Performance Evaluation of MALDI-TOF MS MBT STAR-BL Versus In-House Carba NP Testing for the Rapid Detection of Carbapenemase Activity in Escherichia coli and Klebsiella pneumoniae Strains

2019 ◽  
Vol 25 (7) ◽  
pp. 985-990 ◽  
Author(s):  
Isin Akyar ◽  
Meltem Kaya Ayas ◽  
Onur Karatuna
Keyword(s):  
Escherichia Coli ◽  
Performance Evaluation ◽  
Klebsiella Pneumoniae ◽  
Rapid Detection ◽  
Maldi Tof Ms ◽  
Maldi Tof ◽  
Tof Ms

scholarly journals Rapid detection of KPC-producing Klebsiella pneumoniae in China based on MALDI-TOF MS

2021 ◽  
pp. 106385
Author(s):  
Yun Huang ◽  
Juan Li ◽  
Qianyu Wang ◽  
Kewen Tang ◽  
Congrong Li
Keyword(s):  
Klebsiella Pneumoniae ◽  
Rapid Detection ◽  
Maldi Tof Ms ◽  
Maldi Tof ◽  
Tof Ms

scholarly journals Rapid Detection of K1 Hypervirulent Klebsiella pneumoniae by MALDI-TOF MS

2015 ◽  
Vol 6 ◽  
Author(s):  
Yonglu Huang ◽  
Jiaping Li ◽  
Danxia Gu ◽  
Ying Fang ◽  
Edward W. Chan ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Rapid Detection ◽  
Maldi Tof Ms ◽  
Maldi Tof ◽  
Tof Ms

Investigation of High-Risk ST131 Clone in Extended Spectrum β-Lactamase–Producing Escherichia coli Isolates in Children

2021 ◽  
Author(s):  
Mehmet E. Bulut ◽  
Gülen Hürkal ◽  
Nazan Dalgıç
Keyword(s):  
Escherichia Coli ◽  
High Risk ◽  
Pediatric Patients ◽  
Pediatric Population ◽  
Maldi Tof Ms ◽  
E Coli ◽  
Maldi Tof ◽  
Extended Spectrum ◽  
St131 Clone ◽  
Tof Ms

Abstract Objective Antimicrobial resistance poses a serious threat to children's health. In recent years, high-risk Escherichia coli ST131 has become an important target for global surveillance studies. The E.coli ST131 clone is associated with extended spectrum β-lactamase (ESBL) production, as well as multidrug resistance and treatment failure. Studies on this clone in the pediatric age group are limited. We aim to investigate the rate of high-risk E. coli ST131 clone in ESBL-positive E. coli isolates obtained from pediatric patients. Methods A total of 292 ESBL-positive E. coli isolates from clinical samples of pediatric patients was included in the study. MALDI-TOF MS system was used for bacterial identification. Susceptibility tests were performed using BD Phoenix automated system. ST131 detection was done by MALDI-TOF-MS. Fisher's exact test was used to compare the groups (significance <0.05). Results A total of 292 isolates was analyzed. The high-risk ST131 clone was detected in 117 (40%) of the 292 ESBL-positive isolates. ST131 rates were found to be significantly higher in children under the age of 5 years compared with children over the age of 5 years (49.3 vs. 31.1%, p = 0.0019). Ciprofloxacin resistance was higher in ST131 isolates (45.6 vs. 31.7%; p < 0.05). Conclusion The rate of the ST131 clone was found to be high in the pediatric population. The significantly high rate of resistance to ciprofloxacin, which is not commonly used in the pediatric population, in ST131 isolates reveals the importance of the spread of high-risk clones for the development of resistance.

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