Clonal Complexes and Antimicrobial Susceptibility Profiles ofStaphylococcus pseudintermediusIsolates from Dogs in the United States

2018 ◽  
Vol 24 (1) ◽  
pp. 83-88 ◽  
Author(s):  
Ricardo Videla ◽  
Samar M. Solyman ◽  
Akshar Brahmbhatt ◽  
Leslie Sadeghi ◽  
David A. Bemis ◽  
...  
Keyword(s):  
United States ◽  
Antimicrobial Susceptibility ◽  
The United States ◽  
Susceptibility Profiles

scholarly journals Antimicrobial Susceptibility to Azithromycin among Salmonella enterica Isolates from the United States

2011 ◽  
Vol 55 (9) ◽  
pp. 3985-3989 ◽  
Author(s):  
Maria Sjölund-Karlsson ◽  
Kevin Joyce ◽  
Karen Blickenstaff ◽  
Takiyah Ball ◽  
Jovita Haro ◽  
...  
Keyword(s):  
United States ◽  
Antimicrobial Susceptibility ◽  
Salmonella Enterica ◽  
Antimicrobial Agents ◽  
The United States ◽  
Outcome Data ◽  
Content Type ◽  
Susceptibility Data ◽  
Retail Meat ◽  
Clinical Breakpoints

ABSTRACTDue to emerging resistance to traditional antimicrobial agents, such as ampicillin, trimethoprim-sulfamethoxazole, and chloramphenicol, azithromycin is increasingly used for the treatment of invasiveSalmonellainfections. In the present study, 696 isolates of non-TyphiSalmonellacollected from humans, food animals, and retail meats in the United States were investigated for antimicrobial susceptibility to azithromycin. Seventy-twoSalmonella entericaserotype Typhi isolates from humans were also tested. For each isolate, MICs of azithromycin and 15 other antimicrobial agents were determined by broth microdilution. Among the non-TyphiSalmonellaisolates, azithromycin MICs among human isolates ranged from 1 to 32 μg/ml, whereas the MICs among the animal and retail meat isolates ranged from 2 to 16 μg/ml and 4 to 16 μg/ml, respectively. AmongSalmonellaserotype Typhi isolates, the azithromycin MICs ranged from 4 to 16 μg/ml. The highest MIC observed in the present study was 32 μg/ml, and it was detected in three human isolates belonging to serotypes Kentucky, Montevideo, and Paratyphi A. Based on our findings, we propose an epidemiological cutoff value (ECOFF) for wild-typeSalmonellaof ≤16 μg/ml of azithromycin. The susceptibility data provided could be used in combination with clinical outcome data to determine tentative clinical breakpoints for azithromycin andSalmonella enterica.

scholarly journals The antimicrobial susceptibility and virulence factors of Bacillus anthracis strains isolated in Croatia

2011 ◽  
Vol 56 (No. 1) ◽  
pp. 23-28 ◽  
Author(s):  
B. Habrun ◽  
I. Racic ◽  
G. Kompes ◽  
S. Spicic ◽  
M. Benic ◽  
...  
Keyword(s):  
United States ◽  
Bacillus Anthracis ◽  
Clavulanic Acid ◽  
Virulence Factors ◽  
Antimicrobial Susceptibility ◽  
The United States ◽  
Antimicrobial Substances

Bacillus anthracis can infect both livestock and humans. The importance of the treatment of the disease in humans has been underscored by the bioterrorism events of 2001 in the United States. The presence of PA and B/C genes (pX01 and pX02 plasmids) as well as susceptibility to several antimicrobial substances was determined in 11 strains of Bacillus anthracis isolated during two recent epizooties of anthrax which occurred in Croatia in 2002 among sheep and in 2006/2007 in cattle. The pX01 plasmid was observed in all of the examined strains, including vaccinal Sterne strains. However, the pX02 plasmid was detected in only eight out of eleven examined field strains of Bacillus anthracis while in vaccinal strains it was not detected at. Determination of MIC's revealed susceptibility to amoxicillin, amoxicillin with clavulanic acid, ciprofloxacin, gentamicin and tetracycline. All strains were resistant to sulfamethoxazole with trimethoprim and cefotaxime.

scholarly journals Antimicrobial Susceptibility Patterns of Brachyspira Species Isolated from Swine Herds in the United States

2016 ◽  
Vol 54 (8) ◽  
pp. 2109-2119 ◽  
Author(s):  
Nandita S. Mirajkar ◽  
Peter R. Davies ◽  
Connie J. Gebhart
Keyword(s):  
United States ◽  
Antimicrobial Susceptibility ◽  
North American ◽  
Bacterial Species ◽  
The United States ◽  
Swine Dysentery ◽  
Content Type ◽  
Brachyspira Pilosicoli ◽  
Swine Herds ◽  
And Control

Outbreaks of swine dysentery, caused byBrachyspira hyodysenteriaeand the recently discovered “Brachyspira hampsonii,” have reoccurred in North American swine herds since the late 2000s. Additionally, multipleBrachyspiraspecies have been increasingly isolated by North American diagnostic laboratories. In Europe, the reliance on antimicrobial therapy for control of swine dysentery has been followed by reports of antimicrobial resistance over time. The objectives of our study were to determine the antimicrobial susceptibility trends of fourBrachyspiraspecies originating from U.S. swine herds and to investigate their associations with the bacterial species, genotypes, and epidemiological origins of the isolates. We evaluated the susceptibility ofB. hyodysenteriae,B. hampsonii,Brachyspira pilosicoli, andBrachyspira murdochiito tiamulin, valnemulin, doxycycline, lincomycin, and tylosin by broth microdilution and that to carbadox by agar dilution. In general,Brachyspiraspecies showed high susceptibility to tiamulin, valnemulin, and carbadox, heterogeneous susceptibility to doxycycline, and low susceptibility to lincomycin and tylosin. A trend of decreasing antimicrobial susceptibility by species was observed (B. hampsonii>B. hyodysenteriae>B. murdochii>B. pilosicoli). In general,Brachyspiraisolates from the United States were more susceptible to these antimicrobials than were isolates from other countries. Decreased antimicrobial susceptibility was associated with the genotype, stage of production, and production system from which the isolate originated, which highlights the roles of biosecurity and husbandry in disease prevention and control. Finally, this study also highlights the urgent need for Clinical and Laboratory Standards Institute-approved clinical breakpoints forBrachyspiraspecies, to facilitate informed therapeutic and control strategies.

scholarly journals Antimicrobial Susceptibility and Clonality of Clinical Ureaplasma Isolates in the United States

2016 ◽  
Vol 60 (8) ◽  
pp. 4793-4798 ◽  
Author(s):  
Javier Fernández ◽  
Melissa J. Karau ◽  
Scott A. Cunningham ◽  
Kerryl E. Greenwood-Quaintance ◽  
Robin Patel
Keyword(s):  
United States ◽  
Antimicrobial Susceptibility ◽  
Antimicrobial Agents ◽  
Ureaplasma Urealyticum ◽  
Resistance Mechanism ◽  
The United States ◽  
Resistance Mechanisms ◽  
Resistant Isolate ◽  
Limited Information ◽  
Content Type

ABSTRACTUreaplasma urealyticumandUreaplasma parvumare pathogens involved in urogenital tract and intrauterine infections and also in systemic diseases in newborns and immunosuppressed patients. There is limited information on the antimicrobial susceptibility and clonality of these species. In this study, we report the susceptibility of 250 contemporary isolates ofUreaplasma(202U. parvumand 48U. urealyticumisolates) recovered at Mayo Clinic, Rochester, MN. MICs of doxycycline, azithromycin, ciprofloxacin, tetracycline, erythromycin, and levofloxacin were determined by broth microdilution, with MICS of the last three interpreted according to CLSI guidelines. Levofloxacin resistance was found in 6.4% and 5.2% ofU. parvumandU. urealyticumisolates, respectively, while 27.2% and 68.8% of isolates, respectively, showed ciprofloxacin MICs of ≥4 μg/ml. The resistance mechanism of levofloxacin-resistant isolates was due to mutations inparC, with the Ser83Leu substitution being most frequent, followed by Glu87Lys. No macrolide resistance was found among the 250 isolates studied; a singleU. parvumisolate was tetracycline resistant.tet(M) was found in 10U. parvumisolates, including the single tetracycline-resistant isolate, as well as in 9 isolates which had low tetracycline and doxycycline MICs. Multilocus sequence typing (MLST) performed on a selection of 46 isolates showed high diversity within the clinicalUreaplasmaisolates studied, regardless of antimicrobial susceptibility. The present work extends previous knowledge regarding susceptibility to antimicrobial agents, resistance mechanisms, and clonality ofUreaplasmaspecies in the United States.

scholarly journals Diversity of Bipolaris Species in Clinical Samples in the United States and Their Antifungal Susceptibility Profiles

2012 ◽  
Vol 50 (12) ◽  
pp. 4061-4066 ◽  
Author(s):  
K. C. da Cunha ◽  
D. A. Sutton ◽  
A. W. Fothergill ◽  
J. Cano ◽  
J. Gene ◽  
...  
Keyword(s):  
United States ◽  
Antifungal Susceptibility ◽  
The United States ◽  
Clinical Samples ◽  
Susceptibility Profiles
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