding was significantly higher in Aslagh group in the first and the second menstrual bleeding cycle compared to the other two groups (P<0.05). No significant change was observed in the volume of the bleeding after the intervention in any of the three groups. The occurrence of menstrual bleeding in Aslagh group was significantly (P=0.03) higher than the other two groups in the fourth month (drug-free period). Conclusion: Aslagh capsule showed beneficial effects similar to metformin in the treatment of oligomenorrhea in PCOS women and could be suggested for use as an alternative treatment in these patients. [GMJ.2019;8:e1261]

Astragalus hamosus Acts as an Insulin Sensitizer Through the Treatment of Polycystic Ovary Syndrome Rat Models by Affecting IRS1 Expression

2021 ◽  
Vol 21 ◽  
Author(s):  
Amir Nejati ◽  
Maryam Parvini Kohneh Shahri ◽  
Tarlan Farahvash
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Reproductive Age ◽  
Ovary Syndrome ◽  
Insulin Sensitizer ◽  
Rat Models ◽  
Qrt Pcr ◽  
Pcos Group ◽  
The Impact

Background: Polycystic ovary syndrome (PCOS) is the most common endocrine abnormality among women of reproductive age. Insulin resistance is known as the hallmark of PCOS that leads to hyperinsulinemia and type 2 diabetes in PCOS patients. Objective: This study aimed to evaluate the expression pattern of IRS1 as a candidate gene in insulin resistance development in the PCOS Rat models. Methods: In this study, estradiol valerate was used for PCOS induction. Then, all of the rats were divided into five experimental groups and treated with Astragalus hamosus extract. Ethanol was used for extraction by Soxhlet, and extracts were analyzed by GC-MS. Ovarian morphology was analyzed using histological experiments. Finally, the expression of IRS1 and hormonal titration of testosterone and insulin were evaluated using qRT-PCR and ELISA assays, respectively. Results: Induction of PCOS led to an increase in body weight, which decreased after treatment with the extract. Histological assessment declared an increased number of corpus luteums in treated groups and reduced cystic follicles compared with the PCOS group. Astragalus hamosus extract-treated groups exhibited decreased levels of insulin and testosterone compared to the PCOS group. qRT-PCR results showed an increase in the expression levels of IRS1 in the treated groups compared to the PCOS group. Conclusions: This study indicated the impact of Astragalus hamosus extract on PCOS by clarifying the increased levels of IRS1 expression in the treated groups compared to the PCOS group.

Effects of Metformin and Exercise in Polycystic Ovary Syndrome: Systematic Review and Meta-Analysis

2021 ◽  
Vol 53 (11) ◽  
pp. 738-745
Author(s):  
Yu Song ◽  
Huimin Wang ◽  
Zhengyan Zhu ◽  
Hongli Huang
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Exercise Intervention ◽  
Polycystic Ovary ◽  
Meta Analysis ◽  
Reproductive Age ◽  
China National Knowledge Infrastructure ◽  
Ovary Syndrome ◽  
Menstrual Cycles ◽  
Beneficial Effects ◽  
Knowledge Infrastructure

AbstractPolycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age. Metformin is introduced for treatment of women with PCOS, and the beneficial effects of exercise in women with PCOS are found for a range of outcomes. Our aim is to compare the effects of metformin plus exercise with exercise intervention in PCOS on clinical, anthropometric, metabolic, and psychological parameters. MEDLINE, EMBASE, Web of Science and China National Knowledge Infrastructure were searched for studies. Nine studies were considered eligible for inclusion. The meta-analysis reveals that metformin offers additive benefits to exercise, leading to modest improvements in menstrual cycles, hyperandrogenism, and abdominal fat.

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