scholarly journals Aged Lymphatic Contractility: Recent Answers and New Questions

2013 ◽  
Vol 11 (1) ◽  
pp. 2-13 ◽  
Author(s):  
Anatoliy A. Gashev ◽  
Victor Chatterjee
Keyword(s):  
Lymphatic Contractility

The effect of anesthetics on lymphatic contractility

1989 ◽  
Vol 37 (1) ◽  
pp. 70-76 ◽  
Author(s):  
N.G. McHale ◽  
K.D. Thornbury
Keyword(s):  
Lymphatic Contractility

CULTURE OF LYMPHATIC VESSELS AND DEVELOPMENT OF TRANSFECTION TECHNIQUES TO TARGET GENES INVOLVED IN REGULATION OF LYMPHATIC CONTRACTILITY

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Anatoliy A. Gashev ◽  
Patrick Dougherty ◽  
Olga Yu. Gasheva ◽  
Zhanna V. Nepiushchikh ◽  
Wei Wang ◽  
...  
Keyword(s):  
Target Genes ◽  
Lymphatic Vessels ◽  
Lymphatic Contractility

Lymphatic Contractility and Oxidative Stress

2014 ◽  
pp. 2069-2082 ◽  
Author(s):  
Anatoliy A. Gashev ◽  
Sangeetha Thangaswamy ◽  
Victor Chatterjee
Keyword(s):  
Oxidative Stress ◽  
And Oxidative Stress ◽  
Lymphatic Contractility

scholarly journals cGMP/PKG‐mediated regulation of lymphatic contractility

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Olga Yu. Gasheva ◽  
Anatoliy A. Gashev ◽  
David C. Zawieja
Keyword(s):  
Lymphatic Contractility

Regulation of lymphatic contractility by arachidonate metabolites

Nature ◽  
1981 ◽  
Vol 293 (5830) ◽  
pp. 294-297 ◽  
Author(s):  
M. G. Johnston ◽  
J. L. Gordon
Keyword(s):  
Arachidonate Metabolites ◽  
Lymphatic Contractility

scholarly journals Characterization of rat tail lymphatic contractility and biomechanics: incorporating nitric oxide-mediated vasoregulation

2020 ◽  
Vol 17 (170) ◽  
pp. 20200598 ◽  
Author(s):  
Mohammad S. Razavi ◽  
J. Brandon Dixon ◽  
Rudolph L. Gleason
Keyword(s):  
Nitric Oxide ◽  
Mechanical Response ◽  
Contractile Function ◽  
Ex Vivo ◽  
Biomechanical Model ◽  
Biomechanical Models ◽  
Lymphatic Pumping ◽  
Rat Tail ◽  
Lymphatic Contractility

The lymphatic system transports lymph from the interstitial space back to the great veins via a series of orchestrated contractions of chains of lymphangions. Biomechanical models of lymph transport, validated with ex vivo or in vivo experimental results, have proved useful in revealing novel insight into lymphatic pumping; however, a need remains to characterize the contributions of vasoregulatory compounds in these modelling tools. Nitric oxide (NO) is a key mediator of lymphatic pumping. We quantified the active contractile and passive biaxial biomechanical response of rat tail collecting lymphatics and changes in the contractile response to the exogenous NO administration and integrated these findings into a biomechanical model. The passive mechanical response was characterized with a three-fibre family model. Nonlinear regression and non-parametric bootstrapping were used to identify best-fit material parameters to passive cylindrical biaxial mechanical data, assessing uniqueness and parameter confidence intervals; this model yielded a good fit ( R 2 = 0.90). Exogenous delivery of NO via sodium nitroprusside (SNP) elicited a dose-dependent suppression of contractions; the amplitude of contractions decreased by 30% and the contraction frequency decreased by 70%. Contractile function was characterized with a modified Rachev–Hayashi model, introducing a parameter that is related to SNP concentration; the model provided a good fit ( R 2 = 0.89) to changes in contractile responses to varying concentrations of SNP. These results demonstrated the significant role of NO in lymphatic pumping and provide a predictive biomechanical model to integrate the combined effect of mechanical loading and NO on lymphatic contractility and mechanical response.

scholarly journals Spatio-Temporal Changes of Lymphatic Contractility and Drainage Patterns following Lymphadenectomy in Mice

PLoS ONE ◽  
2014 ◽  
Vol 9 (8) ◽  
pp. e106034 ◽  
Author(s):  
Sunkuk Kwon ◽  
Germaine D. Agollah ◽  
Grace Wu ◽  
Eva M. Sevick-Muraca
Keyword(s):  
Temporal Changes ◽  
Drainage Patterns ◽  
Spatio Temporal ◽  
Lymphatic Contractility

A Novel Approach to Quantifying Lymphatic Contractility during Indocyanine Green Lymphangiography

2019 ◽  
Vol 144 (5) ◽  
pp. 1197-1201 ◽  
Author(s):  
Melisa D. Granoff ◽  
Anna Rose Johnson ◽  
Bernard T. Lee ◽  
Timothy P. Padera ◽  
Echoe M. Bouta ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Novel Approach ◽  
Lymphatic Contractility

scholarly journals LYMPHATIC CONTRACTILITY

1949 ◽  
Vol 90 (5) ◽  
pp. 497-509 ◽  
Author(s):  
Ralph O. Smith
Keyword(s):  
Guinea Pigs ◽  
Electric Stimulation ◽  
Lymphatic Vessels ◽  
Essential Elements ◽  
Intradermal Injection ◽  
Intraluminal Pressure ◽  
Intrinsic Mechanism ◽  
Sciatic Nerves ◽  
Stimulation Of ◽  
Lymphatic Contractility

The most peripheral lymphatic vessels of rats, mice, and guinea pigs were found to possess a spontaneous intermittent contractility. (a) The rate of contraction was shown to be directly proportional to the rate of formation of lymph and contractions were apparently initiated by an increase in intraluminal pressure. (b) Epinephrine and pituitrin caused an increased contractile rate, or lymphatic spasm, whereas novocaine caused cessation of movement and lymphatic dilatation. (c) Section or electric stimulation of femoral and sciatic nerves did not alter the contractile rate of popliteal lymphatics. This spontaneous lymphatic contractility was not observed in rabbits and dogs although the lymphatic vessels did contract when irritated. Epinephrine, pituitrin, and novocaine produced the same effects as observed in the smaller mammals. Dilatation of lymphatic vessels produced by intradermal injection of fluid, massage, or passive motion was followed by a rapid return of the vessel to normal caliber. The frequency of valves in lymphatic vessels, the distensibility of the lymphatics, and their ability to return to normal caliber against an increased gradient of pressure are considered to be the essential elements of an intrinsic mechanism contributing to the transport of lymph.

scholarly journals Effects of C‐reactive protein on rat mesenteric lymphatic contractility

2006 ◽  
Vol 20 (5) ◽  
Author(s):  
Zhanna V. Nepiyushchikh ◽  
Anatoliy A. Gashev ◽  
David C. Zawieja ◽  
Rita M. Heuertz ◽  
Uthayashanker Ezekiel ◽  
...  
Keyword(s):  
C Reactive Protein ◽  
Reactive Protein ◽  
Lymphatic Contractility
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