Class 1 Integrons and Salmonella Genomic Island 1 Among Salmonella enterica Isolated from Poultry and Swine

2008 ◽  
Vol 14 (1) ◽  
pp. 65-70 ◽  
Author(s):  
Sirintip Khemtong ◽  
Rungtip Chuanchuen
Keyword(s):  
Salmonella Enterica ◽  
Genomic Island ◽  
Class 1 Integrons ◽  
Class 1

PREVALENCE OF CLASS 1 INTEGRONS IN CLINICAL ISOLATES OF NON-TYPHOIDAL $SALMONELLA~ENTERICA$ CIRCULATED IN ARMENIA

2021 ◽  
Vol 55 (1 (254)) ◽  
pp. 58-66
Author(s):  
Magdalina K. Zakharyan
Keyword(s):  
Multidrug Resistance ◽  
Antimicrobial Resistance ◽  
Clinical Significance ◽  
Antimicrobial Therapy ◽  
Salmonella Enterica ◽  
Clinical Isolates ◽  
Class 1 Integron ◽  
Class 1 Integrons ◽  
High Prevalence ◽  
Class 1

A total of 182 non-typhoid Salmonella enterica (NTS) isolates recovered from patients between 1996 and 2014 were included in the current study focused on class 1 integron detection and its association with multidrug resistance (MDR) phenotype. A high prevalence of isolates displaying MDR and penta-resistance (resistance to ampicillin, chloramphenicol, streptomycin, sulfonamide, tetracycline) phenotypes of clinical significance was revealed. Serotype-specific prevalence of antimicrobial resistance as well as class 1 integrons and inserted variable segments was detected in isolates. The results indicated the limitations of current antimicrobial therapy to control infections caused by MDR isolates of NTS, especially belonging to serotype Typhimurium.

scholarly journals Use of Inverse PCR for Analysis of Class 1 Integrons Carrying an Unusual 3′ Conserved Segment Structure

2010 ◽  
Vol 55 (2) ◽  
pp. 943-945 ◽  
Author(s):  
Mei-Feng Lee ◽  
Chien-Fang Peng ◽  
Hui-Jine Hsu ◽  
Han-Siong Toh
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Dna Sequencing ◽  
Salmonella Enterica ◽  
Southern Hybridization ◽  
Enterobacter Cloacae ◽  
Inverse Pcr ◽  
Chromosomal Dna ◽  
Pcr Assay ◽  
Class 1 Integrons ◽  
Class 1

ABSTRACTBy using inverse PCR and DNA sequencing, 13sul3-associated mutational integrons, 2 defective class 1 integrons, and 1qnrB2-associated complexsul1-type class 1 integrons were identified inSalmonella entericaserovar Choleraesuis,Pseudomonas aeruginosa, andEnterobacter cloacae, respectively. In addition, conjugation and Southern hybridization demonstrated that unusual class 1 integrons were located on plasmids or integrated into chromosomal DNA. Thus, an inverse PCR assay can be a valuable tool for the analysis of unusual structures of the 3′ conserved region of class 1 integrons.

scholarly journals New Integron-Associated Gene Cassette Encoding a Trimethoprim-Resistant DfrB-Type Dihydrofolate Reductase

2006 ◽  
Vol 50 (8) ◽  
pp. 2863-2865 ◽  
Author(s):  
Renee S. Levings ◽  
Diane Lightfoot ◽  
Liam D. H. Elbourne ◽  
Steven P. Djordjevic ◽  
Ruth M. Hall
Keyword(s):  
Dihydrofolate Reductase ◽  
Salmonella Enterica ◽  
Gene Cassette ◽  
Antibiotic Resistant ◽  
Class 1 Integrons ◽  
Class 1 ◽  
Type Gene

ABSTRACT A sixth gene cassette containing a dfrB-type gene, dfrB6, was found in a dfrB6-aadA1 cassette array in class 1 integrons. This array was isolated from several multiply antibiotic-resistant Salmonella enterica serovar Infantis strains that appear to be clonally related. The DfrB6 dihydrofolate reductase conferred resistance to trimethoprim.

Multiple-Antibiotic Resistance in Salmonella enterica Serovars Isolated in Iran Harboring Class 1 Integrons

2015 ◽  
Vol 5 (2) ◽  
pp. 186-193 ◽  
Author(s):  
Bahareh Rajaei ◽  
Nahid Rad ◽  
Farzad Badmasti ◽  
Mohamad Razavi ◽  
Mohammad Aghasadeghi ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Salmonella Enterica ◽  
Multiple Antibiotic Resistance ◽  
Class 1 Integrons ◽  
Class 1

scholarly journals Highly Drug-Resistant Salmonella enterica Serovar Indiana Clinical Isolates Recovered from Broilers and Poultry Workers with Diarrhea in China

2016 ◽  
Vol 60 (3) ◽  
pp. 1943-1947 ◽  
Author(s):  
Jiansen Gong ◽  
Chengming Wang ◽  
Shourong Shi ◽  
Hongduo Bao ◽  
Chunhong Zhu ◽  
...  
Keyword(s):  
Salmonella Enterica ◽  
Clinical Isolates ◽  
Drug Resistant ◽  
Content Type ◽  
Class 1 Integrons ◽  
Class 1 ◽  
Poultry Workers

Highly drug-resistantSalmonella entericaserovar Indiana became the most common serovar in broilers with diarrhea in China over the course of this study (15% in 2010 to 70% in 2014). While mostS. Indiana isolates (87%, 384/440) were resistant to 13 to 16 of the 16 antibiotics tested, 89% of non-S. Indiana isolates (528/595) were resistant to 0 to 6 antibiotics. Class 1 integrons and IncHI2-type plasmids were detected in allS. Indiana isolates, but only in 39% and 1% of non-S. Indiana isolates.

scholarly journals Truncated tni Module Adjacent to the Complex Integron of Salmonella Genomic Island 1 in Salmonella enterica Serovar Virchow

2008 ◽  
Vol 53 (2) ◽  
pp. 824-827 ◽  
Author(s):  
Benoît Doublet ◽  
Chishih Chu ◽  
Cheng-Hsun Chiu ◽  
Yi-Chin Fan ◽  
Axel Cloeckaert
Keyword(s):  
Multidrug Resistance ◽  
Salmonella Enterica ◽  
Genomic Island ◽  
Open Reading Frame ◽  
Complex Class ◽  
Class 1 Integron ◽  
Reading Frame ◽  
Class 1 ◽  
First Time

ABSTRACT Salmonella genomic island 1 was identified for the first time in Salmonella enterica serovar Virchow isolated from humans in Taiwan. The complex class 1 integron conferring multidrug resistance was shown to be inserted within open reading frame (ORF) S023 and contains for the first time a partial transpositional module. The 5-bp target duplication flanking the complex integron suggests that its insertion in ORF S023 was by transposition.

scholarly journals Tn6060, a Transposon from a Genomic Island in a Pseudomonas aeruginosa Clinical Isolate That Includes Two Class 1 Integrons

2009 ◽  
Vol 53 (12) ◽  
pp. 5294-5296 ◽  
Author(s):  
Piklu Roy Chowdhury ◽  
John Merlino ◽  
Maurizio Labbate ◽  
Elaine Y.-L. Cheong ◽  
Thomas Gottlieb ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Clinical Isolate ◽  
Genomic Island ◽  
Class 1 Integrons ◽  
Class 1

ABSTRACT A 25,441-bp transposon was recovered from a Pseudomonas aeruginosa clinical isolate. While the transposition module was >99% identical to sequence of Tn1403, the element had been subject to rearrangements, with two In70.2-like class 1 integrons inserted into it in an unusual “tail-to-tail” configuration. One cassette array was the same as that in In70.2; however, the second was different, generating a transposon that collectively includes six resistance cassettes.

scholarly journals SGI1-K, a Variant of the SGI1 Genomic Island Carrying a Mercury Resistance Region, in Salmonella enterica Serovar Kentucky

2006 ◽  
Vol 51 (1) ◽  
pp. 317-323 ◽  
Author(s):  
Renee S. Levings ◽  
Sally R. Partridge ◽  
Steven P. Djordjevic ◽  
Ruth M. Hall
Keyword(s):  
Salmonella Enterica ◽  
Genomic Island ◽  
Mercury Resistance ◽  
Variant Form ◽  
Short Segment ◽  
Class 1 Integron ◽  
Antibiotic Resistant ◽  
Right Hand ◽  
Class 1 ◽  
The Right

ABSTRACT A multiple-antibiotic-resistant Salmonella enterica serovar Kentucky strain was found to contain SGI1-K, a variant form of the Salmonella genomic island 1 (SGI1) with an In4-type class 1 integron that contains only one cassette array, aacCA5-aadA7, and an adjacent mercury resistance module. Part of the 3′-conserved segment (3′-CS) of the integron, together with the inverted short segment from the right-hand end of the integron transposition module normally found between the 3′-CS and IS6100 in In4 family integrons, has been removed by an IS6100-mediated deletion. IRt, the right-hand inverted repeat found at the outer end of the integron, abuts a mercury resistance region instead of the usual SGI1 backbone segment. The mer module is a hybrid of those found in Tn501 and Tn21. This mer region and a further uncharacterized segment of at least 10 kb appear to have been incorporated between IRt and the SGI1 backbone. These findings demonstrate that the multidrug resistance region in SGI1 can incorporate new DNA segments in the same way as multiple antibiotic resistance regions in plasmids.

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