Analysis of Salmonella enterica with Reduced Susceptibility to the Third-Generation Cephalosporin Ceftriaxone Isolated from U.S. Cattle During 2000–2004

2008 ◽  
Vol 14 (4) ◽  
pp. 251-258 ◽  
Author(s):  
Jonathan G. Frye ◽  
Paula J. Fedorka-Cray ◽  
Charlene R. Jackson ◽  
Markus Rose
Keyword(s):  
Salmonella Enterica ◽  
Generation Cephalosporin ◽  
Third Generation ◽  
The Third

scholarly journals Extended-spectrum β-lactamase-producing Salmonella enterica serovar Oranienburg (CTX-M-2 group) in a pediatric hospital in Tucumán, Argentina

2010 ◽  
Vol 43 (2) ◽  
pp. 121-124 ◽  
Author(s):  
María Angela Jure ◽  
Olga Aulet ◽  
Ana Trejo ◽  
Marta Castillo
Keyword(s):  
Salmonella Enterica ◽  
Generation Cephalosporin ◽  
Third Generation ◽  
Pediatric Hospital ◽  
Extended Spectrum ◽  
Antibiotic Susceptibility Patterns ◽  
Resistant Strains ◽  
Multiresistant Strains ◽  
Extraintestinal Complications ◽  
Susceptibility Patterns

INTRODUCTION: Salmonella sp infections have been reported over recent years in hospitals in Argentina and other countries due to multiresistant strains. The aim of this study was to characterize the extended-spectrum β-lactamases in third-generation cephalosporin-resistant strains of Salmonella enterica serovar Oranienburg. METHODS: We studied 60 strains isolated from children with gastroenteritis and/or extraintestinal complications. The antibiotic susceptibility patterns of the isolates were analyzed and the β-lactamases were characterized using phenotyping and genotyping methods. RESULTS: All the strains were resistant to ampicillin, cefotaxime, cefepime and aztreonam and partially susceptible to ceftazidime, thus corresponding well with the resistance phenotype conferred by CTX-M-type β-lactamases. An isoelectric point enzyme (pI = 7.9) was detected in all of the strains, and this was confirmed by PCR as a member of the CTX-M-2 group. CONCLUSIONS: This is the first report of Salmonella enterica serovar Oranienburg producing β-lactamases of the CTX-M-2 group in a pediatric hospital in Tucumán, Argentina.

scholarly journals Comparative Activity of Several Antimicrobial Agents against Nosocomial Gram-Negative Rods Isolated across Canada

1995 ◽  
Vol 6 (2) ◽  
pp. 76-82 ◽  
Author(s):  
Shelley R Scriver ◽  
Canadian Antimicrobial Resistance Study Group ◽  
Donald E Low
Keyword(s):  
Antimicrobial Agents ◽  
Wide Spectrum ◽  
Generation Cephalosporin ◽  
Third Generation ◽  
Beta Lactamase ◽  
Gram Negative ◽  
The Third ◽  
Cephalosporin Resistance ◽  
Third Generation Cephalosporins ◽  
Group 1

In 1992, a surveillance study was performed in Canada to determine the susceptibility of nosocomial Gram-negative rods to several wide spectrum antimicrobials. Consecutive isolates from 10 institutions, as well as additional strains of selected species of Enterobacteriaceae that are known to possess the Bush group 1 beta-lactamase, were tested for susceptibility to 12 antimicrobials. Third-generation cephalosporin resistance was found to be as high as 29% inEnterobacter cloacaethat possesses the Bush group 1 beta-lactamase and less than 4% in those isolates not possessing this enzyme. Cefepime equalled or exceeded the activity of the third-generation cephalosporins against the species of Enterobacteriaceae that demonstrated resistance to the third-generation cephalosporins.

Clinical orientation of the third generation cephalosporin

2012 ◽  
Vol 12 (4) ◽  
pp. 241-248
Author(s):  
XianMin MENG ◽  
YinZhong SHEN ◽  
YongXin ZHANG
Keyword(s):  
Generation Cephalosporin ◽  
Third Generation ◽  
The Third ◽  
Clinical Orientation

scholarly journals First Clinical Case of In Vivo Acquisition of DHA-1 Plasmid-Mediated AmpC in a Salmonella enterica subsp. enterica Isolate

2019 ◽  
Vol 63 (10) ◽  
Author(s):  
Mathieu Clément ◽  
Peter M. Keller ◽  
Odette J. Bernasconi ◽  
Guido Stirnimann ◽  
Pascal M. Frey ◽  
...  
Keyword(s):  
Sri Lanka ◽  
Salmonella Enterica ◽  
Clinical Case ◽  
Generation Cephalosporin ◽  
Third Generation ◽  
Molecular Analyses ◽  
Content Type ◽  
First Report ◽  
Citrobacter Amalonaticus

ABSTRACT A pan-susceptible Salmonella enterica serovar Worthington isolate was detected in the stool of a man returning from Sri Lanka. Under ceftriaxone treatment, a third-generation cephalosporin (3GC)-resistant Salmonella Worthington was isolated after 8 days. Molecular analyses indicated that the two isolates were identical. However, the latter strain acquired a blaDHA-1-carrying IncFII plasmid probably from a Citrobacter amalonaticus isolate colonizing the gut. This is the first report of in vivo acquisition of plasmid-mediated resistance to 3GCs in S. enterica.

scholarly journals Synthesis, Characterization of Ceftibuten-Copper(II) Complex and Prediction of Its Biological Activity

2020 ◽  
Vol 33 (1) ◽  
pp. 190-194
Author(s):  
Shuchismita Dey ◽  
Md. Zakir Sultan ◽  
Md. Abdus Salam
Keyword(s):  
Antibacterial Activity ◽  
Generation Cephalosporin ◽  
Salmonella Typhi ◽  
In Vitro Test ◽  
Third Generation ◽  
The Third ◽  
Vitro Test ◽  
Cephalosporin Antibiotic

Ceftibuten dihydrate, one of the third-generation cephalosporin antibiotic is effectively used in curing several infectious diseases. The complexation of drug with metal may enhance the antibacterial activity. In this work, a new complex of ceftibuten dihydrate with Cu(II) was synthesized, characterized and antibacterial activity is reported. The in vitro test showed that the antibacterial activity of complex of ceftibuten was greatly enhanced against Staphylococcus aureus and Salmonella typhi.

scholarly journals The Study of Genetic Relationship Among Third Generation Cephalosporin-resistant Salmonella enterica Strains by ERIC-PCR

2013 ◽  
Vol 7 (1) ◽  
pp. 142-145 ◽  
Author(s):  
Reza Ranjbar ◽  
Ali Naghoni ◽  
Soheila Yousefi ◽  
Ali Ahmadi ◽  
Nematollah Jonaidi ◽  
...  
Keyword(s):  
Genetic Relationship ◽  
Salmonella Enterica ◽  
Pediatric Patients ◽  
Susceptibility Testing ◽  
Generation Cephalosporin ◽  
Third Generation ◽  
Extended Spectrum ◽  
Food Borne ◽  
Third Generation Cephalosporins ◽  
Salmonella Enterica Serotype Enteritidis

Background and Objectives:Salmonella is an important food-borne pathogen responsible for disease in humans and animals. The aim of this study was to investigate the genetic relationship among third generation cephalosporin-resistant Salmonella enterica strains by Enterobacterial Repetitive Intergenic Consensus (ERIC)-PCR.Methods:The study included all Salmonella isolates obtained from clinical cases in a pediatric hospital in Tehran, Iran during 2006 to 2009. Antimicrobial susceptibility testing was performed according to the Clinical and Laboratory Standards Institute. The genetic relationship between third generation cephalosporins-resistant Salmonella enterica strains was determined using ERIC-PCR.Results:Of 136 Salmonella enterica isolates recovered from pediatric patients, six isolates including four Salmonella enterica serotype Infantis and two Salmonella enterica serotype Enteritidis showed an extended-spectrum cephalosporins resistant phenotype. ERIC-PCR differentiated Salmonella enterica serotypes Infantis and Enteritidis into 2 distinct clusters arbitrarily named as E1 and E2. Profile E1 was found in two Salmonella enterica serotype Enteritidis isolates, and profile E2 was found in four Salmonella enterica serotype Infantis isolates.Conclusion:Extended-spectrum cephalosporins resistant Salmonella could be attributed to a few predominant serotypes including Enteritidis and Infantis in this study. Genetic analysis using ERIC-PCR showed that closely related clones are responsible for the occurrence of extended-spectrum cephalosporins resistant Salmonella infection in Tehran.

Resistance to the Third-Generation Cephalosporin Ceftazidime by a Deacylation-Deficient Mutant of the TEM β-Lactamase by the Uncommon Covalent-Trapping Mechanism

Biochemistry ◽  
2011 ◽  
Vol 50 (29) ◽  
pp. 6387-6395 ◽  
Author(s):  
Nuno T. Antunes ◽  
Hilary Frase ◽  
Marta Toth ◽  
Shahriar Mobashery ◽  
Sergei B. Vakulenko
Keyword(s):  
Generation Cephalosporin ◽  
Third Generation ◽  
Deficient Mutant ◽  
The Third ◽  
Trapping Mechanism ◽  
Covalent Trapping

scholarly journals THE THIRD-GENERATION CEPHALOSPORIN USE IN A REGIONAL GENERAL HOSPITAL IN INDONESIA

2018 ◽  
Vol 9 (9) ◽  
pp. 41-45 ◽  
Author(s):  
Rika Yulia ◽  
Beatrix Eyleen Giovanny ◽  
Azalia Ayla Khansa ◽  
Sylvia Putri Utami ◽  
Fawandi Fuad Alkindi ◽  
...  
Keyword(s):  
General Hospital ◽  
Generation Cephalosporin ◽  
Third Generation ◽  
The Third
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