Antibiotic Resistance, Biofilm Formation, and Intracellular Survival As Possible Determinants of Persistent or Recurrent Infections by Staphylococcus aureus in a Vietnamese Tertiary Hospital: Focus on Bacterial Response to Moxifloxacin

2020 ◽  
Vol 26 (6) ◽  
pp. 537-544 ◽  
Author(s):  
Tiep Khac Nguyen ◽  
Maria A. Argudín ◽  
Ariane Deplano ◽  
Pham Hong Nhung ◽  
Hoang Anh Nguyen ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antibiotic Resistance ◽  
Biofilm Formation ◽  
Intracellular Survival ◽  
Tertiary Hospital ◽  
Recurrent Infections ◽  
Bacterial Response

Investigation of the antibiotic resistance and biofilm formation of Staphylococcus aureus strains isolated from gangrenous mastitis of ewes

2012 ◽  
Vol 60 (2) ◽  
pp. 189-197 ◽  
Author(s):  
Osman Tel ◽  
Özkan Aslantaş ◽  
Oktay Keskin ◽  
Ebru Yilmaz ◽  
Cemil Demir
Keyword(s):  
Staphylococcus Aureus ◽  
Antibiotic Resistance ◽  
Virulence Factor ◽  
Resistance Genes ◽  
Biofilm Formation ◽  
Antibiotic Resistance Genes ◽  
Penicillin G ◽  
Beta Lactamase ◽  
Potential Virulence Factor ◽  
Amoxicillin Clavulanic Acid

In this study,Staphylococcus aureusstrains (n = 110) isolated from seven ewe flocks in Sanliurfa, Turkey were screened for antibiotic resistance and biofilmforming ability as well as for genes associated with antibiotic resistance and biofilm-forming ability. All isolates were found to be susceptible to oxacillin, gentamicin, clindamycin, cefoxitin, tetracycline, vancomycin, amoxicillin-clavulanic acid, ciprofloxacin and sulphamethoxazole-trimethoprim. The percent proportions of strains resistant to penicillin G, ampicillin and erythromycin were 27.2% (n = 30), 25.4% (n = 28) and 6.3% (n = 7), respectively. Regarding the antibiotic resistance genes, 32 (29%) isolates carried theblaZ and 8 (7.2%) theermC gene. Other resistance genes were not detected in the isolates. All isolates showed biofilm-forming ability on Congo red agar (CRA), while 108 (98.18%) and 101 (91.81%) of them were identified as biofilm producers by the use of standard tube (ST) and microplate (MP) methods, respectively. All isolates carried theicaA andicaD genes but none of them harboured thebapgene. The results demonstrated thatS. aureusisolates from gangrenous mastitis were mainly resistant to penicillins (which are susceptible to the staphylococcal beta-lactamase enzyme), and less frequently to erythromycin. Furthermore, all of theS. aureusisolates produced biofilm which was considered a potential virulence factor in the pathogenesis of staphylococcal mastitis.

scholarly journals Cold-adapted bacterial extracts as a source of anti-infective and antimicrobial compounds against Staphylococcus aureus

2019 ◽  
Vol 14 (16) ◽  
pp. 1369-1382 ◽  
Author(s):  
Marco Artini ◽  
Rosanna Papa ◽  
Gianluca Vrenna ◽  
Concetta Lauro ◽  
Annarita Ricciardelli ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antibiotic Resistance ◽  
Marine Bacteria ◽  
Biofilm Formation ◽  
Medical Applications ◽  
Polar Regions ◽  
Antimicrobial Compounds ◽  
Cold Adapted ◽  
Organic Extracts

Aim: The dramatic emergence of antibiotic resistance has directed the interest of research toward the discovery of novel antimicrobial molecules. In this context, cold-adapted marine bacteria living in polar regions represent an untapped reservoir of biodiversity endowed with an interesting chemical repertoire. The aim of this work was to identify new antimicrobials and/or antibiofilm molecules produced by cold-adapted bacteria. Materials & methods: Organic extracts obtained from polar marine bacteria were tested against Staphylococcus aureus. Most promising samples were subjected to suitable purification strategies. Results: Results obtained led to the identification of a novel lipopeptide able to effectively inhibit the biofilm formation of S. aureus. Conclusion: New lipopeptide may be potentially useful in a wide variety of biotechnological and medical applications.

Genetic Diversity in Staphylococcus aureus and Its Relation to Biofilm Production

2021 ◽  
Author(s):  
Furqan Awan ◽  
Muhammad Muddassir Ali ◽  
Muhammad Hassan Mushtaq ◽  
Muhammad Ijaz
Keyword(s):  
Genetic Diversity ◽  
Staphylococcus Aureus ◽  
Antibiotic Resistance ◽  
Point Mutations ◽  
Economic Problem ◽  
Cellular Growth ◽  
Recurrent Infections ◽  
Biofilm Production ◽  
Variable Characteristic ◽  
Different Levels

Staphylococcus aureus (S. aureus) has been a substantial economic problem due to its antibiotic resistance, persistence inside host and recurrence of disease. It escapes from immunity because of its intra-cellular growth. Moreover, it forms biofilm on both living and in-animate surfaces that leads to recurrent infections and growth in food industry, respectively. Further, S. aureus undergoes the vertical and horizontal evolution that has genetically diversified the bacterial population. All the factors such as point mutations, plasmids, phages etc. have played their roles in diversifying this bacterium. Many bacterial physiological characteristics have been affected by genetic diversity. Biofilm forming ability is also considered as a variable characteristic of S. aureus that can help the bacteria to survive in different environments with different levels of biofilm production. In adapting the environment, S. aureus also forms different types of biofilm for its better survival. How genetic diversity is playing its role in this division of S. aureus is yet to be revealed. This chapter focuses on the factors related to genetic diversity and biofilm formation of S. aureus.

High occurrence of antibiotic resistance and biofilm-formation among Stenotrophomonas maltophilia isolated from a tertiary hospital in Southwest of Iran

Gene Reports ◽  
2020 ◽  
Vol 21 ◽  
pp. 100827 ◽  
Author(s):  
Neda Mohagheghzadeh ◽  
Zahra Hashemizadeh ◽  
Reza Khashei ◽  
Soudeh Kholdi ◽  
Samane Mohebi ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Biofilm Formation ◽  
Stenotrophomonas Maltophilia ◽  
Tertiary Hospital ◽  
High Occurrence ◽  
Southwest Of Iran
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