The Global Prevalence of Class 1 Integron and Associated Antibiotic Resistance in Escherichia coli from Patients with Urinary Tract Infections, a Systematic Review and Meta-Analysis

2020 ◽  
Vol 26 (10) ◽  
pp. 1208-1218 ◽  
Author(s):  
Mehrdad Halaji ◽  
Awat Feizi ◽  
Arezoo Mirzaei ◽  
Hadi Sedigh Ebrahim-Saraie ◽  
Amirhossein Fayyazi ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Systematic Review ◽  
Antibiotic Resistance ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Meta Analysis ◽  
Class 1 Integron ◽  
Global Prevalence ◽  
Class 1 ◽  
Tract Infections

scholarly journals Frequency of Class 1 Integron in Escherichia Coli Strains Isolated from Patients with Urinary Tract Infections in North of Iran

2015 ◽  
Vol 27 (1) ◽  
pp. 10 ◽  
Author(s):  
Fatemeh Ahangarkani ◽  
Ramazan Rajabnia ◽  
Elaheh Shahandashti ◽  
Meghdad Bagheri ◽  
Maryam Ramez
Keyword(s):  
Escherichia Coli ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Class 1 Integron ◽  
Class 1 ◽  
North Of Iran ◽  
Tract Infections

scholarly journals Virulence factors and antimicrobial resistance of uropathogenic Escherichia coli (UPEC) isolated from urinary tract infections: A systematic review and meta-analysis

2021 ◽  
Author(s):  
Gabriel Kambale Bunduki ◽  
Eva Heinz ◽  
Vincent Samuel Phiri ◽  
Patrick Noah ◽  
Nicholas Feasey ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Systematic Review ◽  
Urinary Tract ◽  
Antimicrobial Resistance ◽  
Virulence Factors ◽  
Urinary Tract Infections ◽  
Meta Analysis ◽  
Analysis Model ◽  
Beta Lactams ◽  
Tract Infections

Abstract Background Uropathogenic Escherichia coli (UPEC) are amongst the most frequent causes of urinary tract infections. We report a systematic review and meta-analysis of virulence factors and antimicrobial resistance of UPEC isolated from urinary tract infections. Methods A systematic review and meta-analysis were performed using PRISMA guidelines (Research Registry ref 5874). Data were extracted from PubMed/MEDLINE and ScienceDirect databases for studies published from January 1, 2000 to December 31, 2019. Studies reporting antimicrobial resistance and virulence factors of UPEC isolated in confirmed urinary tract infections (≥ 105CFU/ml) were eligible. Prevalence of antimicrobial resistance and virulence factors of UPEC were estimated using random-effects meta-analysis model. Estimates with 95% confidence intervals, I-square (I2) statistic, and Cochran’s Q test were computed using the score statistic and the exact binomial method by incorporating the Freeman-Tukey double arcsine transformation of proportions. Results Our search returned 2,504 hits, of which 13 studies were included in the meta-analysis, totalling 1,888 UPEC isolates. Highest antimicrobial resistance rates were observed among the antibiotic class of tetracycline in 69.1% (498/721), followed by sulphonamides in 59.3% (1119/1888), quinolones in 49.4% (1956/3956), and beta-lactams in 36.9% (4410/11964). Among beta-lactams, high resistance was observed in aminopenicillins in 74.3% (1157/1557) and first generation cephalosporins in 38.8% (370/953). Meanwhile, virulence factors with highest prevalence were immune suppressors (54.1%) followed by adhesins (45.9%). Taken individually, the most observed virulence genes were shiA (92.1%), CSH (80.0%), fimH/MSHA (75.3%), traT (75.1%), sisA (72.2%), iucD (65.7%), iutA (61.8%), kpsMTII (60.6%), and PAI (55.2%). Conclusions The increased antibiotic resistance of UPEC isolates was demonstrated and suggested a need for reassessment of empirical therapies in urinary tract infections treatment caused by this pathogen. In addition, this pathotype exhibited diverse surface and secreted virulence factors.

scholarly journals Virulence factors and antimicrobial resistance of uropathogenic Escherichia coli (UPEC) isolated from urinary tract infections: a systematic review and meta-analysis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Gabriel Kambale Bunduki ◽  
Eva Heinz ◽  
Vincent Samuel Phiri ◽  
Patrick Noah ◽  
Nicholas Feasey ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Systematic Review ◽  
Urinary Tract ◽  
Antimicrobial Resistance ◽  
Virulence Factors ◽  
Urinary Tract Infections ◽  
Meta Analysis ◽  
Analysis Model ◽  
Beta Lactams ◽  
Tract Infections

Abstract Background Uropathogenic Escherichia coli (UPEC) are amongst the most frequent causes of urinary tract infections. We report a systematic review and meta-analysis of virulence factors and antimicrobial resistance of UPEC isolated from urinary tract infections. Methods A systematic review and meta-analysis were performed using PRISMA guidelines (Research Registry ref. 5874). Data were extracted from PubMed/MEDLINE and ScienceDirect databases for studies published from January 1, 2000 to December 31, 2019. Studies reporting antimicrobial resistance and virulence factors of UPEC isolated in confirmed urinary tract infections (≥105CFU/ml) were eligible. Prevalence of antimicrobial resistance and virulence factors of UPEC were estimated using random-effects meta-analysis model. Estimates with 95% confidence intervals, I-square (I2) statistic, and Cochran’s Q test were computed using the score statistic and the exact binomial method by incorporating the Freeman-Tukey double arcsine transformation of proportions. Results Our search returned 2504 hits, of which 13 studies were included in the meta-analysis, totalling 1888 UPEC isolates. Highest antimicrobial resistance rates were observed among the antibiotic class of tetracycline in 69.1% (498/721), followed by sulphonamides in 59.3% (1119/1888), quinolones in 49.4% (1956/3956), and beta-lactams in 36.9% (4410/11964). Among beta-lactams, high resistance was observed in aminopenicillins in 74.3% (1157/1557) and first generation cephalosporins in 38.8% (370/953). Meanwhile, virulence factors with highest prevalence were immune suppressors (54.1%) followed by adhesins (45.9%). Taken individually, the most observed virulence genes were shiA (92.1%), CSH (80.0%), fimH/MSHA (75.3%), traT (75.1%), sisA (72.2%), iucD (65.7%), iutA (61.8%), kpsMTII (60.6%), and PAI (55.2%). Conclusions The increased antibiotic resistance of UPEC isolates was demonstrated and suggested a need for reassessment of empirical therapies in urinary tract infections treatment caused by this pathogen. In addition, this pathotype exhibited diverse surface and secreted virulence factors.

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