Association of Monocyte Chemoattractant Protein-1 −2518 Polymorphism With Metabolic Syndrome in a South Indian Cohort

2009 ◽  
Vol 7 (3) ◽  
pp. 193-198 ◽  
Author(s):  
Savneet Kaur ◽  
Sumith R. Panicker ◽  
T. James ◽  
P. Sankara Sarma ◽  
K.R. Thankappan ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein ◽  
South Indian

scholarly journals Gene variants of monocyte chemoattractant protein 1 and components of metabolic syndrome in KORA S4, Augsburg

2007 ◽  
Vol 156 (3) ◽  
pp. 377-385 ◽  
Author(s):  
Eva-Maria Sedlmeier ◽  
Harald Grallert ◽  
Cornelia Huth ◽  
Hannelore Löwel ◽  
Christian Herder ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
Multiple Testing ◽  
Population Based ◽  
Nucleotide Polymorphisms ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein ◽  
New Finding

Objective: Monocyte chemoattractant protein 1 (MCP-1) has been suggested to be involved in the development of several components of metabolic syndrome (MetS). The present study investigated the association of nine MCP-1 single nucleotide polymorphisms (SNPs) with MetS, type 2 diabetes mellitus and metabolic risk factors. Subjects and methods: The population-based study sample comprised 1630 subjects aged 55–74 years from KORA S4 (Cooperative Health Research in the Region of Augsburg Survey 4). Genotyping was carried out by matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) analysis of allele-dependent primer extension products. Results: The MCP-1 SNP c.-3813C>T exhibited trends for differences between the genotype groups in triglycerides, 2-h glucose and uric acid (P = 0.0084, 0.014, 0.027). Other trends were observed for c.-928G>C associated with height and fasting glucose (P = 0.0024, 0.033), for c.105T>C with height and leukocytes (P = 0.0095, 0.047), for c.*65C>T and c.*3879C>T with MCP-1 levels (both P = 0.012) and for c.-2138A>T with interleukin-6 levels. After correction for multiple testing, none of the analysed SNPs, except c.-928G>C in men showed a significant association with MetS, T2DM or other analysed parameters. Haplotype MCP-1*1 and c.-928G>C in men (P = 0.0002, 0.0004) were significantly associated with an increase in height. Conclusions: This is the first study to investigate the associations of MCP-1 SNPs with MetS. We found trends for several components of MetS. These parameters were hyperlipidaemia, fasting and 2-h glucose, and uric acid. A new finding is that MCP-1*1 haplotype is associated with height. Further investigation in larger populations is needed to clarify the involvement of MCP-1 in MetS.

Weight loss reduces serum monocyte chemoattractant protein-1 concentrations in association with improvements in renal injury in obese men with metabolic syndrome

2015 ◽  
Vol 53 (4) ◽  
Author(s):  
Chia-Po Fu ◽  
Wayne H.-H. Sheu ◽  
I.-Te Lee ◽  
Wen-Jane Lee ◽  
Jun-Sing Wang ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Weight Loss ◽  
Renal Injury ◽  
Exercise Intervention ◽  
Linear Regression Analysis ◽  
Weight Loss Program ◽  
Obese People ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein

AbstractMonocyte chemoattractant protein-1 (MCP-1) is involved in obesity-related renal injury. The aim of the present study was to examine the effects of weight loss on changes in MCP-1 and markers of renal injury, specifically serum cystatin C (S-CysC) and urinary N-acetyl glucosaminidase (UNAG), in obese people.In this prospective study, 40 obese men with metabolic syndrome (MetS) participated in a 3-month dietary and exercise intervention. Twenty-eight subjects completed the study with a ≥5% weight loss. Circulating MCP-1, S-CysC and UNAG to creatinine ratio (UNCR) were determined before and after the weight loss program.Obesity-associated components of MetS demonstrated significant improvements after the weight loss program. In addition, at baseline, circulating MCP-1 concentrations were positively correlated with UNCR and S-CysC levels. After weight loss, blood MCP-1 and UNCR levels were significantly decreased, but S-CysC was not affected. Using multiple linear regression analysis, there was a significant relationship between changes in UNCR and MCP-1 after adjusting for other potential confounding factors.Weight loss may improve renal tubular injury by ameliorating obesity-related inflammation in obese men with MetS.

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