Bloodstream Infections due to Carbapenem-Resistant Klebsiella pneumoniae: A Single-Center Retrospective Study on Risk Factors and Therapy Options

2020 ◽  
Author(s):  
Lisha Shen ◽  
Chan Lian ◽  
Bingquan Zhu ◽  
Yake Yao ◽  
Qing Yang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Retrospective Study ◽  
Klebsiella Pneumoniae ◽  
Bloodstream Infections ◽  
Single Center ◽  
Therapy Options ◽  
Carbapenem Resistant

Disease Severity Is an Independent Risk Factor of Mortality and Outcomes in Critically Ill Patients With Carbapenem-resistant Klebsiella Pneumoniae Bloodstream Infections: a 5-year Retrospective Analysis

2021 ◽  
Author(s):  
Yuzhen Qiu ◽  
Wen Xu ◽  
Yunqi Dai ◽  
Ruoming Tan ◽  
Jialin Liu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Septic Shock ◽  
Klebsiella Pneumoniae ◽  
Critically Ill Patients ◽  
Bloodstream Infections ◽  
Polymyxin B ◽  
Mortality Rates ◽  
Carbapenem Resistant ◽  
All Cause Mortality ◽  
Independent Risk Factors

Abstract Background: Carbapenem-resistant Klebsiella pneumoniae bloodstream infections (CRKP-BSIs) are associated with high morbidity and mortality rates, especially in critically ill patients. Comprehensive mortality risk analyses and therapeutic assessment in real-world practice are beneficial to guide individual treatment.Methods: We retrospectively analyzed 87 patients with CRKP-BSIs (between July 2016 and June 2020) to identify the independent risk factors for 28-day all-cause mortality. The therapeutic efficacies of tigecycline-and polymyxin B-based therapies were analyzed.Results: The 28-day all-cause mortality and in-hospital mortality rates were 52.87% and 67.82%, respectively, arising predominantly from intra-abdominal (56.32%) and respiratory tract infections (21.84%). A multivariate analysis showed that 28-day all-cause mortality was independently associated with the patient’s APACHE II score (p = 0.002) and presence of septic shock at BSI onset (p = 0.006). All-cause mortality was not significantly different between patients receiving tigecycline- or polymyxin B-based therapy (55.81% vs. 53.85%, p = 0.873), and between subgroups mortality rates were also similar. Conclusions: Critical illness indicators (APACHE II scores and presence of septic shock at BSI onset) were independent risk factors for 28-day all-cause mortality. There was no significant difference between tigecycline- and polymyxin B-based therapy outcomes. Prompt and appropriate infection control should be implemented to prevent CRKP infections.

scholarly journals Epidemiology and risk factors for mortality in bloodstream infections: A single-center retrospective study in Japan

2018 ◽  
Vol 46 (12) ◽  
pp. e75-e79 ◽  
Author(s):  
Haruka Hattori ◽  
Masayuki Maeda ◽  
Yasuhiro Nagatomo ◽  
Takahiro Takuma ◽  
Yoshihito Niki ◽  
...  
Keyword(s):  
Risk Factors ◽  
Retrospective Study ◽  
Bloodstream Infections ◽  
Single Center

scholarly journals Risk Factors for Carbapenem-Resistant Klebsiella pneumoniae Bloodstream Infections and Outcomes

2020 ◽  
Vol Volume 13 ◽  
pp. 207-215
Author(s):  
Youhua Yuan ◽  
Junjie Wang ◽  
Zonghui Yao ◽  
Bing Ma ◽  
Yi Li ◽  
...  
Keyword(s):  
Risk Factors ◽  
Klebsiella Pneumoniae ◽  
Bloodstream Infections ◽  
Carbapenem Resistant
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